The P20 award by the NCMHD to LLU in 2005 was instrumental for establishing the first and only COE on health disparities research in the Inland Empire of Southern California. The mission of this center is to reduce or eliminate health disparities in the local communities and nationally through a robust biomedical Research Core focused on diabetes and cancer that is interconnected with a comprehensive Research Training and Education Core, and a dynamic and successful Community Outreach and Engagement Core. The CHDMM serves a vast geographical area with a population of over 3.5 million. It is estimated that by 2015, over 55% of the population in this region will belong to ethnic groups (i.e. Hispanics and African American) that traditionally have a low socioeconomic status and disadvantaged background (LSESDB). The California County Health Status Profiles 2011 ranked this region poorly in health, and in age related deaths due to diabetes and cancer (2). The CHDMM is now poised for continuing expanding its sustainability and growth. The Center is currently comprised of 14 principal investigators with faculty appointments at the LLU Schools of Medicine and Public Health. Seven of these investigators are physically housed in contiguous laboratories within the CHDMM, focusing their research programs on biological and translational aspects of diabetes and cancer. In addition, a number of faculty members in the basic science departments ofthe School of Medicine hold adjunct member appointments in the CHDMM and contribute with their expertise in areas that complement the research mission of this center. A weekly "chalk talk style" informal research seminar brings together these investigators and provides a forum where original, unpublished data are discussed. CHDMM researchers interact on a regular basis to address biological aspects underlying health disparities, design translational initiatives, and create and expand programs for community education and participation. The LLU CHDMM Annual Health Disparities Symposium also showcases research progress and brings together the biomedical research community, research trainees, university administrators, community leaders, and national leaders in health disparities. These interactions create a highly dynamic and collegial environment for collaborative research, training the next generation of health disparities researchers, and focusing community engagement.

National Institute of Health (NIH)
National Institute on Minority Health and Health Disparities (NIMHD)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZMD1-RN)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Loma Linda University
Loma Linda
United States
Zip Code
Liu, Jo-Wen; Montero, Manuel; Bu, Liming et al. (2015) Epidermal fatty acid-binding protein protects nerve growth factor-differentiated PC12 cells from lipotoxic injury. J Neurochem 132:85-98
Spencer-Hwang, Rhonda; Montgomery, Susanne; Dougherty, Molly et al. (2014) Experiences of a rail yard community: life is hard. J Environ Health 77:8-17
Payne, Kimberly J; Dovat, Sinisa (2014) G0S2--a new player in leukemia. Leuk Res 38:147-8
Salto, Lorena M; Riggs, Matt L; Delgado De Leon, Daisy et al. (2014) Underrepresented minority high school and college students report STEM-pipeline sustaining gains after participating in the Loma Linda University Summer Health Disparities Research Program. PLoS One 9:e108497
Weldon, David J; Saulsbury, Marilyn D; Goh, Joshua et al. (2014) One-pot synthesis of cinnamylideneacetophenones and their in vitro cytotoxicity in breast cancer cells. Bioorg Med Chem Lett 24:3381-4
Pacheco, Fabio J; Almaguel, Frankis G; Evans, Whitney et al. (2014) Docosahexanoic acid antagonizes TNF-?-induced necroptosis by attenuating oxidative stress, ceramide production, lysosomal dysfunction, and autophagic features. Inflamm Res 63:859-71
Salud, Margaret C; Marshak, Helen Hopp; Natto, Zuhair S et al. (2014) Exploring HIV-testing intentions in young Asian/Pacific Islander (API) women as it relates to acculturation, theory of gender and power (TGP), and the AIDS risk reduction model (ARRM). AIDS Care 26:642-7
Galloway, Nicholas R; Diaz Osterman, Carlos J; Reiber, Karl et al. (2014) Yin Yang 1 regulates the transcriptional repression of Survivin. Biochem Biophys Res Commun 445:208-13
Figueroa, Johnny D; De Leon, Marino (2014) Neurorestorative targets of dietary long-chain omega-3 fatty acids in neurological injury. Mol Neurobiol 50:197-213
Dai, Liping; Li, Jitian; Ortega, Rosalia et al. (2014) Preferential autoimmune response in prostate cancer to cyclin B1 in a panel of tumor-associated antigens. J Immunol Res 2014:827827

Showing the most recent 10 out of 14 publications