This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff.
The aims are as follows: 1) K3/DR/C regulates dentate granule cell synaptic plasticity at the perforant path/dentate granule cell synapse. 2) Determine whether release of Ca2+ from intracellular stores is sufficient and Ca2+ binding to EF hands is necessary to cause nuclear translocation of K3/DR/C in neurons. 3) Determine whether direct phosphorylation of K3/DR/C by kinases modulates DNA binding properties and gene transcription.
|Ponnath, Abhilash; Farris, Hamilton E (2014) Sound-by-sound thalamic stimulation modulates midbrain auditory excitability and relative binaural sensitivity in frogs. Front Neural Circuits 8:85|
|Ferland, Chantelle L; Harris, Erin P; Lam, Mai et al. (2014) Facilitation of the HPA axis to a novel acute stress following chronic stress exposure modulates histone acetylation and the ERK/MAPK pathway in the dentate gyrus of male rats. Endocrinology 155:2942-52|
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|Harrison, L M; Muller, S H; Spano, D (2013) Effects of the Ras homolog Rhes on Akt/protein kinase B and glycogen synthase kinase 3 phosphorylation in striatum. Neuroscience 236:21-30|
|Ferland, Chantelle L; Hawley, Wayne R; Puckett, Rosemary E et al. (2013) Sirtuin activity in dentate gyrus contributes to chronic stress-induced behavior and extracellular signal-regulated protein kinases 1 and 2 cascade changes in the hippocampus. Biol Psychiatry 74:927-35|
|Ponnath, Abhilash; Hoke, Kim L; Farris, Hamilton E (2013) Stimulus change detection in phasic auditory units in the frog midbrain: frequency and ear specific adaptation. J Comp Physiol A Neuroethol Sens Neural Behav Physiol 199:295-313|
|Jones, Patricia L; Farris, Hamilton E; Ryan, Michael J et al. (2013) Do frog-eating bats perceptually bind the complex components of frog calls? J Comp Physiol A Neuroethol Sens Neural Behav Physiol 199:279-83|
|Imaizumi, Kazuo; Shih, Jonathan Y; Farris, Hamilton E (2013) Global hyper-synchronous spontaneous activity in the developing optic tectum. Sci Rep 3:1552|
|Lentz, Jennifer J; Jodelka, Francine M; Hinrich, Anthony J et al. (2013) Rescue of hearing and vestibular function by antisense oligonucleotides in a mouse model of human deafness. Nat Med 19:345-50|
|Harrison, Laura M (2012) Rhes: a GTP-binding protein integral to striatal physiology and pathology. Cell Mol Neurobiol 32:907-18|
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