Research during the last 5 years has uniquely positioned the University of California, Davis Alzheimer's Disease Center (UCD ADC) to advance scientific understanding along the theme of how various risk and protective conditions differentially affect cognitive trajectories across the spectrum of cognitive ability. Our approach is enabled and enhanced by the unique experiences, skills, and methods facilitated by the UCD ADC Cores and their interactions. These skills include development or refinement of new methods along with development of new conceptual models and the coordinated application of these resources towards common goals. These efforts are further extended by extensive collaborations with other scientists, NACC and the NIA. Importantly, these efforts are part of an integrated and growing research program at UC Davis that is uniquely suited to studying the complex determinants of cognitive decline associated with diseases of aging and dementia. Consisting of 6 Cores, the UCD ADC approach to supporting ongoing research is based on the belief that AD exists within the wider context of other factors that affect cognitive function. Unraveling the multiple deleterious and protective factors that ultimately determine the variance in course of cognitive function with advancing age, however, remains an enormous challenge. To meet this challenge, the Clinical Core developed methods to enhance subject diversity amongst the participants within the longitudinal cohort of the UCD ADC leading to recruitment of a highly diverse study population that varies across multiple dimensions. We also developed novel assessment tools which were used to acquire further research funding in support of the general themes and available resources of the UCD ADC. This approach, built around a diverse and longitudinally followed cohort of subjects, serves as the core resource for an integrated research effort that is guided by five essential principals: innovation, integration, leverage, growth and training. In this application we present successful progress over the previous grant cycle and propose nbvel and unique approaches to guide the succeeding five years in order to continue to productively contribute to advancing our understanding of conditions the influence cognitive aging and incident dementia.

Public Health Relevance

A variety of protective and risk conditions exist and combine to result in widely varying trajectories of cognitive aging. Understanding the sources for this heterogeneity is a central issue to research that has both scientific significance and clinical relevance, including relevance for potential treatment. Unraveling the multiple deleterious and protective factors that ultimately determine the variance in course of cognitive function with advancing aae is the goal of the UCD ADC.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-5 (M2))
Program Officer
Silverberg, Nina B
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Davis
Schools of Medicine
United States
Zip Code
Rueda, Alicia D; Lau, Karen M; Saito, Naomi et al. (2015) Self-rated and informant-rated everyday function in comparison to objective markers of Alzheimer's disease. Alzheimers Dement 11:1080-9
Caroli, Anna; Prestia, Annapaola; Wade, Sara et al. (2015) Alzheimer Disease Biomarkers as Outcome Measures for Clinical Trials in MCI. Alzheimer Dis Assoc Disord 29:101-9
Mah, Linda; Binns, Malcolm A; Steffens, David C et al. (2015) Anxiety symptoms in amnestic mild cognitive impairment are associated with medial temporal atrophy and predict conversion to Alzheimer disease. Am J Geriatr Psychiatry 23:466-76
Dmitrieva, Natalia O; Fyffe, Denise; Mukherjee, Shubhabrata et al. (2015) Demographic characteristics do not decrease the utility of depressive symptoms assessments: examining the practical impact of item bias in four heterogeneous samples of older adults. Int J Geriatr Psychiatry 30:88-96
Sisco, Shannon; Gross, Alden L; Shih, Regina A et al. (2015) The role of early-life educational quality and literacy in explaining racial disparities in cognition in late life. J Gerontol B Psychol Sci Soc Sci 70:557-67
Bertens, Daniela; Knol, Dirk L; Scheltens, Philip et al. (2015) Temporal evolution of biomarkers and cognitive markers in the asymptomatic, MCI, and dementia stage of Alzheimer's disease. Alzheimers Dement 11:511-22
Melrose, Rebecca J; Brewster, Paul; Marquine, MarĂ­a J et al. (2015) Early life development in a multiethnic sample and the relation to late life cognition. J Gerontol B Psychol Sci Soc Sci 70:519-31
Teng, Edmond; Chow, Nicole; Hwang, Kristy S et al. (2015) Low plasma ApoE levels are associated with smaller hippocampal size in the Alzheimer's disease neuroimaging initiative cohort. Dement Geriatr Cogn Disord 39:154-66
Qiu, Yue; Li, Liang; Zhou, Tian-yan et al. (2014) Alzheimer's disease progression model based on integrated biomarkers and clinical measures. Acta Pharmacol Sin 35:1111-20
Kim, Jong Hun; Song, Pamela; Lim, Hyunsun et al. (2014) Gene-based rare allele analysis identified a risk gene of Alzheimer's disease. PLoS One 9:e107983

Showing the most recent 10 out of 579 publications