Federal agencies mandate the inclusion of minority groups in study populations, yet researchers face many obstacles in reaching these underserved groups, including mistrust about the scientific community and poor past experiences. This holds true for minorities in the Southern California Inland Empire Region (IE) and San Bernardino County (SBC), where Hispanic and Black/African American communities comprise nearly 60 percent (48.1 and 9.5 percent, respectively) of the population. The IE has been identified as the most sprawling region in the U S, with a lack of transportation choices, town centers, and mixed use neighborhoods, and poorly connected street networks '^^'^""""""""l There is a dearth of open spaces: one third of children 0-18 do not live within walking distance of a park, playground, or open area. Moreover, it is considered one of the unhealthiest regions of California, with only 1 of every 6 stores/restaurants selling healthy food. Race/ethnicity related health disparities are especially seen for breast cancer, prostate cancer, overweight and obesity and diabetes. For instance, breast cancer incidence in Black women compared to non-Hispanic White women is higher (124.1 cases/100,000 vs. 116.6 cases/100000, respectively), and, even more importantly. Black women suffer from higher breast cancer mortality rates than non-Hispanic Whites due to more aggressive forms of the disease. SBC has higher prostate cancer incidence in Black versus White men (135.1 cases/100,000 vs. 243 cases/100,000, respectively), and Black men have mortality rates nearly 2.5 to 6 times that of other male groups from prostate cancer. Additionally, diabetes diagnosis is higher in Latinos and Blacks vs. Whites'^^'as are complications and worse outcomes''. Among adults, 63% are overweight or obese, and diabetes-related deaths are 120.9 per 100,000. Many areas fit the definition of high need. Medically Underserved Areas (MUAs). Despite these well documented disparities, the IE receives less per capita funding from grant-makers and foundations compared to the statewide average ($3 versus $119, respectively) and substantially less federal funding per capita ($21 vs. $1,507 nationally).

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Exploratory Grants (P20)
Project #
5P20MD006988-02
Application #
8485673
Study Section
Special Emphasis Panel (ZMD1-RN)
Project Start
Project End
Budget Start
2013-02-01
Budget End
2014-01-31
Support Year
2
Fiscal Year
2013
Total Cost
$86,894
Indirect Cost
$26,405
Name
Loma Linda University
Department
Type
DUNS #
009656273
City
Loma Linda
State
CA
Country
United States
Zip Code
92350
Lewis, Charlotte M; Gamboa-Maldonado, Thelma; Carlos Belliard, Juan et al. (2018) Patient and Community Health Worker Perceptions of Community Health Worker Clinical Integration. J Community Health :
Descorbeth, Magda; Figueroa, Karen; Serrano-Illán, Miguel et al. (2018) Protective effect of docosahexaenoic acid on lipotoxicity-mediated cell death in Schwann cells: Implication of PI3K/AKT and mTORC2 pathways. Brain Behav 8:e01123
Arthur, Kristen N; Spencer-Hwang, Rhonda; Knutsen, Synnøve F et al. (2018) Are perceptions of community safety associated with respiratory illness among a low-income, minority adult population? BMC Public Health 18:1089
Cajigas-Du Ross, Christina K; Martinez, Shannalee R; Woods-Burnham, Leanne et al. (2018) RNA sequencing reveals upregulation of a transcriptomic program associated with stemness in metastatic prostate cancer cells selected for taxane resistance. Oncotarget 9:30363-30384
Rowland, Leah K; Campbell, Petreena S; Mavingire, Nicole et al. (2018) Putative tumor suppressor cytoglobin promotes aryl hydrocarbon receptor ligand-mediated triple negative breast cancer cell death. J Cell Biochem :
Woods-Burnham, Leanne; Cajigas-Du Ross, Christina K; Love, Arthur et al. (2018) Glucocorticoids Induce Stress Oncoproteins Associated with Therapy-Resistance in African American and European American Prostate Cancer Cells. Sci Rep 8:15063
Woods-Burnham, Leanne; Stiel, Laura; Wilson, Colwick et al. (2018) Physician Consultations, Prostate Cancer Knowledge, and PSA Screening of African American Men in the Era of Shared Decision-Making. Am J Mens Health 12:751-759
Campbell, Petreena S; Mavingire, Nicole; Khan, Salma et al. (2018) AhR ligand aminoflavone suppresses ?6-integrin-Src-Akt signaling to attenuate tamoxifen resistance in breast cancer cells. J Cell Physiol 234:108-121
Cordero, Kathia; Coronel, Gemma G; Serrano-Illán, Miguel et al. (2018) Effects of Dietary Vitamin E Supplementation in Bladder Function and Spasticity during Spinal Cord Injury. Brain Sci 8:
Greer-Phillips, Suzanne E; Sukomon, Nattakan; Chua, Teck Khiang et al. (2018) THE AER2 RECEPTOR FROM VIBRIO CHOLERAE IS A DUAL PAS-HEME OXYGEN SENSOR. Mol Microbiol :

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