The Research Development Core D provides support for Pilot Projects for junior faculty, or more rarely, more senior faculty who wish to enter the field of aging. Pilot Project Support fulfills two main objectives. First, as shown from our record of past performance, they can be an important part of the support for junior faculty who are embarking on new projects that may not yet have achieved outside funding. Second, and less often, they can play a similar role for more senior faculty who are changing career objectives in order to study the basic biology of aging for the first time. The total award budget is $90,000/yr, distributed as (typically) 6 individual awards. The large majority of awards will be targeted to candidates outside our region. These awards will provide fully subsidized access to our Research Resource Core services, necessary reagents and supplies, mentoring by a senior faculty member, and for external recipients, travel expenses for at least one visit to our Center. This activity is directed by the Core Leader in concert with the Executive Committee of our Nathan Shock Center. We present 1) a plan for the advertising, review and selection of investigators to receive support, 2) a plan for administration of awards, 3) a plan for the career development of individuals who will be selected for these positions, 4) a list of senior faculty who will participate in research career development. We will demonstrate that our institutions are able to provide adequate resources for the support of the research efforts of junior investigators, and a plan for monitoring their progress and development towards career objectives.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG013280-22
Application #
9116750
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
22
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Walters, Ryan O; Arias, Esperanza; Diaz, Antonio et al. (2018) Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans. Cell Rep 25:663-676.e6
Kramer, Philip A; Duan, Jicheng; Gaffrey, Matthew J et al. (2018) Fatiguing contractions increase protein S-glutathionylation occupancy in mouse skeletal muscle. Redox Biol 17:367-376
Kaeberlein, Matt (2018) How healthy is the healthspan concept? Geroscience 40:361-364
Crane, Matthew M; Kaeberlein, Matt (2018) The paths of mortality: how understanding the biology of aging can help explain systems behavior of single cells. Curr Opin Syst Biol 8:25-31
Beaupere, Carine; Dinatto, Leticia; Wasko, Brian M et al. (2018) Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast. Proc Natl Acad Sci U S A 115:9586-9591
Andeen, Nicole K; Yang, Han-Yin; Dai, Dao-Fu et al. (2018) DnaJ Homolog Subfamily B Member 9 Is a Putative Autoantigen in Fibrillary GN. J Am Soc Nephrol 29:231-239
Urfer, Silvan R; Kaeberlein, Tammi L; Mailheau, Susan et al. (2017) Asymptomatic heart valve dysfunction in healthy middle-aged companion dogs and its implications for cardiac aging. Geroscience 39:43-50
Mendenhall, Alexander; Crane, Matthew M; Leiser, Scott et al. (2017) Environmental Canalization of Life Span and Gene Expression in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 72:1033-1037
Beaupere, Carine; Wasko, Brian M; Lorusso, Jared et al. (2017) CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes. Cell Rep 18:1884-1892
Urfer, Silvan R; Kaeberlein, Tammi L; Mailheau, Susan et al. (2017) A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs. Geroscience 39:117-127

Showing the most recent 10 out of 168 publications