Aging is a virtually ubiquitous, progressive degenerative process. However nature has repeatedly produced species with both exceptional resistance, and exceptional susceptibility, to aging. We call these 'species of exceptional biogerontological interest' (= EBl species), because of their potential to inform us both about the identity and nature of the destructive mechanisms that cause senescence as well as protective mechanisms of exceptional resistance to these mechanisms. The comparative biology of aging employs EBl species to address these issues. The overarching goal of the Comparative 8iology of Aging Core is to provide to researchers high quality, hard-to-get biological research materials from EBl species. Among mammals, we define EBl species as those living < 0.7 times as long as expected for their body size (the longevity of a mouse or less) or > 2.5 times as long as expected for its body size (the longevity of an average monkey or more). Additionally, because of their close evolutionary affinity with humans, we consider any primate regardless of longevity an EBl species. An important caveat is that we will only use species for which there is solid and unassailable documentation of longevity.
The Specific Aims of the Comparative Biology of Aging Core are as follows: 1. Procure, crvopreserve. and provide to investigators cells and tissues from EBl species. A critical part of this aim is to ensure that cell culture growth conditions are optimized for each species. A second important component of this aim is to assure that biological materials come from healthy animals of known age. A final critical component to this aim is to communicate to the wider aging research community the availability of these biological materials to interested scientists. 2. Maintain research colonies, or purchase animals or tissues, of selected EBl species.
This aim ensures that samples, even of fresh tissues, may be continuously available to the research community and takes advantage of the exceptional combination of extensive professional contacts in the comparative biology community and expertise in the husbandry of individual EBl species available at UTHSCSA. 3. Provide consultation and feasibility assessment for investigators wishing to pursue comparative aging studies. The Leader and Co-leaders of this core are uniquely positioned in terms of their expertise and contacts within the wider zoological research community to provide information, assessment, and guidance to interested investigators.

Public Health Relevance

This core provides resources to help determine mechanisms that retard aging, with the long-term goal of the development of therapies to slow human aging. This would enhance and preserve human health. Because aging is the ultimate cause of many late life maladies, the research has the potential to not only enhance health but delay and mitigate numerous late life diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG013319-18
Application #
8572569
Study Section
Special Emphasis Panel (ZAG1-ZIJ-2 (M1))
Project Start
1997-07-15
Project End
2015-06-30
Budget Start
2012-07-15
Budget End
2013-06-30
Support Year
18
Fiscal Year
2012
Total Cost
$116,078
Indirect Cost
$38,347
Name
University of Texas Health Science Center San Antonio
Department
Type
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Tarantini, Stefano; Fulop, Gabor A; Kiss, Tamas et al. (2017) Demonstration of impaired neurovascular coupling responses in TG2576 mouse model of Alzheimer's disease using functional laser speckle contrast imaging. Geroscience :
Zhang, Yiqiang; Unnikrishnan, Archana; Deepa, Sathyaseelan S et al. (2017) A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1-/- mice is correlated to increased cellular senescence. Redox Biol 11:30-37
Tavakoli, Sina; Short, John D; Downs, Kevin et al. (2017) Differential Regulation of Macrophage Glucose Metabolism by Macrophage Colony-stimulating Factor and Granulocyte-Macrophage Colony-stimulating Factor: Implications for (18)F FDG PET Imaging of Vessel Wall Inflammation. Radiology 283:87-97
Csiszar, Anna; Tarantini, Stefano; Fülöp, Gábor A et al. (2017) Hypertension impairs neurovascular coupling and promotes microvascular injury: role in exacerbation of Alzheimer's disease. Geroscience :
Bai, Xiang; Wey, Margaret Chia-Ying; Martinez, Paul Anthony et al. (2017) Neurochemical and motor changes in mice with combined mutations linked to Parkinson's disease. Pathobiol Aging Age Relat Dis 7:1267855
McGill-Vargas, Lisa; Gastaldelli, Amalia; Liang, Hanyu et al. (2017) Hepatic Insulin Resistance and Altered Gluconeogenic Pathway in Premature Baboons. Endocrinology 158:1140-1151
Lin, Ai-Ling; Jahrling, Jordan B; Zhang, Wei et al. (2017) Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer's disease. J Cereb Blood Flow Metab 37:217-226
Qi, Wenbo; Gutierrez, Gloria E; Gao, Xiaoli et al. (2017) The ?-3 fatty acid ?-linolenic acid extends Caenorhabditis elegans lifespan via NHR-49/PPAR? and oxidation to oxylipins. Aging Cell 16:1125-1135
Deng, Yilun; Flores, Shahida K; Cheng, ZiMing et al. (2017) Molecular and phenotypic evaluation of a novel germline TMEM127 mutation with an uncommon clinical presentation. Endocr Relat Cancer 24:L79-L82
Ashpole, Nicole M; Logan, Sreemathi; Yabluchanskiy, Andriy et al. (2017) IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan. Geroscience 39:129-145

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