Abstract

Our oversight plan for AR3T will ensure swift and directed progress towards our goals of (1) providing didactic training that exposes rehabilitation researchers to cutting-edge investigations and state-of-the-art technologies; (2) Driving the science underlying Regenerative Rehabilitation by cultivating collaborative opportunities; (3) Launching a pilot funding program to support novel lines of Regenerative Rehabilitation investigation; and (4) Developing technologies to elucidate the stem cell response to mechanical signals Toward this end, the specific aims of the Administrative Oversight Plan are: 1. To create an internal administrative structure and data management process that is flexible, dynamic and enables effective communication across all sites and 2. To create an External Advisory Board (EAB) that will oversee AR3T operations/activities, ensure the timely and efficient utilization of resources, and provide recommendations for strategic direction of efforts.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Resource-Related Research Multi-Component Projects and Centers (P2C)
Project #
5P2CHD086843-02
Application #
9145759
Study Section
Special Emphasis Panel (ZHD1-DSR-T)
Project Start
Project End
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
2
Fiscal Year
2016
Total Cost
$432,416
Indirect Cost
$46,131

  Institution

Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Nakayama, Karina H; Alcazar, Cynthia; Yang, Guang et al. (2018) Rehabilitative exercise and spatially patterned nanofibrillar scaffolds enhance vascularization and innervation following volumetric muscle loss. NPJ Regen Med 3:16
Begam, Morium; Roche, Joseph A (2018) Damaged muscle fibers might masquerade as hybrid fibers - a cautionary note on immunophenotyping mouse muscle with mouse monoclonal antibodies. Eur J Histochem 62:
Loghmani, M Terry; Roche, Joseph A (2018) Conference Report: 6th Annual International Symposium on Regenerative Rehabilitation. Regen Med 13:371-374
Greising, Sarah M; Warren, Gordon L; Southern, W Michael et al. (2018) Early rehabilitation for volumetric muscle loss injury augments endogenous regenerative aspects of muscle strength and oxidative capacity. BMC Musculoskelet Disord 19:173
LeSavage, Bauer L; Suhar, Nicholas A; Madl, Christopher M et al. (2018) Production of Elastin-like Protein Hydrogels for Encapsulation and Immunostaining of Cells in 3D. J Vis Exp :
Rando, Thomas A; Ambrosio, Fabrisia (2018) Regenerative Rehabilitation: Applied Biophysics Meets Stem Cell Therapeutics. Cell Stem Cell 22:306-309
Quarta, Marco; Cromie, Melinda; Chacon, Robert et al. (2017) Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss. Nat Commun 8:15613
Moritz, Chet T; Ambrosio, Fabrisia (2017) Regenerative Rehabilitation: Combining Stem Cell Therapies and Activity-Dependent Stimulation. Pediatr Phys Ther 29 Suppl 3:S10-S15
Tang, Huibin; L Kennedy, Catherine; Lee, Myung et al. (2017) Smad3 initiates oxidative stress and proteolysis that underlies diaphragm dysfunction during mechanical ventilation. Sci Rep 7:14530
Roche, Joseph A; Begam, Morium; Galen, Sujay S (2017) Minimally Invasive Muscle Embedding (MIME) - A Novel Experimental Technique to Facilitate Donor-Cell-Mediated Myogenesis. J Vis Exp :

Showing the most recent 10 out of 11 publications