The Wake Forest University Claude D. Pepper Older Americans Independence Center (WFU OAIC) has cultivated expertise to develop and test interventions to improve physical function and prevent disability in a translational approach that integrates medicine, behavioral and cognitive science, biostatistics, genomics, basic science, state-of-the-art imaging modalities, and clinical and population approaches. Based on its theme, integrating pathways affecting physical function for new approaches to disability treatment and prevention, the WFU OAIC will pursue four programmatic aims: 1. Discover new common pathways contributing to age-related declines in physical function and disability; 2. Develop, evaluate and refine strategies for disability treatment and prevention; 3. Translate proven strategies beyond the traditional academic research environment;and 4. Train the next generation of researchers leaders focused on disability treatment and prevention. The infrastructure to pursue these aims will be provided by 4 highly productive and interactive research support cores: the Clinical Research Core;Biostatistics and Research Information Systems Core;Integrative Biology Core;and Bioimaging Resource Core. Under continuing and dedicated leadership of Drs. Kritchevsky and Kitzman, the Leadership and Administrative Core will coordinate these research core activities with those of the Research Career Development and Pilot and Exploratory Studies Cores. The WFU OAIC will use its core structure and highly integrated approach to: 1) discover and incorporate new pathways important to functional decline, including brain-mediated ones, into a multi-factorial model that supports intervention development and translational, multi-disciplinary collaborative research; 2) evaluate interventions targeting obesity, one of the most important threats to continued improvement of age-related disability rates; 3) increase the translation of proven approaches into clinical and community settings; 4) train the next generation of research leaders focused on disability treatment and prevention;and 5) refine effective strategies to increase research efficiency in response to diminished resources for aging research. The infrastructure to pursue these aims will be provided by 4 highly productive and interactive research support cores: the Clinical Research Core;Biostatistics and Research Information Systems Core;Integrative Biology Core;and Biolmaging Resource Core. Under continuing and dedicated leadership of Drs. Kritchevsky and Kitzman, the Leadership and Administrative Core will coordinate these research core activities with those of the Research Career Development and Pilot and Exploratory Studies Cores. The WFU OAIC will use its core structure and highly integrated approach to: 1) discover and incorporate new pathways important to functional decline, including brain-mediated ones, into a multi-factorial model that supports intervention development and translational, multi-disciplinary collaborative research;2) evaluate interventions targeting obesity, one of the most important threats to continued improvement of age-related disability rates;3) increase the translation of proven approaches into clinical and community settings;4) train the next generation of research leaders focused on disability treatment and prevention;and 5) refine effective strategies to increase research efficiency in response to diminished resources for aging research.

Public Health Relevance

In anticipation of the needs of the growing number of older adults, the WFU OAIC will identify and evaluate novel strategies to prevent physical disability and return disabled older adults to independence using its highly integrated research and training infrastructure.

Agency
National Institute of Health (NIH)
Type
Center Core Grants (P30)
Project #
3P30AG021332-12S1
Application #
8914776
Study Section
Special Emphasis Panel (ZAG1)
Program Officer
Eldadah, Basil A
Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
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Klepin, Heidi D; Geiger, Ann M; Bandos, Hanna et al. (2014) Cognitive factors associated with adherence to oral antiestrogen therapy: results from the cognition in the study of tamoxifen and raloxifene (Co-STAR) study. Cancer Prev Res (Phila) 7:161-8
Groban, Leanne; Kitzman, Dalane W; Register, Thomas C et al. (2014) Effect of depression and sertraline treatment on cardiac function in female nonhuman primates. Psychosom Med 76:137-46
Grosicki, Gregory J; Miller, Michael E; Marsh, Anthony P (2014) Resistance exercise performance variability at submaximal intensities in older and younger adults. Clin Interv Aging 9:209-18

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