The Indiana Alzheimer Disease Center (lADC) is established on the campus of Indiana University School of Medicine. It is comprised of six cores: Administrative Core, Clinical Core, Data Management and Statistics Core, Neuropathology Core, Education and Information Transfer Core and Neuroimaging Core. The mission of the lADC is: 1) to support and carry out research on Alzheimer disease (AD) and other neurodegenerative dementias, 2) to serve as shared research resources that will facilitate research in AD and other dementias, 3)distinguish them from the processes of normal brain aging and mild cognitive impairment (MCI), 4) provide a platform for training, 5) develop novel techniques and methodologies, and 6) translate these research findings into better diagnostic, prevention and treatment strategies. The focus of the lADC is on behavioral neurology, clinico- pathological correlations, biochemistry, and genetics of AD, front temporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17), Gerstmann-Straussler-Schelnker disease (GSS), Parkinson disease and other hereditary diseases associated with abnormal protein accumulation.

Public Health Relevance

It is estimated that as many as 5 million Americans have AD. The Indiana Alzheimer Disease Center provides an environment and resources directed towards fostering and coordinating research and educational activities on AD and other dementing illnesses.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
2P30AG010133-21
Application #
8174021
Study Section
Special Emphasis Panel (ZAG1-ZIJ-5 (M2))
Program Officer
Silverberg, Nina B
Project Start
1997-07-15
Project End
2016-06-30
Budget Start
2011-08-15
Budget End
2012-06-30
Support Year
21
Fiscal Year
2011
Total Cost
$1,763,493
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Pathology
Type
Schools of Medicine
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Deming, Yuetiva; Dumitrescu, Logan; Barnes, Lisa L et al. (2018) Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathol 136:857-872
Brenowitz, Willa D; Han, Fang; Kukull, Walter A et al. (2018) Treated hypothyroidism is associated with cerebrovascular disease but not Alzheimer's disease pathology in older adults. Neurobiol Aging 62:64-71
Lee, Younghee; Han, Seonggyun; Kim, Dongwook et al. (2018) Genetic variation affecting exon skipping contributes to brain structural atrophy in Alzheimer's disease. AMIA Jt Summits Transl Sci Proc 2017:124-131
Kinnunen, Kirsi M; Cash, David M; Poole, Teresa et al. (2018) Presymptomatic atrophy in autosomal dominant Alzheimer's disease: A serial magnetic resonance imaging study. Alzheimers Dement 14:43-53
Wachinger, Christian; Nho, Kwangsik; Saykin, Andrew J et al. (2018) A Longitudinal Imaging Genetics Study of Neuroanatomical Asymmetry in Alzheimer's Disease. Biol Psychiatry 84:522-530
Tometich, Danielle; Small, Brent J; Carroll, Judith E et al. (2018) Pre-treatment psychoneurological symptoms and their association with longitudinal cognitive function and quality of life in older breast cancer survivors. J Pain Symptom Manage :
Hendrie, Hugh C; Zheng, Mengjie; Lane, Kathleen A et al. (2018) Changes of glucose levels precede dementia in African-Americans with diabetes but not in Caucasians. Alzheimers Dement 14:1572-1579
Gallagher, Damien; Kiss, Alex; Lanctot, Krista L et al. (2018) Toward Prevention of Mild Cognitive Impairment in Older Adults With Depression: An Observational Study of Potentially Modifiable Risk Factors. J Clin Psychiatry 80:
Wang, Sophia; Hammes, Jessica; Khan, Sikandar et al. (2018) Improving Recovery and Outcomes Every Day after the ICU (IMPROVE): study protocol for a randomized controlled trial. Trials 19:196
Falcon, Benjamin; Zhang, Wenjuan; Murzin, Alexey G et al. (2018) Structures of filaments from Pick's disease reveal a novel tau protein fold. Nature 561:137-140

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