This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Vascular and Cardiac Function Core provides space, facilities, supervision and training for COBRE investigators who use animal models of cardiovascular disease and/or in vivo technology to answer specific aims outlined in their research projects. This Core is under the direction of Dr. Kurt Varner, who has over 20 years of experience in cardiovascular physiology and pharmacology. Dr. Varner works closely with the junior and developing investigators in experimental design and data analysis and interpretation. The core provides services for the design and development of new animal models for cardiovascular research. The services of the Core encompass;1) ultrasound imaging, 2) radio telemetry, 3) cardiac pressure-volume analysis, 4) microinjection, 5) sympathetic nerve recording, 6) tissue collection, and 7) blood flow analysis.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR018766-09
Application #
8360495
Study Section
Special Emphasis Panel (ZRR1-RI-6 (01))
Project Start
2011-07-01
Project End
2012-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
9
Fiscal Year
2011
Total Cost
$167,894
Indirect Cost
Name
Louisiana State Univ Hsc New Orleans
Department
Pharmacology
Type
Schools of Medicine
DUNS #
782627814
City
New Orleans
State
LA
Country
United States
Zip Code
70112
Mukerjee, Snigdha; Zhu, Yun; Zsombok, Andrea et al. (2018) Perinatal Exposure to Western Diet Programs Autonomic Dysfunction in the Male Offspring. Cell Mol Neurobiol 38:233-242
Li, Li; Bai, Shi; Sheline, Christian T (2017) hZnT8 (Slc30a8) Transgenic Mice That Overexpress the R325W Polymorph Have Reduced Islet Zn2+ and Proinsulin Levels, Increased Glucose Tolerance After a High-Fat Diet, and Altered Levels of Pancreatic Zinc Binding Proteins. Diabetes 66:551-559
Hou, Xuwei; Snarski, Patricia; Higashi, Yusuke et al. (2017) Nuclear complex of glyceraldehyde-3-phosphate dehydrogenase and DNA repair enzyme apurinic/apyrimidinic endonuclease I protect smooth muscle cells against oxidant-induced cell death. FASEB J 31:3179-3192
El Hajj, Elia C; El Hajj, Milad C; Ninh, Van K et al. (2016) Cardioprotective effects of lysyl oxidase inhibition against volume overload-induced extracellular matrix remodeling. Exp Biol Med (Maywood) 241:539-49
Carmichael, C Y; Carmichael, A C T; Kuwabara, J T et al. (2016) Impaired sodium-evoked paraventricular nucleus neuronal activation and blood pressure regulation in conscious Sprague-Dawley rats lacking central G?i2 proteins. Acta Physiol (Oxf) 216:314-29
Cardenas, Daviel; Carter, Pamela M; Nation, Catherine S et al. (2015) LACK, a RACK1 ortholog, facilitates cytochrome c oxidase subunit expression to promote Leishmania major fitness. Mol Microbiol 96:95-109
Sukhanov, Sergiy; Snarski, Patricia; Vaughn, Charlotte et al. (2015) Insulin-like growth factor I reduces lipid oxidation and foam cell formation via downregulation of 12/15-lipoxygenase. Atherosclerosis 238:313-20
Breslin, Jerome W; Zhang, Xun E; Worthylake, Rebecca A et al. (2015) Involvement of local lamellipodia in endothelial barrier function. PLoS One 10:e0117970
Kurtz, Kristine H; Moor, Andrea N; Souza-Smith, Flavia M et al. (2014) Involvement of H1 and H2 receptors and soluble guanylate cyclase in histamine-induced relaxation of rat mesenteric collecting lymphatics. Microcirculation 21:593-605
Lu, Jingning; Auduong, Linda; White, Eric S et al. (2014) Up-regulation of heparan sulfate 6-O-sulfation in idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol 50:106-14

Showing the most recent 10 out of 141 publications