The Biostatistics Core (BC) provides state of the art biostatistical expertise for the Yale OIAC. The specificfunctions of the core are to ensure the proper design and analysis of studies of multifactorial geriatric healthconditions, to develop and apply new statistical methodology, and to develop and institute education andtraining programs. The BC will provide the following services to the Yale OAIC: collaborate with investigatorsin the preparation of OAIC grants to ensure proper research designs are being used, consult with junior andsenior investigators about study design and analysis issues, serve as a resource about design and statisticalissues, perform statistical analyses, collaborate with investigators on manuscript preparation, providementorship and education and training programs for junior clinical investigators, biostatisticians andepidemiologists, and develop or apply new methodology. The BC staff has a broad range of statisticalexpertise that will enable them to contribute to the mission of the Yale OAIC. This expertise includes:experimental design (randomized clinical trials, epidemiological studies, reliability studies, clustered designs,and multi-component interventions for multifactorial geriatric health conditions), regression and longitudinalmethods (multiple linear, binomial and logistic regression; hierarchical linear models; generalized estimatingequations; and generalized linear and non linear mixed models), survival models (proportional hazardsmodels with single and recurrent events, multistate models), imputation, Bayesian methods, spatio-temporalmodeling, stochastic models and computational biology. The BC is proposing a development project in theemerging field of computational biology with the overarching aim to establish a collaborative team ofresearchers to develop new systems biology approaches to aging research. A future direction of the Core isto establish a program for gerontologic biostatistics to train the next generation of biostatisticians in geriatricresearch.
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