The Neuropathology (NP) Core of this ADCC will provide for post-mortem diagnoses on patients and control subjects enrolled in the clinical core and on other well-documented AD cases and controls. The protocols used by the NP aim to be state of the art and consistent with 21st century brain banking procedures, which is essential to met the increasingly sophisticated needs of the AD research community {3922, 3921, 3920, 3919, 3918}. The tissue of the NP core is banked and distributed for research purposes as determined by the Tissue Utilization Committee, while protecting the privacy of research subjects. Part of this NP core and unchanged from the prior grant period, is a Morphometric Component performed at the Institute for Basic Research (IBR) on Staten Island. The Morphometric Component of this core is essential for the careful characterization of AD and control brain tissue in terms of the volume of different brain structures, number of neurons, glial cells, amyloid load and neurons with neurofibrillary change. This information can then be used for precise clinico-pathological correlation.
The Specific Aims of this Neuropathology Core are: 1 .To conduct thorough postmortem examinations on NYU ADCC patients (N=25-30/yr from NYU) using the NIA-Reagan Institute Working Group criteria for the diagnosis of AD. 2.To maintain a bank of unfixed frozen and fixed tissue from the ADCC control and patients with AD or other dementing neurodegenerative conditions. 3.To provide tissue from control brains, AD and other neurodegenerative conditions to AD and prion researchers within and outside this ADCC in order to augment clinical and basic research on dementia. 4.To conduct morphometric studies on AD to establish better clinical neuropathological correlation, in particular to document the progression of the earlier stages of AD pathology. 5.To conduct anatomic and pathologic correlation with in vivo and post mortem MR scans in collaboration with the Neuroimaging Core. 6.To collaborate in the research efforts of the other cores and projects of the ADCC, as well as providing advice and facilities to investigators within and outside the ADCC who seek to conduct morphometric, immunohistochemical of demented and control patients using post-mortem tissue.

Public Health Relevance

The NP core functions to provide essential neuropathological and morphometric characterization of patients who are followed in the clinical core, to allow for clinico-pathological correlations. In addition, it serves to provide tissue for numerous NIH funded AD and prion researchers. The NP core also serves as a resources for peforming studies on AD human and mouse model tissue.

National Institute of Health (NIH)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
New York University
New York
United States
Zip Code
Galvin, James E; Tolea, Magdalena I; George, Nika et al. (2014) Public-private partnerships improve health outcomes in individuals with early stage Alzheimer's disease. Clin Interv Aging 9:621-30
Grill, Joshua D; Galvin, James E (2014) Facilitating Alzheimer disease research recruitment. Alzheimer Dis Assoc Disord 28:1-8
Salloway, Stephen; Sperling, Reisa; Fox, Nick C et al. (2014) Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease. N Engl J Med 370:322-33
Mosconi, Lisa; Murray, John; Tsui, Wai H et al. (2014) Brain imaging of cognitively normal individuals with 2 parents affected by late-onset AD. Neurology 82:752-60
Sabharwal, Priyanka; Wisniewski, Thomas (2014) Novel immunological approaches for the treatment of Alzheimer's disease. Zhongguo Xian Dai Shen Jing Ji Bing Za Zhi 14:139-151
Zhang, Ying; Shi, Zhihong; Liu, Mengyuan et al. (2014) Prevalence of cognitive impairment no dementia in a rural area of Northern China. Neuroepidemiology 42:197-203
Butler, Tracy; Zaborszky, Laszlo; Pirraglia, Elizabeth et al. (2014) Comparison of human septal nuclei MRI measurements using automated segmentation and a new manual protocol based on histology. Neuroimage 97:245-51
Reisberg, Barry; Monteiro, Isabel; Torossian, Carol et al. (2014) The BEHAVE-AD assessment system: a perspective, a commentary on new findings, and a historical review. Dement Geriatr Cogn Disord 38:89-146
Iulita, M Florencia; Do Carmo, Sonia; Ower, Alison K et al. (2014) Nerve growth factor metabolic dysfunction in Down's syndrome brains. Brain 137:860-72
Jessen, Frank; Amariglio, Rebecca E; van Boxtel, Martin et al. (2014) A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease. Alzheimers Dement 10:844-52

Showing the most recent 10 out of 189 publications