This is a renewal application for the Johns Hopkins University Older Americans Independence Center(OAIC). Investigators in this center seek to promote independence in older adults through the study of the etiologies of frailty and through the translation of this knowledge into the development of novel, frailty focused interventions.
The specific aims of this proposal are: 1) to stimulate and develop effective frailty focused interdisciplinary research programs 2) to translate the frailty-focused knowledge generated in this OAIC into targeted prevention and treatment strategies that help older adults maintain independence;3) to provide focused and accessible frailty-related training and mentorship to junior investigators interested in developing careers focused on maintaining independence in older adults;4) to provide the highest quality interdisciplinary expertise and infrastructure in biostatistical, biological, and clinical research that is relevant to frailty research to OAIC supported investigators;5) to support the development of innovative methodologies, research strategies and technologies essential to the study of frailty;and 6) to attract outstanding investigators and trainees to frailty research from across the Johns Hopkins University and to promote visibility of their science locally and nationally. Leadership, career development, and pilot study cores will provide scientific vision, training, and study support mechanisms. Highly integrated biostatistics, biological mechanisms, and a clinical translational and recruitment cores, along with the additional institutional research resources and support, will provide supported investigators with the interdisciplinary expertise, training, mentorship, and service necessary to stimulate outstanding frailty-focused basic, clinical and translational research programs. This OAIC and its leadership has strong institutional commitment for the development of these programs, and for the strengthening of aging research for the entire institution. This Infrastructure and scientific leadership will serve as a source of frailty-focuse scientific vision, expertise, training, research support, collaboration, and translation for investigators at Johns Hopkins, other OAICs and at other academic institutions in the area of research on frailty in aging.

Public Health Relevance

Frailty is an age-related syndrome of multisystemic decline which confers vulnerability to many other adverse outcomes including loss of independence. This OAIC is designed to foster high quality research which will identify etiologies of frailty and translate these findings into clinical studies that will improve function and health for millions o older adults.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG021334-12
Application #
8700263
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8 (J1))
Program Officer
Eldadah, Basil A
Project Start
2003-06-01
Project End
2018-06-30
Budget Start
2014-08-01
Budget End
2015-06-30
Support Year
12
Fiscal Year
2014
Total Cost
$1,209,254
Indirect Cost
$462,801
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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Weiss, Kilian; Schär, Michael; Panjrath, Gurusher S et al. (2017) Fatigability, Exercise Intolerance, and Abnormal Skeletal Muscle Energetics in Heart Failure. Circ Heart Fail 10:
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Buta, Brian; Choudhury, Parichoy Pal; Xue, Qian-Li et al. (2017) The Association of Vitamin D Deficiency and Incident Frailty in Older Women: The Role of Cardiometabolic Diseases. J Am Geriatr Soc 65:619-624
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McAdams-DeMarco, Mara A; Ying, Hao; Olorundare, Israel et al. (2017) Individual Frailty Components and Mortality in Kidney Transplant Recipients. Transplantation 101:2126-2132
Tan, Jingwen; Bae, Sunjae; Segal, Jodi B et al. (2017) Warfarin Use And the Risk Of Stroke, Bleeding, And Mortality In Older Adults On Dialysis With Incident Atrial Fibrillation. Nephrology (Carlton) :
Piggott, Damani A; Muzaale, Abimereki D; Varadhan, Ravi et al. (2017) Frailty and Cause-Specific Hospitalization Among Persons Aging With HIV Infection and Injection Drug Use. J Gerontol A Biol Sci Med Sci 72:389-394
Kucharska-Newton, Anna M; Palta, Priya; Burgard, Sheila et al. (2017) Operationalizing Frailty in the Atherosclerosis Risk in Communities Study Cohort. J Gerontol A Biol Sci Med Sci 72:382-388
Wyrobek, J; LaFlam, A; Max, L et al. (2017) Association of intraoperative changes in brain-derived neurotrophic factor and postoperative delirium in older adults. Br J Anaesth 119:324-332

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