This proposal seeks renewal of an Older Americans Independence Center at the Johns Hopkins Medical Institutions. The focus of this Center is to promote independence for frail older adults through the development of interventions to prevent or ameliorate frailty and the many serious, adverse outcomes that frail older adults are at risk for. To accomplish this, a multidisciplinary group of senior and junior investigators, in multiple departments and Programs at this institution, propose to continue and enhance, through this OAIC, 1. the Leadership Council that will stimulate, lead and sustain a University-wide interdisciplinary research program investigating frailty, its etiology and opportunities for treatment;2. the infrastructure and methodologic development essential to creating the next generations of research on frailty in older adults;3. support for the career development of outstanding junior faculty committed to research careers that will lead to treatments for frailty and its prevention;and 4. to cultivate and support pilot studies that will provide the basis for investigator-initiated and funded research towards interventions on frailty. The OAIC would provide the support critical to complement and harness the substantial strengths already at this institution into a unified and potent effort directed at developing interventions for frailty. It is designed to ensure multidisciplinary translation between basic, mechanistic and clinical/population-based research, and of each into development of treatments for frailty. This organized infrastructure and scientific leadership will serve as a source of advice and collaborations to investigators at our own institution and at other institutions in the area of research on frailty in aging. The OAIC will be administratively led by, and housed in, the Johns Hopkins Center on Aging and Health, with strong leadership and participation by all of the institutional programs committed to aging research;it will also seek to expand to incorporate leaders and investigators not previously involved in research on frailty but who have made a commitment to this work through the planning process for this proposal. This OAIC has strong institutional commitment, based on the priority at the Medical Institutions for the unification and strengthening of aging research and spotlighting its importance for the entire institution. Overall, it is designed to spearhead a new depth and intensity of research to improve outcomes and promote independence for frail, older adults.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
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Study Section
Special Emphasis Panel (ZAG1-ZIJ-8 (J1))
Program Officer
Eldadah, Basil A
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Johns Hopkins University
Internal Medicine/Medicine
Schools of Medicine
United States
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Varma, Vijay R; Carlson, Michelle C; Parisi, Jeanine M et al. (2015) Experience Corps Baltimore: Exploring the Stressors and Rewards of High-intensity Civic Engagement. Gerontologist 55:1038-49
Varma, Vijay R; Chuang, Yi-Fang; Harris, Gregory C et al. (2015) Low-intensity daily walking activity is associated with hippocampal volume in older adults. Hippocampus 25:605-15
McAdams-DeMarco, Mara A; Law, Andrew; Tan, Jingwen et al. (2015) Frailty, mycophenolate reduction, and graft loss in kidney transplant recipients. Transplantation 99:805-10
Corriere, Mark D; Minang, Laura B; Sisson, Stephen D et al. (2014) The use of clinical guidelines highlights ongoing educational gaps in physicians' knowledge and decision making related to diabetes. BMC Med Educ 14:186
Salter, Megan L; McAdams-Demarco, Mara A; Law, Andrew et al. (2014) Age and sex disparities in discussions about kidney transplantation in adults undergoing dialysis. J Am Geriatr Soc 62:843-9
Chuang, Yi-Fang; Eldreth, Dana; Erickson, Kirk I et al. (2014) Cardiovascular risks and brain function: a functional magnetic resonance imaging study of executive function in older adults. Neurobiol Aging 35:1396-403
McAdams-Demarco, M A; Grams, M E; King, E et al. (2014) Sequelae of early hospital readmission after kidney transplantation. Am J Transplant 14:397-403
Kalyani, Rita R; Tra, Y; Egan, J M et al. (2014) Hyperglycemia is associated with relatively lower lean body mass in older adults. J Nutr Health Aging 18:737-43
Weinreich, Heather M; Agrawal, Yuri (2014) The link between allergy and Menière's disease. Curr Opin Otolaryngol Head Neck Surg 22:227-30
Tan, Erwin J; McGill, Sylvia; Tanner, Elizabeth K et al. (2014) The evolution of an academic-community partnership in the design, implementation, and evaluation of experience corpsýý Baltimore city: a courtship model. Gerontologist 54:314-21

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