The WFU OAIC discovers and examines novel pathways that contribute to loss of physical function with age and that will identify predictors, preventive strategies, and interventions for disability. The Integrative Biology Core (IBC) works synergistically with other Cores to discover underlying biological and cell-based factors and pathways that may serve as novel targets for evaluating new therapies to prevent or reduce disability. The Core's expertise and services, its flexible and scalable administrative operation, and its emphasis on clinically relevant research offers OAIC researchers easily accessible opportunities to expand and leverage their research to include biological outcomes. In the prior cycle, this Core enabled measurement of systemic blood biomarkers;in vitro measures of skeletal muscle, adipose tissue histology, and gene and protein expression;and genetic factors. The proposed IBC will sustain this work and expand its scope to support discovery of cellular level mechanisms underlying disability. IBC leaders will integrate these basic biological models and outcomes with other physiologic and clinical data, provide and leverage resources, contribute scientific guidance and expertise, continue to develop and extend new services and cutting-edge techniques, and provide educational and training opportunities to support novel research in line with our theme of """"""""Integrating pathways affecting physical function for new approaches to disability treatment and prevention"""""""". The IBC provides our OAIC with the infrastructure of cutting-edge biological scientific expertise and methodologies required to accomplish our Core's scientific objectives, which are to;1) Advance understanding of the cellular, tissue-level, and systemic biological factors underlying aging-related changes in body composition, physical function, and onset of disability;2) Determine whether specific behavioral and pharmacological interventions will modify these biological factors to prevent or treat disability;&3) Offer a biospecimen resource, and develop new assays and Core services that will catalyze novel research using innovative methodologies to address research questions relevant to the OAIC theme. In the initial year, we will support new research in 3 pilot studies, 7 externally-funded studies, and a Research Development Project. We will also support, educate, and train research fellows and junior faculty in the methodologies and techniques used for the study of cellular, tissue-level, and systemic biological factors, and offer educational opportunities to foster translational research and communication of WFU OAIC Core-supported research findings.

Public Health Relevance

Many factors contribute to aging-related disability and loss of independence. The research supported by our integrative Biology Core focuses on identifying the biological factors that lead to aging-related changes in body composition, physical function, and onset of disability so that new therapies can be discovered and used to prevent disability and maintain independence for older adults.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
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Special Emphasis Panel (ZAG1-ZIJ-8 (J1))
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Wake Forest University Health Sciences
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Murphy, Rachel A; Hagaman, Ashley K; Reinders, Ilse et al. (2016) Depressive Trajectories and Risk of Disability and Mortality in Older Adults: Longitudinal Findings From the Health, Aging, and Body Composition Study. J Gerontol A Biol Sci Med Sci 71:228-35
Gill, Thomas M; Pahor, Marco; Guralnik, Jack M et al. (2016) Effect of structured physical activity on prevention of serious fall injuries in adults aged 70-89: randomized clinical trial (LIFE Study). BMJ 352:i245
Beavers, Kristen M; Leng, Iris; Rapp, Stephen R et al. (2016) Effects of Longitudinal Glucose Exposure on Cognitive and Physical Function: Results from the Action for Health in Diabetes Movement and Memory Study. J Am Geriatr Soc :
Klepin, Heidi D; Tooze, Janet A; Pardee, Timothy S et al. (2016) Effect of Intensive Chemotherapy on Physical, Cognitive, and Emotional Health of Older Adults with Acute Myeloid Leukemia. J Am Geriatr Soc 64:1988-1995
Kitzman, Dalane W; Haykowsky, Mark J (2016) Vascular Dysfunction in Heart Failure with Preserved Ejection Fraction. J Card Fail 22:12-6
Marsh, Anthony P; Applegate, William B; Guralnik, Jack M et al. (2016) Hospitalizations During a Physical Activity Intervention in Older Adults at Risk of Mobility Disability: Analyses from the Lifestyle Interventions and Independence for Elders Randomized Clinical Trial. J Am Geriatr Soc 64:933-43
Kheirkhahan, Matin; Tudor-Locke, Catrine; Axtell, Robert et al. (2016) Actigraphy features for predicting mobility disability in older adults. Physiol Meas 37:1813-1833
Li, Xiaotong; Santago 2nd, Anthony C; Vidt, Meghan E et al. (2016) Analysis of effects of loading and postural demands on upper limb reaching in older adults using statistical parametric mapping. J Biomech 49:2806-2816
Hall, Michael E; Brinkley, Tina E; Chughtai, Haroon et al. (2016) Adiposity Is Associated with Gender-Specific Reductions in Left Ventricular Myocardial Perfusion during Dobutamine Stress. PLoS One 11:e0146519
Messi, María Laura; Li, Tao; Wang, Zhong-Min et al. (2016) Resistance Training Enhances Skeletal Muscle Innervation Without Modifying the Number of Satellite Cells or their Myofiber Association in Obese Older Adults. J Gerontol A Biol Sci Med Sci 71:1273-80

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