This application is for renewal of the Nathan Shock Center of Excellence in the Basic Biology of Aging at the University of Washington and affiliated institutions. This Center has over the past 15 years provided resources in support of our large community of investigators that are funded to study basic biological mechanisms of aging. We continue to build upon a scientific theme that became established in the past funding cycle, in which comparative gerontologic study informed us of conserved genetic pathways of longevity determination (the TOR pathway is an example of one such). The three proposed Research Resources Core components are well suited to assist in such efforts: 1) Transgenic Animal Model Development;2) Functional Assessment;3) Functional Genomics. The Transgenic Animal Model Development Resource Core continues to pursue a focus on inducible gene expression and knockout models, so that organ and age-specific effects of genetic alterations can be assessed. The Functional Assessment Core builds upon technical resources that have been gathered during the past funding period, such that we can now provide investigators with a broad and informative range of physiologic and cellular assays, including those that are most relevant to assessment of the healthspan of mouse models. The Functional Genomics Core provides expert assistance with state of the art technologies for transcriptomics and proteomics. Consistent with our theme, it includes a focus on translational state, protein turnover and post-translational modification. The Research Development Core will continue to support pilot study projects in the basic biology of aging. The Program Enrichment Core supports administrative management, an external advisory panel, a program of courses and seminars and data sharing and dissemination.

Public Health Relevance

Continuation of this Center's support will further the utilization of state-of-the-art research resources to provide the strongest environment for the conduct of research on aging biology at institutions in our geographical neighborhood. It will 1) enhance the quality of research in the basic biology of aging, 2) facilitate the planning and coordination of aging biology research activities, 3) provide support and an enriched environment for investigators new to aging biology and 4) contribute to our being able to provide resources to Biology of Aging investigators across the nation.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-2 (M1))
Program Officer
Sierra, Felipe
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Washington
Schools of Medicine
United States
Zip Code
Ting, Ying S; Egertson, Jarrett D; Bollinger, James G et al. (2017) PECAN: library-free peptide detection for data-independent acquisition tandem mass spectrometry data. Nat Methods 14:903-908
Beaupere, Carine; Wasko, Brian M; Lorusso, Jared et al. (2017) CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes. Cell Rep 18:1884-1892
Dennis, Daniel G; McKay-Fleisch, Jill; Eitzen, Kaila et al. (2017) Normally lethal amino acid substitutions suppress an ultramutator DNA Polymerase ? variant. Sci Rep 7:46535
Bennett, Christopher F; Kwon, Jane J; Chen, Christine et al. (2017) Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans. PLoS Genet 13:e1006695
Russell, Joshua Coulter; Burnaevskiy, Nikolay; Ma, Bridget et al. (2017) Electrophysiological measures of aging pharynx function in C. elegans reveal enhanced organ functionality in older, long-lived mutants. J Gerontol A Biol Sci Med Sci :
Lee, Mitchell B; Carr, Daniel T; Kiflezghi, Michael G et al. (2017) A system to identify inhibitors of mTOR signaling using high-resolution growth analysis in Saccharomyces cerevisiae. Geroscience :
Urfer, Silvan R; Kaeberlein, Tammi L; Mailheau, Susan et al. (2017) A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs. Geroscience 39:117-127
Mendenhall, Alexander; Crane, Matthew M; Leiser, Scott et al. (2017) Environmental Canalization of Life Span and Gene Expression in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 72:1033-1037
Urfer, Silvan R; Kaeberlein, Tammi L; Mailheau, Susan et al. (2017) Asymptomatic heart valve dysfunction in healthy middle-aged companion dogs and its implications for cardiac aging. Geroscience 39:43-50
Kapahi, Pankaj; Kaeberlein, Matt; Hansen, Malene (2017) Dietary restriction and lifespan: Lessons from invertebrate models. Ageing Res Rev 39:3-14

Showing the most recent 10 out of 157 publications