In this application, we propose to provide a multidisciplinary platform for mentoring women in science and engineering (WISE) to have sucessful careers in osteoarthritis research. This builds on the work of our first Center of Biomedical Research Excellence (COBRE) award on osteoarthritis (OA). Each project in this application is led by a women faculty member and all junior faculty will have scientific mentors and career mentors to help them in the transition to becoming tenured faculty with NIH support. In our three-pronged approach, we will extablish external networks, internal mentoring, and university-wide programs to increase institutional awareness of gender issues. This COBRE award operates through our Center for BiomedicalEngineering Research (CBER) at the University of Delaware.
The aim of the Center is to create theinfrastructure and expertise base to address the mechanisms of OA, as well as its prevention and treatment.The uniqueness of the approach to be employed by our center will be the examination of OA from theintegrated, multidisciplinary translational perspectives of biochemistry, tissue mechanics, biomechanics,physical therapy and clinical intervention. Some of the core scientific areas of expertise in the proposedprogram are well-established at the University of Delaware, but they have traditionally been spread acrossdifferent laboratories in different departments and have minimal involvement of junior faculty members. In the context of our proposed work, we will build upon the distinctive organization of CBER established with the COBRE award and the collaborative projects described in this application. Five subprojects will be carried out under the Center umbrella. The subprojects are multidisciplinary and the participants are drawn from multiple academic units in the Colleges of Engineering, Arts &Sciences, and Health Sciences. The projecttitles are (1) Perlecan and Heparanase in Cartilage Growth and Healing, (2) Solute Transport in theSubchondral Bone Plate of Osteoarthritic Joints, (3) Risk Factors for Progression of Osteoarthritis of the Knee, (4) Joint Loading and the Progression of Osteoarthritis following Total Knee Arthroplasty (TKA), and (5) Knee Stiffness, Proprioception and Instability affect Knee Control in OA.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Exploratory Grants (P20)
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Special Emphasis Panel (ZRR1-RI-5 (01))
Program Officer
Douthard, Regine
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University of Delaware
Biomedical Engineering
Schools of Engineering
United States
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Rehmann, Matthew S; Luna, Jesus I; Maverakis, Emanual et al. (2016) Tuning microenvironment modulus and biochemical composition promotes human mesenchymal stem cell tenogenic differentiation. J Biomed Mater Res A 104:1162-74
Pozzi, Federico; Marmon, Adam R; Snyder-Mackler, Lynn et al. (2016) Lower leg compensatory strategies during performance of a step up and over task in patient six-months after total knee arthroplasty. Gait Posture 49:41-46
Moore, A C; DeLucca, J F; Elliott, D M et al. (2016) Quantifying Cartilage Contact Modulus, Tension Modulus, and Permeability With Hertzian Biphasic Creep. J Tribol 138:0414051-414057
Abujaber, Sumayeh; Gillispie, Gregory; Marmon, Adam et al. (2015) Validity of the Nintendo Wii Balance Board to assess weight bearing asymmetry during sit-to-stand and return-to-sit task. Gait Posture 41:676-82
Zimmerman, B K; Bonnevie, E D; Park, M et al. (2015) Role of interstitial fluid pressurization in TMJ lubrication. J Dent Res 94:85-92
Moore, A C; Zimmerman, B K; Chen, X et al. (2015) Experimental characterization of biphasic materials using rate-controlled Hertzian indentation. Tribol Int 89:2-8
Moore, A C; Burris, D L (2015) Tribological and material properties for cartilage of and throughout the bovine stifle: support for the altered joint kinematics hypothesis of osteoarthritis. Osteoarthritis Cartilage 23:161-9
Pozzi, Federico; Snyder-Mackler, Lynn; Zeni Jr, Joseph (2015) Relationship between biomechanical asymmetries during a step up and over task and stair climbing after total knee arthroplasty. Clin Biomech (Bristol, Avon) 30:78-85
Aravindan, Rolands G; Kirn-Safran, Catherine B; Smith, Michelle A et al. (2014) Ultrastructural changes and asthenozoospermia in murine spermatozoa lacking the ribosomal protein L29/HIP gene. Asian J Androl 16:925-6
Kumar, Deepak; Swanik, Charles Buz; Reisman, Darcy S et al. (2014) Individuals with medial knee osteoarthritis show neuromuscular adaptation when perturbed during walking despite functional and structural impairments. J Appl Physiol (1985) 116:13-23

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