The central theme of the UT Southwestern ADC is that vascular and inflammatory risk factors in elderly individuals influence the course of AD, MCI and FTLD, and that such factors constitute endophenotypes. A requirement of such endophenotypes is that they be measurable by quantitative psychometric, physiologic, neuroimaging, or biochemical methods. Over the next 5 years, the Clinical Core will carry out studies aimed at developing methods to study these vascular and inflammatory endophenotypes and assess their contribution to AD, MCI, FTLD and normal aging. Our specific hypothesis is that the age of onset and rate of progression of patients presenting with early-stage AD (including MCI) and FTLD are related to the presence of vascular and inflammatory endophenotypes. This hypothesis reflects the interests of Center investigators as well as the expertise of other investigators at UT Southwestern Medical Center. While this theme is our focus, the Clinical Core also functions as a core facility to foster and support investigator-initiated research projects at UT Southwestern that require prospectively collected clinical information and biological fluids, as well as to continue supporting the productive participation by UT Southwestern in multi-institutional collaborative studies. Specifically, the aims of the Clinical Core are as follows: (1). To prospectively follow five longitudinal cohorts of subjects. Four of these cohorts are clinic-based cohorts that we have followed in our Center for several years, and the fifth is a part of population-based cohort added to the ADC during this cycle. (2). To support investigator-initiated research on neurodegenerative dementias by local researchers. (3). To support multi-institutional observational studies and clinical trials in AD, MCI and FTLD.

Public Health Relevance

The development of successful therapies for Alzheimer's disease (AD) will require a thorough understanding of the pathologic mechanisms that contribute to neurodegeneration. Data from epidemiologic and observational studies indicates that vascular and inflammatory pathology contributes to AD. The goal of the UTSW ADC Clinical Core is to identify biomarkers of vascular and inflammatory pathology that will be useful for selection of participants in clinical trials.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG012300-19
Application #
8501178
Study Section
Special Emphasis Panel (ZAG1-ZIJ-5)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
19
Fiscal Year
2013
Total Cost
$611,962
Indirect Cost
$227,080
Name
University of Texas Sw Medical Center Dallas
Department
Type
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
Neu, Scott C; Pa, Judy; Kukull, Walter et al. (2017) Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis. JAMA Neurol 74:1178-1189
Alosco, Michael L; Duskin, Jonathan; Besser, Lilah M et al. (2017) Modeling the Relationships Among Late-Life Body Mass Index, Cerebrovascular Disease, and Alzheimer's Disease Neuropathology in an Autopsy Sample of 1,421 Subjects from the National Alzheimer's Coordinating Center Data Set. J Alzheimers Dis 57:953-968
Pandya, Seema Y; Lacritz, Laura H; Weiner, Myron F et al. (2017) Predictors of Reversion from Mild Cognitive Impairment to Normal Cognition. Dement Geriatr Cogn Disord 43:204-214
Jun, Gyungah R; Chung, Jaeyoon; Mez, Jesse et al. (2017) Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimers Dement 13:727-738
Jutkowitz, Eric; MacLehose, Richard F; Gaugler, Joseph E et al. (2017) Risk Factors Associated With Cognitive, Functional, and Behavioral Trajectories of Newly Diagnosed Dementia Patients. J Gerontol A Biol Sci Med Sci 72:251-258
Jefferson-George, Kyra S; Wolk, David A; Lee, Edward B et al. (2017) Cognitive decline associated with pathological burden in primary age-related tauopathy. Alzheimers Dement 13:1048-1053
Evers, Bret M; Rodriguez-Navas, Carlos; Tesla, Rachel J et al. (2017) Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in Progranulin Deficiency. Cell Rep 20:2565-2574
Qian, Jing; Hyman, Bradley T; Betensky, Rebecca A (2017) Neurofibrillary Tangle Stage and the Rate of Progression of Alzheimer Symptoms: Modeling Using an Autopsy Cohort and Application to Clinical Trial Design. JAMA Neurol 74:540-548
Moga, Daniela C; Taipale, Heidi; Tolppanen, Anna-Maija et al. (2017) A Comparison of Sex Differences in Psychotropic Medication Use in Older People with Alzheimer's Disease in the US and Finland. Drugs Aging 34:55-65
Devanand, Davangere P; Liu, Xinhua; Brown, Patrick J (2017) Impact of Functional Deficits in Instrumental Activities of Daily Living in Mild Cognitive Impairment: A Clinical Algorithm to Predict Progression to Dementia. Alzheimer Dis Assoc Disord 31:55-61

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