The OAIC Biostatistics Core dedicates critically needed resources toward the quantitative challenges of research on frailty. Collaborating in OAIC leadership, and working closely with OAlC Resource, Research Career Development Core (RCDC) and Pilot and Experimental Studies Core (PESC), it aims to: (1) mentor junior scholars supported by our RCDC, PESC and broader OAIC, with the goals of optimizing their: access to data analytic expertise and support;usage of modern database and analytic resources;training in quantitative methods needed to perform high quality research and effectiveness of collaboration with statistical colleagues;(2) provide resources in data infrastructure and emerging computing technologies essential to discovery on frailty, and not possible absent an OAIC or its equivalent;(3) stimulate and advance research on frailty at our institution, by: (a) providing data analytic and management expertise and material support for research on frailty, and (b) developing new methodologies for data analysis needed to conduct basic research on frailty and translate it into clinical practice;and (4) partner with our fellow OAIC Cores, the scholarly community on aging at Johns Hopkins, and with fellow OAICs to advance scholarship on frailty and aging, its translation into effective prevention and intervention strategies, and heighten its visibility. The Core benefits from leadership in these areas that has been long-standing, substantial and wide-reaching. Its situation within this OAIC allows it to provide consultation and collaboration to junior researchers lacking resources. Regarding new methodologies: Research in the coming cycle would be directed to increasing the proof of principle for the hypothesis that dysregulation in multiple physiological systems underpins frailty. By efforts along all these lines, this Core is essential to the success of this OAIC in answering a next generation of questions on frailty, and achieving findings'translation toward increased independence of older persons.

Public Health Relevance

Frailty is a frequent adverse outcome of aging which confers vulnerability to many other adverse outcomes including loss of independence. As a syndrome with a complex etiology, its study poses high data analytic challenges, and research to determine its etiology and methods to ameliorate it require advanced expertise and support. Thus this Core's collaboration in this OAIC is crucial to efforts to improve health and quality of life for millions in our expanding older population

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
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Special Emphasis Panel (ZAG1-ZIJ-8 (J1))
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Varma, Vijay R; Carlson, Michelle C; Parisi, Jeanine M et al. (2015) Experience Corps Baltimore: Exploring the Stressors and Rewards of High-intensity Civic Engagement. Gerontologist 55:1038-49
Varma, Vijay R; Chuang, Yi-Fang; Harris, Gregory C et al. (2015) Low-intensity daily walking activity is associated with hippocampal volume in older adults. Hippocampus 25:605-15
McAdams-DeMarco, Mara A; Law, Andrew; Tan, Jingwen et al. (2015) Frailty, mycophenolate reduction, and graft loss in kidney transplant recipients. Transplantation 99:805-10
Corriere, Mark D; Minang, Laura B; Sisson, Stephen D et al. (2014) The use of clinical guidelines highlights ongoing educational gaps in physicians' knowledge and decision making related to diabetes. BMC Med Educ 14:186
Salter, Megan L; McAdams-Demarco, Mara A; Law, Andrew et al. (2014) Age and sex disparities in discussions about kidney transplantation in adults undergoing dialysis. J Am Geriatr Soc 62:843-9
Chuang, Yi-Fang; Eldreth, Dana; Erickson, Kirk I et al. (2014) Cardiovascular risks and brain function: a functional magnetic resonance imaging study of executive function in older adults. Neurobiol Aging 35:1396-403
McAdams-Demarco, M A; Grams, M E; King, E et al. (2014) Sequelae of early hospital readmission after kidney transplantation. Am J Transplant 14:397-403
Kalyani, Rita R; Tra, Y; Egan, J M et al. (2014) Hyperglycemia is associated with relatively lower lean body mass in older adults. J Nutr Health Aging 18:737-43
Weinreich, Heather M; Agrawal, Yuri (2014) The link between allergy and Menière's disease. Curr Opin Otolaryngol Head Neck Surg 22:227-30
Tan, Erwin J; McGill, Sylvia; Tanner, Elizabeth K et al. (2014) The evolution of an academic-community partnership in the design, implementation, and evaluation of experience corpsýý Baltimore city: a courtship model. Gerontologist 54:314-21

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