This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Accounting for evolutionary change in infectious agents represents a key challenge for medicine in the 21st century. Examples of rapid evolution of pathogens affecting human health abound. Particularly relevant is the evolution of antibiotic resistance leading to """"""""superbugs"""""""" in diverse pathogens, including bacteria, fungi, and viruses, and the evolution associated with the invasion of a pathgen onto a new host. Here, two new projects for the University of Idaho COBRE grant are proposed aimed at facilitating the transition into biomedically-relevant research by two outstanding young investigators by supporting them at a level that will accelerate their transition to independent funding. The first project will study the evolution of antibiotic resistance in bacterial biofilms, well-known for their resistance to antibiotic treatment, with two specific aims: (1) to compare the extent of evolved antibiotic resistance in bacteria grown in biofilms versus batch culture, and (2) to assess the generality of these findings by extending the study to other species and growth conditions.
These aims will be addressed by growing bacterial biofilms in the lab and measuring how their phenotypes change through time. The second project develops a model system for studies of emerging fungal pathogens in vertebrates. It focuses on gaining a mechanistic understading of the evolution of a recently discovered fungal pathogen, the chytrid Batrachochytrium dendrobatidis (Bd), responsible for amphibian population declines around the world. there are two specific aims: (1) to evaluate the genomic changes associated with the transition to pathogenicity and (2) to evaluate the genetic signatures associated with hyper-virulence.
These aims will be achieved by sequencing whole genomes of non-Bd chytrids and Bd strains that differ in virulence, then using comparative and functional genomics approaches to identify candidate pathogenicity/virulence genes. This supplement will accelerate the development of biomedical research programs at the University of Idaho by providing these faculty with sufficient resources to rapidly acquire proof-of-principle data to support full-scale, independent proposals.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Exploratory Grants (P20)
Project #
Application #
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Idaho
Schools of Arts and Sciences
United States
Zip Code
Stockmann, Chris; Ampofo, Krow; Pavia, Andrew T et al. (2016) Clinical and Epidemiological Evidence of the Red Queen Hypothesis in Pneumococcal Serotype Dynamics. Clin Infect Dis 63:619-26
Yano, Hirokazu; Wegrzyn, Katarznya; Loftie-Eaton, Wesley et al. (2016) Evolved plasmid-host interactions reduce plasmid interference cost. Mol Microbiol 101:743-56
Loftie-Eaton, Wesley; Yano, Hirokazu; Burleigh, Stephen et al. (2016) Evolutionary Paths That Expand Plasmid Host-Range: Implications for Spread of Antibiotic Resistance. Mol Biol Evol 33:885-97
Chernikova, Diana A; Koestler, Devin C; Hoen, Anne Gatewood et al. (2016) Fetal exposures and perinatal influences on the stool microbiota of premature infants. J Matern Fetal Neonatal Med 29:99-105
Uribe-Convers, Simon; Settles, Matthew L; Tank, David C (2016) A Phylogenomic Approach Based on PCR Target Enrichment and High Throughput Sequencing: Resolving the Diversity within the South American Species of Bartsia L. (Orobanchaceae). PLoS One 11:e0148203
Garud, Nandita R; Messer, Philipp W; Buzbas, Erkan O et al. (2015) Recent selective sweeps in North American Drosophila melanogaster show signatures of soft sweeps. PLoS Genet 11:e1005004
Uribe-Convers, Simon; Tank, David C (2015) Shifts in diversification rates linked to biogeographic movement into new areas: An example of a recent radiation in the Andes. Am J Bot 102:1854-69
Tank, David C; Eastman, Jonathan M; Pennell, Matthew W et al. (2015) Nested radiations and the pulse of angiosperm diversification: increased diversification rates often follow whole genome duplications. New Phytol 207:454-67
Loftie-Eaton, Wesley; Suzuki, Haruo; Bashford, Kelsie et al. (2015) Draft Genome Sequence of Pseudomonas sp. nov. H2. Genome Announc 3:
MacPherson, Ailene; Hohenlohe, Paul A; Nuismer, Scott L (2015) Trait dimensionality explains widespread variation in local adaptation. Proc Biol Sci 282:

Showing the most recent 10 out of 189 publications