The Neuroimaging Core (NC) plays an integral role in addressing the UCD ADC scientific theme by providing imaging-based biological markers of disease processes that damage brain structure and function and ultimately impact cognitive trajectories across a broad spectrum of ability. Building on the success of our two previous cycles of funded activities, the NC will continue to provide a set of core services related to acquisition, post-processing, storage, and dissemination of imaging data. In addition, the NC will continue to collaborate with neuroimaging institutions at UC Davis to incorporate novel state-of-the-art methods that further its scientific mission to make precise measurements of the natural course of late-life brain injury.
The Aims of the NC reflect a steady progression of the capabilities of the NC over time, and the Core is now a tightly-integrated component of the Center that enriches the other Cores and the AD research community. Specifically, the NC now provides raw images to the Clinical and Neuropathology Cores (CC and NPC) to support diagnostic activities, and provides validated, state-of-the-art measurements of brain structure and function to the Data Management and Statistics Core (DMSC) in support of research projects. The NC also participates in large-scale multi-site imaging studies and provides imaging data that promotes novel AD research. The NC also works with the Education and Information Transfer Core (EITC) to train investigators in neuroimaging methods and disseminate imaging related research advances. While the NC has limited resources, the images and imaging-based numerical measurements it collects are widely disseminated and utilized. This leveraging of resources enhances research productivity broadly and amplifies the initial investment in image acquisition. Thus, the NC provides benefits that extend far beyond the level of Core funding or support from individual research projects.
The UCD ADC focuses on factors that influence heterogeneity of late-life cognitive trajectories. Because longitudinal courses of brain injury play a key role in determining these trajectories, neuroimaging technologies that provide proxy measures of neuronal dysfunction and death are central to the scientific mission of the Center. The NC is an international leader in image-based measurement of these properties
|Meyer, Oanh L; Leggett, Amanda; Liu, Siwei et al. (2017) Prevalence and correlates of subjective memory complaints in Vietnamese adults. Int Psychogeriatr :1-10|
|Montgomery, Valencia; Harris, Katie; Stabler, Anthony et al. (2017) Effects of Delay Duration on the WMS Logical Memory Performance of Older Adults with Probable Alzheimer's Disease, Probable Vascular Dementia, and Normal Cognition. Arch Clin Neuropsychol 32:375-380|
|Katsumata, Yuriko; Nelson, Peter T; Ellingson, Sally R et al. (2017) Gene-based association study of genes linked to hippocampal sclerosis of aging neuropathology: GRN, TMEM106B, ABCC9, and KCNMB2. Neurobiol Aging 53:193.e17-193.e25|
|Weintraub, Sandra; Besser, Lilah; Dodge, Hiroko H et al. (2017) Version 3 of the Alzheimer Disease Centers' Neuropsychological Test Battery in the Uniform Data Set (UDS). Alzheimer Dis Assoc Disord :|
|Meyer, Oanh L; Liu, Xiaoyan Lucia; Tancredi, Daniel et al. (2017) Acculturation level and caregiver outcomes from a randomized intervention trial to enhance caregivers' health: evidence from REACH II. Aging Ment Health :1-8|
|Brenowitz, Willa D; Keene, C Dirk; Hawes, Stephen E et al. (2017) Alzheimer's disease neuropathologic change, Lewy body disease, and vascular brain injury in clinic- and community-based samples. Neurobiol Aging 53:83-92|
|Wang, Bo-Jeng; Her, Guor Mour; Hu, Ming-Kuan et al. (2017) ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer's disease. Proc Natl Acad Sci U S A 114:E3129-E3138|
|Meyer, Oanh L; Liu, Xiaoyan; Nguyen, Thuc-Nhi et al. (2017) Psychological Distress of Ethnically Diverse Adult Caregivers in the California Health Interview Survey. J Immigr Minor Health :|
|Romero, José R; Beiser, Alexa; Himali, Jayandra J et al. (2017) Cerebral microbleeds and risk of incident dementia: the Framingham Heart Study. Neurobiol Aging 54:94-99|
|Moga, Daniela C; Abner, Erin L; Wu, Qishan et al. (2017) Bladder antimuscarinics and cognitive decline in elderly patients. Alzheimers Dement (N Y) 3:139-148|
Showing the most recent 10 out of 1057 publications