The Northwestern Alzheimer's Disease Center (ADC) Clinical Core is entering its 15th year of operation, having established a valuable resource for innovative clinical research, new initiatives and collaborations with intramural investigators, cross-center studies, and providing patients, caregivers and the community with state-of-the-art diagnostic and treatment services. In the next five years, the Clinical Core will support three main research goals: 1. Maintain a diverse cohort of subjects characterized by the Uniform Data Set (UDS), recruited for brain and tissue donation, and made available for intramural research projects as well as multicenter efforts such as those represented by NACC, ADCS, ADNI and others. Recruitment will target individuals with either mild memory disorders or no cognitive impairment (NCI) and will also emphasize enrollment of participants over age 80 whose cognitive performance exceeds what is average for age, in order to support research not only on the age-MCI-AD spectrum but also on the trajectory of unusually successful cognitive aging (The Northwestern SuperAging Project). 2. Coordinate national recruitment efforts to support specialized research programs for Primary Progressive Aphasia (PPA) and other forms of dementia associated with FTLD, in order to refine diagnostic criteria for these less known and underserved types of dementia, identify their neuropathologic bases in collaboration with the Neuropathology Core, and develop specialized treatments and educational resources, in collaboration with the Education Core. 3. Provide a setting for """"""""therapeutic encounters"""""""" to enhance patient retention and to integrate research programs with innovative patient care recommendations, specifically tailored to the individual patient's profile of cognitive and behavioral impairment.

Public Health Relevance

Alzheimer's disease and related disorders pose a public health crisis in the US. The Clinical Core serves to recruit and characterize cognitively healthy individuals and those with a variety of dementia syndromes to provide investigators at NU and the broader research community with resources for clinical trials for studies of in vivo biomarkers, to identify and treat disease states, and to promote healthy brain aging.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-5)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Northwestern University at Chicago
United States
Zip Code
Gefen, Tamar; Ahmadian, Saman S; Mao, Qinwen et al. (2018) Combined Pathologies in FTLD-TDP Types A and C. J Neuropathol Exp Neurol 77:405-412
Raghanti, Mary Ann; Edler, Melissa K; Stephenson, Alexa R et al. (2018) A neurochemical hypothesis for the origin of hominids. Proc Natl Acad Sci U S A 115:E1108-E1116
Alosco, Michael L; Sugarman, Michael A; Besser, Lilah M et al. (2018) A Clinicopathological Investigation of White Matter Hyperintensities and Alzheimer's Disease Neuropathology. J Alzheimers Dis 63:1347-1360
Brent, Robert J (2018) Estimating the monetary benefits of medicare eligibility for reducing the symptoms of dementia. Appl Econ 50:6327-6340
Deming, Yuetiva; Dumitrescu, Logan; Barnes, Lisa L et al. (2018) Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathol 136:857-872
Tse, Kai-Hei; Cheng, Aifang; Ma, Fulin et al. (2018) DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer's disease and dementia. Alzheimers Dement 14:664-679
Schaffert, Jeff; LoBue, Christian; White, Charles L et al. (2018) Traumatic brain injury history is associated with an earlier age of dementia onset in autopsy-confirmed Alzheimer's disease. Neuropsychology 32:410-416
Davis, Jeremy J (2018) Performance validity in older adults: Observed versus predicted false positive rates in relation to number of tests administered. J Clin Exp Neuropsychol 40:1013-1021
Crum, Jana; Wilson, Jeffrey; Sabbagh, Marwan (2018) Does taking statins affect the pathological burden in autopsy-confirmed Alzheimer's dementia? Alzheimers Res Ther 10:104
Kovaleva, Mariya A; Bilsborough, Elizabeth; Griffiths, Patricia C et al. (2018) Testing Tele-Savvy: Protocol for a randomized controlled trial. Res Nurs Health 41:107-120

Showing the most recent 10 out of 443 publications