This is a renewal application for the Johns Hopkins University Older Americans Independence Center(OAIC). Investigators in this center seek to promote independence in older adults through the study of the etiologies of frailty and through the translation of this knowledge into the development of novel, frailty focused interventions.
The specific aims of this proposal are: 1) to stimulate and develop effective frailty focused interdisciplinary research programs 2) to translate the frailty-focused knowledge generated in this OAIC into targeted prevention and treatment strategies that help older adults maintain independence;3) to provide focused and accessible frailty-related training and mentorship to junior investigators interested in developing careers focused on maintaining independence in older adults;4) to provide the highest quality interdisciplinary expertise and infrastructure in biostatistical, biological, and clinical research that is relevant to frailty research to OAIC supported investigators;5) to support the development of innovative methodologies, research strategies and technologies essential to the study of frailty;and 6) to attract outstanding investigators and trainees to frailty research from across the Johns Hopkins University and to promote visibility of their science locally and nationally. Leadership, career development, and pilot study cores will provide scientific vision, training, and study support mechanisms. Highly integrated biostatistics, biological mechanisms, and a clinical translational and recruitment cores, along with the additional institutional research resources and support, will provide supported investigators with the interdisciplinary expertise, training, mentorship, and service necessary to stimulate outstanding frailty-focused basic, clinical and translational research programs. This OAIC and its leadership has strong institutional commitment for the development of these programs, and for the strengthening of aging research for the entire institution. This Infrastructure and scientific leadership will serve as a source of frailty-focuse scientific vision, expertise, training, research support, collaboration, and translation for investigators at Johns Hopkins, other OAICs and at other academic institutions in the area of research on frailty in aging.

Public Health Relevance

Frailty is an age-related syndrome of multisystemic decline which confers vulnerability to many other adverse outcomes including loss of independence. This OAIC is designed to foster high quality research which will identify etiologies of frailty and translate these findings into clinical studies that will improve function and health for millions o older adults.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
2P30AG021334-11
Application #
8470879
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8 (J1))
Program Officer
Eldadah, Basil A
Project Start
2003-06-01
Project End
2018-06-30
Budget Start
2013-07-15
Budget End
2014-06-30
Support Year
11
Fiscal Year
2013
Total Cost
$1,123,788
Indirect Cost
$430,092
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Ko, Fred; Abadir, Peter; Marx, Ruth et al. (2016) Impaired mitochondrial degradation by autophagy in the skeletal muscle of the aged female interleukin 10 null mouse. Exp Gerontol 73:23-7
Sun, Daniel Q; Huang, Jin; Varadhan, Ravi et al. (2016) Race and fall risk: data from the National Health and Aging Trends Study (NHATS). Age Ageing 45:120-7
Xue, Qian-Li; Tian, Jing; Fried, Linda P et al. (2016) Physical Frailty Assessment in Older Women: Can Simplification Be Achieved Without Loss of Syndrome Measurement Validity? Am J Epidemiol 183:1037-44
Abadir, Peter; Jain, Alka; Powell, Laura et al. (2016) Discovery and Validation of Agonistic Angiotensin Receptor Autoantibodies as Biomarkers of Adverse Outcomes. Circulation :
Gross, Alden L; Xue, Qian-Li; Bandeen-Roche, Karen et al. (2016) Declines and Impairment in Executive Function Predict Onset of Physical Frailty. J Gerontol A Biol Sci Med Sci 71:1624-1630
Cohen, Harvey J; Walston, Jeremy D; Rao, Sunil V et al. (2016) Renal Toxicity Associated with Salsalate in Elderly Adults with Anemia. J Am Geriatr Soc 64:898-9
Cooper, Zara; Rogers Jr, Selwyn O; Ngo, Long et al. (2016) Comparison of Frailty Measures as Predictors of Outcomes After Orthopedic Surgery. J Am Geriatr Soc 64:2464-2471
Tan, Jingwen; Liu, Shuiqing; Segal, Jodi B et al. (2016) Warfarin use and stroke, bleeding and mortality risk in patients with end stage renal disease and atrial fibrillation: a systematic review and meta-analysis. BMC Nephrol 17:157
Sweeney, Elizabeth M; Shinohara, Russell T; Dewey, Blake E et al. (2016) Relating multi-sequence longitudinal intensity profiles and clinical covariates in incident multiple sclerosis lesions. Neuroimage Clin 10:1-17
Semenov, Yevgeniy R; Bigelow, Robin T; Xue, Qian-Li et al. (2016) Association Between Vestibular and Cognitive Function in U.S. Adults: Data From the National Health and Nutrition Examination Survey. J Gerontol A Biol Sci Med Sci 71:243-50

Showing the most recent 10 out of 194 publications