The Wake Forest University Claude D. Pepper Older Americans Independence Center (WFU OAIC) has cultivated expertise to develop and test interventions to improve physical function and prevent disability in a translational approach that integrates medicine, behavioral and cognitive science, biostatistics, genomics, basic science, state-of-the-art imaging modalities, and clinical and population approaches. Based on its theme, integrating pathways affecting physical function for new approaches to disability treatment and prevention, the WFU OAIC will pursue four programmatic aims: 1. Discover new common pathways contributing to age-related declines in physical function and disability; 2. Develop, evaluate and refine strategies for disability treatment and prevention; 3. Translate proven strategies beyond the traditional academic research environment;and 4. Train the next generation of researchers leaders focused on disability treatment and prevention. The infrastructure to pursue these aims will be provided by 4 highly productive and interactive research support cores: the Clinical Research Core;Biostatistics and Research Information Systems Core;Integrative Biology Core;and Bioimaging Resource Core. Under continuing and dedicated leadership of Drs. Kritchevsky and Kitzman, the Leadership and Administrative Core will coordinate these research core activities with those of the Research Career Development and Pilot and Exploratory Studies Cores. The WFU OAIC will use its core structure and highly integrated approach to: 1) discover and incorporate new pathways important to functional decline, including brain-mediated ones, into a multi-factorial model that supports intervention development and translational, multi-disciplinary collaborative research; 2) evaluate interventions targeting obesity, one of the most important threats to continued improvement of age-related disability rates; 3) increase the translation of proven approaches into clinical and community settings; 4) train the next generation of research leaders focused on disability treatment and prevention;and 5) refine effective strategies to increase research efficiency in response to diminished resources for aging research. The infrastructure to pursue these aims will be provided by 4 highly productive and interactive research support cores: the Clinical Research Core;Biostatistics and Research Information Systems Core;Integrative Biology Core;and Biolmaging Resource Core. Under continuing and dedicated leadership of Drs. Kritchevsky and Kitzman, the Leadership and Administrative Core will coordinate these research core activities with those of the Research Career Development and Pilot and Exploratory Studies Cores. The WFU OAIC will use its core structure and highly integrated approach to: 1) discover and incorporate new pathways important to functional decline, including brain-mediated ones, into a multi-factorial model that supports intervention development and translational, multi-disciplinary collaborative research;2) evaluate interventions targeting obesity, one of the most important threats to continued improvement of age-related disability rates;3) increase the translation of proven approaches into clinical and community settings;4) train the next generation of research leaders focused on disability treatment and prevention;and 5) refine effective strategies to increase research efficiency in response to diminished resources for aging research.

Public Health Relevance

In anticipation of the needs of the growing number of older adults, the WFU OAIC will identify and evaluate novel strategies to prevent physical disability and return disabled older adults to independence using its highly integrated research and training infrastructure.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG021332-12
Application #
8698687
Study Section
Special Emphasis Panel (ZAG1)
Program Officer
Eldadah, Basil A
Project Start
2002-09-30
Project End
2018-06-30
Budget Start
2014-08-15
Budget End
2015-06-30
Support Year
12
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
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Li, Xiaotong; Santago 2nd, Anthony C; Vidt, Meghan E et al. (2016) Analysis of effects of loading and postural demands on upper limb reaching in older adults using statistical parametric mapping. J Biomech 49:2806-2816
Hall, Michael E; Brinkley, Tina E; Chughtai, Haroon et al. (2016) Adiposity Is Associated with Gender-Specific Reductions in Left Ventricular Myocardial Perfusion during Dobutamine Stress. PLoS One 11:e0146519
Messi, María Laura; Li, Tao; Wang, Zhong-Min et al. (2016) Resistance Training Enhances Skeletal Muscle Innervation Without Modifying the Number of Satellite Cells or their Myofiber Association in Obese Older Adults. J Gerontol A Biol Sci Med Sci 71:1273-80

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