This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The long term goal of this project is to understand the mechanisms involved in mitochondrial DNA (mtDNA) maintenance. The overall goal of the present phase is to determine the role played by YGR150c in the preservation of mtDNA. Mitochondrial dysfunction has been long implicated in a number of age-related pathologies, cancer and diabetes. One of the reasons for mitochondrial failure is the damage to, and/or partial or total loss of mtDNA. The loss of the mtDNA renders the cell unable to perform aerobic respiration. mtDNA depletion syndromes (MDS) are a heterogeneous group of severe mitochondrial disorders of infancy and childhood, characterized by a profound reduction in mtDNA copy number. MDS is considered a prevalent cause of multiple respiratory chain deficiency in pediatric patients. However, current genetic screenings relate only to genes involved in maintaining the dNTP pool in mitochondria and explain only 10 % of the cases. The integrity of mtDNA is mainly maintained by nuclear gene products. However, many of the mechanisms that contribute to the preservation of mtDNA are still unclear or unknown. Saccharomyces cerevisiae is an ideal organism with which to study mitochondrial function because it can live without this organelle.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR016476-10
Application #
8360562
Study Section
Special Emphasis Panel (ZRR1-RI-7 (01))
Project Start
2011-06-01
Project End
2012-05-31
Budget Start
2011-06-01
Budget End
2012-05-31
Support Year
10
Fiscal Year
2011
Total Cost
$152,490
Indirect Cost
Name
University of Southern Mississippi
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
623335775
City
Hattiesburg
State
MS
Country
United States
Zip Code
39406
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Rana, Pratip; Dean, Dexter N; Steen, Edward D et al. (2017) Fatty Acid Concentration and Phase Transitions Modulate A? Aggregation Pathways. Sci Rep 7:10370
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Chakraborty, Sandipan; Kumar, Avinash; Butt, Nasir A et al. (2016) Molecular insight into the differential anti-androgenic activity of resveratrol and its natural analogs: in silico approach to understand biological actions. Mol Biosyst 12:1702-9
Chakraborty, S; Asare, B K; Biswas, P K et al. (2016) Designer interface peptide grafts target estrogen receptor alpha dimerization. Biochem Biophys Res Commun 478:116-122

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