This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Work on this project has been ongoing since the summer of 2010. Major accomplishments include: 1.Recruitment of 3 undergraduate and 1 graduate student in research activity. This included the completion of an honors thesis project for one undergraduate student, Jesse Orloff, involving bioinformatic analysis of Slit2. 2. Submission of primary research article publishing the novel findings of Slit2-mediated regulation of hematopoietic stem cells. The manuscript has been reviewed and is currently under revision for the journal Blood. 3. Student research activities include: a. Jesse Orloff i. completion of honors thesis ?""""""""Determination of Expression Profiles and Regulatory Elements for Slit2 with Gene Expression and Genomic Databases"""""""" ii. submission of abstract for Experimental Biology - """"""""Determination of Expression Profiles and Regulatory Elements for Slit2 with Gene Expression and Genomic Databases"""""""" iii. work as lab assistant b. Sam Handshoe i. evaluating effects of Slit2 on NIH-3T3 cell growth c. Johnna Sizemore i. Designing primers for analysis of SNPs in the regulatory regions of the Slit2 gene in mice d. Abagail Cornette i. Designing experiments for Masters thesis to evaluate the effects of Slit2 on cell cycle activity

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR016481-11
Application #
8360124
Study Section
Special Emphasis Panel (ZRR1-RI-4 (01))
Project Start
2011-05-01
Project End
2012-04-30
Budget Start
2011-05-01
Budget End
2012-04-30
Support Year
11
Fiscal Year
2011
Total Cost
$33,223
Indirect Cost
Name
University of Louisville
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
057588857
City
Louisville
State
KY
Country
United States
Zip Code
40292
Green, Kimberly A; Becker, Yvonne; Fitzsimons, Helen L et al. (2016) An Epichloë festucae homologue of MOB3, a component of the STRIPAK complex, is required for the establishment of a mutualistic symbiotic interaction with Lolium perenne. Mol Plant Pathol 17:1480-1492
Saikkonen, Kari; Young, Carolyn A; Helander, Marjo et al. (2016) Endophytic Epichloë species and their grass hosts: from evolution to applications. Plant Mol Biol 90:665-75
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Harrison, Benjamin J; Venkat, Gayathri; Lamb, James L et al. (2016) The Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity. J Neurosci 36:4259-75
Becker, Yvonne; Eaton, Carla J; Brasell, Emma et al. (2015) The Fungal Cell-Wall Integrity MAPK Cascade Is Crucial for Hyphal Network Formation and Maintenance of Restrictive Growth of Epichloë festucae in Symbiosis With Lolium perenne. Mol Plant Microbe Interact 28:69-85
Gemmell, Amber P; Marcus, Jeffrey M (2015) A tale of two haplotype groups: Evaluating the New World Junonia ring species hypothesis using the distribution of divergent COI haplotypes. Syst Entomol 40:532-546

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