This proposal seeks renewal of an Older Americans Independence Center at the Johns Hopkins Medical Institutions. The focus of this Center is to promote independence for frail older adults through the development of interventions to prevent or ameliorate frailty and the many serious, adverse outcomes that frail older adults are at risk for. To accomplish this, a multidisciplinary group of senior and junior investigators, in multiple departments and Programs at this institution, propose to continue and enhance, through this OAIC, 1. the Leadership Council that will stimulate, lead and sustain a University-wide interdisciplinary research program investigating frailty, its etiology and opportunities for treatment;2. the infrastructure and methodologic development essential to creating the next generations of research on frailty in older adults;3. support for the career development of outstanding junior faculty committed to research careers that will lead to treatments for frailty and its prevention;and 4. to cultivate and support pilot studies that will provide the basis for investigator-initiated and funded research towards interventions on frailty. The OAIC would provide the support critical to complement and harness the substantial strengths already at this institution into a unified and potent effort directed at developing interventions for frailty. It is designed to ensure multidisciplinary translation between basic, mechanistic and clinical/population-based research, and of each into development of treatments for frailty. This organized infrastructure and scientific leadership will serve as a source of advice and collaborations to investigators at our own institution and at other institutions in the area of research on frailty in aging. The OAIC will be administratively led by, and housed in, the Johns Hopkins Center on Aging and Health, with strong leadership and participation by all of the institutional programs committed to aging research;it will also seek to expand to incorporate leaders and investigators not previously involved in research on frailty but who have made a commitment to this work through the planning process for this proposal. This OAIC has strong institutional commitment, based on the priority at the Medical Institutions for the unification and strengthening of aging research and spotlighting its importance for the entire institution. Overall, it is designed to spearhead a new depth and intensity of research to improve outcomes and promote independence for frail, older adults.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8 (J1))
Program Officer
Eldadah, Basil A
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Johns Hopkins University
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Walston, Jeremy; Robinson, Thomas N; Zieman, Susan et al. (2017) Integrating Frailty Research into the Medical Specialties-Report from a U13 Conference. J Am Geriatr Soc 65:2134-2139
Weiss, Kilian; Schär, Michael; Panjrath, Gurusher S et al. (2017) Fatigability, Exercise Intolerance, and Abnormal Skeletal Muscle Energetics in Heart Failure. Circ Heart Fail 10:
McAdams-DeMarco, Mara A; King, Elizabeth A; Luo, Xun et al. (2017) Frailty, Length of Stay, and Mortality in Kidney Transplant Recipients: A National Registry and Prospective Cohort Study. Ann Surg 266:1084-1090
Buta, Brian; Choudhury, Parichoy Pal; Xue, Qian-Li et al. (2017) The Association of Vitamin D Deficiency and Incident Frailty in Older Women: The Role of Cardiometabolic Diseases. J Am Geriatr Soc 65:619-624
Graham, Antonio; Brown 4th, Charles H (2017) Frailty, Aging, and Cardiovascular Surgery. Anesth Analg 124:1053-1060
McAdams-DeMarco, Mara A; Ying, Hao; Olorundare, Israel et al. (2017) Individual Frailty Components and Mortality in Kidney Transplant Recipients. Transplantation 101:2126-2132
Tan, Jingwen; Bae, Sunjae; Segal, Jodi B et al. (2017) Warfarin Use And the Risk Of Stroke, Bleeding, And Mortality In Older Adults On Dialysis With Incident Atrial Fibrillation. Nephrology (Carlton) :
Piggott, Damani A; Muzaale, Abimereki D; Varadhan, Ravi et al. (2017) Frailty and Cause-Specific Hospitalization Among Persons Aging With HIV Infection and Injection Drug Use. J Gerontol A Biol Sci Med Sci 72:389-394
Kucharska-Newton, Anna M; Palta, Priya; Burgard, Sheila et al. (2017) Operationalizing Frailty in the Atherosclerosis Risk in Communities Study Cohort. J Gerontol A Biol Sci Med Sci 72:382-388
Wyrobek, J; LaFlam, A; Max, L et al. (2017) Association of intraoperative changes in brain-derived neurotrophic factor and postoperative delirium in older adults. Br J Anaesth 119:324-332

Showing the most recent 10 out of 220 publications