Federal agencies mandate the inclusion of minority groups in study populations, yet researchers face many obstacles in reaching these underserved groups, including mistrust about the scientific community and poor past experiences. This holds true for minorities in the Southern California Inland Empire Region (IE) and San Bernardino County (SBC), where Hispanic and Black/African American communities comprise nearly 60 percent (48.1 and 9.5 percent, respectively) of the population. The IE has been identified as the most sprawling region in the U S, with a lack of transportation choices, town centers, and mixed use neighborhoods, and poorly connected street networks '^^'^""""""""l There is a dearth of open spaces: one third of children 0-18 do not live within walking distance of a park, playground, or open area. Moreover, it is considered one of the unhealthiest regions of California, with only 1 of every 6 stores/restaurants selling healthy food. Race/ethnicity related health disparities are especially seen for breast cancer, prostate cancer, overweight and obesity and diabetes. For instance, breast cancer incidence in Black women compared to non-Hispanic White women is higher (124.1 cases/100,000 vs. 116.6 cases/100000, respectively), and, even more importantly. Black women suffer from higher breast cancer mortality rates than non-Hispanic Whites due to more aggressive forms of the disease. SBC has higher prostate cancer incidence in Black versus White men (135.1 cases/100,000 vs. 243 cases/100,000, respectively), and Black men have mortality rates nearly 2.5 to 6 times that of other male groups from prostate cancer. Additionally, diabetes diagnosis is higher in Latinos and Blacks vs. Whites'^^'as are complications and worse outcomes''. Among adults, 63% are overweight or obese, and diabetes-related deaths are 120.9 per 100,000. Many areas fit the definition of high need. Medically Underserved Areas (MUAs). Despite these well documented disparities, the IE receives less per capita funding from grant-makers and foundations compared to the statewide average ($3 versus $119, respectively) and substantially less federal funding per capita ($21 vs. $1,507 nationally).

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Exploratory Grants (P20)
Project #
5P20MD006988-02
Application #
8485673
Study Section
Special Emphasis Panel (ZMD1-RN)
Project Start
Project End
Budget Start
2013-02-01
Budget End
2014-01-31
Support Year
2
Fiscal Year
2013
Total Cost
$86,894
Indirect Cost
$26,405
Name
Loma Linda University
Department
Type
DUNS #
009656273
City
Loma Linda
State
CA
Country
United States
Zip Code
92350
Francis, Olivia L; Milford, Terry-Ann M; Martinez, Shannalee R et al. (2016) A novel xenograft model to study the role of TSLP-induced CRLF2 signals in normal and malignant human B lymphopoiesis. Haematologica 101:417-26
Basu, Anamika; Cajigas-Du Ross, Christina K; Rios-Colon, Leslimar et al. (2016) LEDGF/p75 Overexpression Attenuates Oxidative Stress-Induced Necrosis and Upregulates the Oxidoreductase ERP57/PDIA3/GRP58 in Prostate Cancer. PLoS One 11:e0146549
Spencer-Hwang, Rhonda; Soret, Sam; Ghamsary, Mark et al. (2016) Gender Differences in Respiratory Health of School Children Exposed to Rail Yard-Generated Air Pollution: The ENRRICH Study. J Environ Health 78:8-16
Milford, Terry-Ann M; Su, Ruijun J; Francis, Olivia L et al. (2016) TSLP or IL-7 provide an IL-7Rα signal that is critical for human B lymphopoiesis. Eur J Immunol 46:2155-61
Brantley, Eileen; Callero, Mariana A; Berardi, Damian E et al. (2016) AhR ligand Aminoflavone inhibits α6-integrin expression and breast cancer sphere-initiating capacity. Cancer Lett 376:53-61
Wang, Haijun; Song, Chunhua; Ding, Yali et al. (2016) Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia. J Biol Chem 291:4004-18
Díaz Osterman, Carlos J; Gonda, Amber; Stiff, TessaRae et al. (2016) Curcumin Induces Pancreatic Adenocarcinoma Cell Death Via Reduction of the Inhibitors of Apoptosis. Pancreas 45:101-9
Sanchez, Tino W; Zhang, Guangyu; Li, Jitian et al. (2016) Immunoseroproteomic Profiling in African American Men with Prostate Cancer: Evidence for an Autoantibody Response to Glycolysis and Plasminogen-Associated Proteins. Mol Cell Proteomics 15:3564-3580
Turay, David; Khan, Salma; Diaz Osterman, Carlos J et al. (2016) Proteomic Profiling of Serum-Derived Exosomes from Ethnically Diverse Prostate Cancer Patients. Cancer Invest 34:1-11
Salto, Lorena M; Bu, Liming; Beeson, W Lawrence et al. (2016) The Ala54Thr Polymorphism of the Fatty Acid Binding Protein 2 Gene Modulates HDL Cholesterol in Mexican-Americans with Type 2 Diabetes. Int J Environ Res Public Health 13:ijerph13010052

Showing the most recent 10 out of 79 publications