The goal of the OAIC Pilot/Exploratory Studies Core (PESC) is to develop the key information needed to select and design future definitive, original studies with a high potential to advance our understanding of underlying mechanisms of and preventive interventions for physical disability in older Americans. This goal is achieved by soliciting, fostering, selecting, and then promoting promising innovative pilot and exploratory studies that address the OAIC research theme: Integrating pathways affecting physical function for new approaches to disability prevention. The PESC manages the project review and selection process, including facilitating the independent review of the advisory panel. The Core then promotes the funded pilot/ exploratory studies by ensuring the availability of optimal infrastructure, guidance, environment, funding, expertise, and instrumentation. PESC leaders actively monitor study progress, assist in analysis and interpretation of results, and provide guidance in translating pilot data into full, high-quality, original research study proposals that will successfully compete for independent extramural funding. The PESC has been a key component in the outstanding success of the Wake Forest OAIC by promoting new, externally funded studies (n=56;total $23.8 million), generating relevant, high-impact publications (n=334;5821 SCI citations), and training junior faculty for research (n=15). The PESC is well integrated with all OAIC cores, and is particularly tightly integrated with the Research Career Development Core (RCDC). By providing funding and expertise to design and execute welldesigned, relevant pilot and exploratory studies, the PESC helps ensure junior investigators develop the needed preliminary data for successful career development and independent research applications. The PESC also seeks and guides more senior investigators, including from other disciplines, to broaden and refocus their efforts to develop novel, integrated approaches to problems relevant to the OAIC theme. A new innovation of the PESC will be the development and dissemination of a program to train and assist investigators in developing appropriate pilot project proposals. The PESC co-leaders are two well-established investigators, one in basic and one in clinical aging research, who are highly successful independently, have strategically complementary skill sets, and have exemplary records of achievement in collaborating scientifically and administratively to develop and mentor new investigators in translational research. In the first year, the OAIC Pilot/Exploratory Studies Core proposes to fund four pilot studies, comprised of both clinical and basic research studies, human and animal studies, and mechanistic and intervention studies. This broad, integrated, collaborative approach fosters multiple levels of translation between basic and clinical research in order to advance our understanding of pathways affecting physical function and development of new approaches to disability prevention.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
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Special Emphasis Panel (ZAG1-ZIJ-8)
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Wake Forest University Health Sciences
United States
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Murphy, Rachel A; Hagaman, Ashley K; Reinders, Ilse et al. (2016) Depressive Trajectories and Risk of Disability and Mortality in Older Adults: Longitudinal Findings From the Health, Aging, and Body Composition Study. J Gerontol A Biol Sci Med Sci 71:228-35
Gill, Thomas M; Pahor, Marco; Guralnik, Jack M et al. (2016) Effect of structured physical activity on prevention of serious fall injuries in adults aged 70-89: randomized clinical trial (LIFE Study). BMJ 352:i245
Beavers, Kristen M; Leng, Iris; Rapp, Stephen R et al. (2016) Effects of Longitudinal Glucose Exposure on Cognitive and Physical Function: Results from the Action for Health in Diabetes Movement and Memory Study. J Am Geriatr Soc :
Klepin, Heidi D; Tooze, Janet A; Pardee, Timothy S et al. (2016) Effect of Intensive Chemotherapy on Physical, Cognitive, and Emotional Health of Older Adults with Acute Myeloid Leukemia. J Am Geriatr Soc 64:1988-1995
Kitzman, Dalane W; Haykowsky, Mark J (2016) Vascular Dysfunction in Heart Failure with Preserved Ejection Fraction. J Card Fail 22:12-6
Marsh, Anthony P; Applegate, William B; Guralnik, Jack M et al. (2016) Hospitalizations During a Physical Activity Intervention in Older Adults at Risk of Mobility Disability: Analyses from the Lifestyle Interventions and Independence for Elders Randomized Clinical Trial. J Am Geriatr Soc 64:933-43
Kheirkhahan, Matin; Tudor-Locke, Catrine; Axtell, Robert et al. (2016) Actigraphy features for predicting mobility disability in older adults. Physiol Meas 37:1813-1833
Li, Xiaotong; Santago 2nd, Anthony C; Vidt, Meghan E et al. (2016) Analysis of effects of loading and postural demands on upper limb reaching in older adults using statistical parametric mapping. J Biomech 49:2806-2816
Hall, Michael E; Brinkley, Tina E; Chughtai, Haroon et al. (2016) Adiposity Is Associated with Gender-Specific Reductions in Left Ventricular Myocardial Perfusion during Dobutamine Stress. PLoS One 11:e0146519
Messi, María Laura; Li, Tao; Wang, Zhong-Min et al. (2016) Resistance Training Enhances Skeletal Muscle Innervation Without Modifying the Number of Satellite Cells or their Myofiber Association in Obese Older Adults. J Gerontol A Biol Sci Med Sci 71:1273-80

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