HIV infection is associated with the premature onset of age-associated co-morbidities such as non-AIDS malignancies and cardiovascular disease. These co-morbidities have been linked to persistently elevated serum levels of proinflammatory cytokines that mimic an aging phenotype known as

Public Health Relevance

HIV infection is associated with chronic inflammation which can lead to the premature onset of immune aging in middle aged persons. Immune aging can lead to the development of chronic conditions, such as heart disease and cancer. Treatments that reduce inflammation have the potential to reverse immune aging. We propose to test fish oil, a known anti-inflammatory, to reverse immune aging in HIV+ persons.

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Exploratory Grants (P20)
Project #
1P20MD006886-01
Application #
8356067
Study Section
Special Emphasis Panel (ZMD1-RN (01))
Project Start
2012-05-25
Project End
2017-01-31
Budget Start
2012-05-25
Budget End
2013-01-31
Support Year
1
Fiscal Year
2012
Total Cost
$181,021
Indirect Cost
$51,638
Name
Rush University Medical Center
Department
Type
DUNS #
068610245
City
Chicago
State
IL
Country
United States
Zip Code
60612
Turner, Arlener D; Capuano, Ana W; Wilson, Robert S et al. (2015) Depressive symptoms and cognitive decline in older african americans: two scales and their factors. Am J Geriatr Psychiatry 23:568-78
Barnes, Lisa L; Bennett, David A (2014) Alzheimer's disease in African Americans: risk factors and challenges for the future. Health Aff (Millwood) 33:580-6
Rajan, Kumar B; Wilson, Robert S; Skarupski, Kimberly A et al. (2014) Gene-behavior interaction of depressive symptoms and the apolipoprotein E {varepsilon}4 allele on cognitive decline. Psychosom Med 76:101-8
Fleischman, Debra A; Leurgans, Sue; Arfanakis, Konstantinos et al. (2014) Gray-matter macrostructure in cognitively healthy older persons: associations with age and cognition. Brain Struct Funct 219:2029-49
Tangney, Christy C; Li, Hong; Wang, Yamin et al. (2014) Relation of DASH- and Mediterranean-like dietary patterns to cognitive decline in older persons. Neurology 83:1410-6
James, Bryan D; Leurgans, Sue E; Hebert, Liesi E et al. (2014) Contribution of Alzheimer disease to mortality in the United States. Neurology 82:1045-50
Arfanakis, Konstantinos; Fleischman, Debra A; Grisot, Giorgia et al. (2013) Systemic inflammation in non-demented elderly human subjects: brain microstructure and cognition. PLoS One 8:e73107