The aims of the Neuropathology Core are to provide technical resources, laboratory facilities and professional expertise for the collection, diagnosis and storage of tissue obtained at autopsy from patients with dementia and control subjects studied in the Clinical Core, National Cell Repository for Alzheimer's Disease (NCRAD), the Late Onset Alzheimer Disease project (LOAD), other Alzheimer disease centers (ADCs), the frontotemporal dementia (FTD) project of the NINDS, Parkinson Research: the Organized Genetics Initiative (PROGENI), and academic institutions as well as families from the community including those referred by the Alzheimer's Association chapters. The Neuropathology Core will provide information about pathologic data to referring physicians and families as well as well-characterized tissue to basic researchers. In addition, the Core will be involved in continuing education to physicians, researchers, technicians and the community about new developments emerging from Alzheimer disease (AD) research. Our understanding of the clinical, pathologic and molecular aspects of AD and other dementias has advanced rapidly. Brain tissue of demented individuals must be studied for diagnostic and research purposes using a multidisciplinary approach. We have expanded our Dementia Laboratory for degenerative brain diseases and our tissue repository. The Core has contributed to the investigations of hereditary presenile dementias by (1) characterizing familial AD with mutations in the APP, and PSENI genes, (ii) characterizing the neuropathoiogic phenotypes of sporadic and hereditary prion diseases, (iii) characterizing the neuropathoiogic phenotypes of frontotemporal dementia associated with MAPT, granulin, TDP-43 (iv) discovering novel mutations in APP, PSENI, PRNP, MAPT, Granulin, TDP-43, Ferritin Light Polypeptide and Neuroserpin genes as well as unclassified forms of presenile dementia. We have expanded our mission integrating molecular technology to assist in the neuropathoiogic diagnosis. We are combining data obtained by neurohistology, immunohistochemistry and immunocytochemistry to recognize and characterize the localization and the antigenic profile of molecules that are important to the pathogenesis of dementia. These studies carried out in parallel with molecular analysis are fundamental to understand disease etiology and phenotypic heterogeneity. We consider this multidisciplinary approach to be the hallmark of the IADC Neuropathology Core and will aid us in providing a definitive diagnosis of dementing disorders.

Public Health Relevance

It is estimated that as many as 5 million Americans have AD. The Indiana Alzheimer Disease Center provides an environment and resources directed towards fostering and coordinating research and educational activities on AD and other dementing illnesses.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG010133-23
Application #
8502593
Study Section
Special Emphasis Panel (ZAG1-ZIJ-5)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
23
Fiscal Year
2013
Total Cost
$231,065
Indirect Cost
$81,022
Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Chapman, Kimberly R; Bing-Canar, Hanaan; Alosco, Michael L et al. (2016) Mini Mental State Examination and Logical Memory scores for entry into Alzheimer's disease trials. Alzheimers Res Ther 8:9
Kovacs, Gabor G; Ferrer, Isidro; Grinberg, Lea T et al. (2016) Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy. Acta Neuropathol 131:87-102
Nho, Kwangsik; Saykin, Andrew J (2016) Reply. Ann Neurol 79:335
Lahiri, Debomoy K; Maloney, Bryan; Bayon, Baindu L et al. (2016) Transgenerational latent early-life associated regulation unites environment and genetics across generations. Epigenomics 8:373-87
Ridge, Perry G; Hoyt, Kaitlyn B; Boehme, Kevin et al. (2016) Assessment of the genetic variance of late-onset Alzheimer's disease. Neurobiol Aging 41:200.e13-20
Green, Colin; Zhang, Shenqiu (2016) Predicting the progression of Alzheimer's disease dementia: A multidomain health policy model. Alzheimers Dement 12:776-85
Nudelman, Kelly N H; McDonald, Brenna C; Wang, Yang et al. (2016) Cerebral Perfusion and Gray Matter Changes Associated With Chemotherapy-Induced Peripheral Neuropathy. J Clin Oncol 34:677-83
Ringman, John M; Monsell, Sarah; Ng, Denise W et al. (2016) Neuropathology of Autosomal Dominant Alzheimer Disease in the National Alzheimer Coordinating Center Database. J Neuropathol Exp Neurol 75:284-90
Li, Wei; Risacher, Shannon L; McAllister, Thomas W et al. (2016) Erratum to: Traumatic brain injury and age at onset of cognitive impairment in older adults. J Neurol 263:1286
Jun, G; Ibrahim-Verbaas, C A; Vronskaya, M et al. (2016) A novel Alzheimer disease locus located near the gene encoding tau protein. Mol Psychiatry 21:108-17

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