Our COBRE, """"""""Mentoring Neuroscience in Louisiana: A Biomedical Program to Enhance Neuroscience in an IdeA State,"""""""" has established a culture of scientific excellence at LSUHSC, Tulane University, and other Louisiana institutions of higher education. Neurosciences research performed in this environment is greatly synergized with respect to both quality and productivity;this new culture is playing a critical role in innovative and fundamentally important research breakthroughs in the neurosciences at our institutions. Recognizing the significance of the mentoring process for developing Promising Junior investigators (PJI) and for strengthening the research infrastructure, we now propose a mechanism to further invigorate the mentoring process in order to solidify a self-sustaining system that will enhance individual and collective research effectiveness. Through our """"""""culture of mentoring"""""""" approach, we propose to (1) involve all participating scientists in the COBRE grant in the development of a comprehensive Louisiana Center for Neuroscience;(2) support four main research projects and five pilot projects by PJIs;(3) continue to support and develop five vital Core facilities;and (4) continue to strengthen the quality of neuroscience research in Louisiana. In the context of our scientific focus - Cellular and Molecular Bases of Synaptic Plasticity, Regulation, and Function - the PJIs'projects are designed to contribute insights into dendritic function, neural information processing, and mechanisms of neuroprotection relevant to epilepsy, ischemia-reperfusion, deafness, and neurodegenerative diseases. Our seven COBRE Core resources - Imaging of Cell Physiology, Molecular Biology, Computational Neurosciences, Lipidomics, Biostastitics, Cell Biology/Tissue Culture and Proteomics- are selected to support this scientific focus. Our COBRE mentoring plan - teams of mentors including junior mentors (successful former PJIs) - aims to produce R01 applications by the PJIs within the second year of the award, and is coupled with a recruitment plan to attract new research faculty at the participating institutions over Years 3 to 5. Our 'grantsmanship-plan'is designed to guide the PJIs to become competitive in the application and peer-review process. We view the four target faculty, the four to-be-recruited faculty, and additional PJIs as the critical building blocks to reinforce and energize a strong neuroscience research environment throughout the State of Louisiana.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR016816-09
Application #
7764778
Study Section
Special Emphasis Panel (ZRR1-RI-8 (01))
Program Officer
Liu, Yanping
Project Start
2002-02-23
Project End
2012-01-31
Budget Start
2010-02-01
Budget End
2011-01-31
Support Year
9
Fiscal Year
2010
Total Cost
$2,112,231
Indirect Cost
Name
Louisiana State Univ Hsc New Orleans
Department
Neurology
Type
Schools of Medicine
DUNS #
782627814
City
New Orleans
State
LA
Country
United States
Zip Code
70112
Ponnath, Abhilash; Farris, Hamilton E (2014) Sound-by-sound thalamic stimulation modulates midbrain auditory excitability and relative binaural sensitivity in frogs. Front Neural Circuits 8:85
Ferland, Chantelle L; Harris, Erin P; Lam, Mai et al. (2014) Facilitation of the HPA axis to a novel acute stress following chronic stress exposure modulates histone acetylation and the ERK/MAPK pathway in the dentate gyrus of male rats. Endocrinology 155:2942-52
Renner, Nicole A; Sansing, Hope A; Inglis, Fiona M et al. (2013) Transient acidification and subsequent proinflammatory cytokine stimulation of astrocytes induce distinct activation phenotypes. J Cell Physiol 228:1284-94
Harrison, L M; Muller, S H; Spano, D (2013) Effects of the Ras homolog Rhes on Akt/protein kinase B and glycogen synthase kinase 3 phosphorylation in striatum. Neuroscience 236:21-30
Ferland, Chantelle L; Hawley, Wayne R; Puckett, Rosemary E et al. (2013) Sirtuin activity in dentate gyrus contributes to chronic stress-induced behavior and extracellular signal-regulated protein kinases 1 and 2 cascade changes in the hippocampus. Biol Psychiatry 74:927-35
Ponnath, Abhilash; Hoke, Kim L; Farris, Hamilton E (2013) Stimulus change detection in phasic auditory units in the frog midbrain: frequency and ear specific adaptation. J Comp Physiol A Neuroethol Sens Neural Behav Physiol 199:295-313
Jones, Patricia L; Farris, Hamilton E; Ryan, Michael J et al. (2013) Do frog-eating bats perceptually bind the complex components of frog calls? J Comp Physiol A Neuroethol Sens Neural Behav Physiol 199:279-83
Imaizumi, Kazuo; Shih, Jonathan Y; Farris, Hamilton E (2013) Global hyper-synchronous spontaneous activity in the developing optic tectum. Sci Rep 3:1552
Lentz, Jennifer J; Jodelka, Francine M; Hinrich, Anthony J et al. (2013) Rescue of hearing and vestibular function by antisense oligonucleotides in a mouse model of human deafness. Nat Med 19:345-50
Harrison, Laura M (2012) Rhes: a GTP-binding protein integral to striatal physiology and pathology. Cell Mol Neurobiol 32:907-18

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