The Yale OAIC is focused on the investigation of multifactorial geriatric health conditions, with the ultimate goal of developing, testing, and disseminating new strategies to preserve or restore the independence of older persons. An Operations Core for the OAIC is essential for the recruitment and retention of diverse populations of older persons into research studies, the building of relationships with community leaders, and the seamless integration of Field personnel tasks with Data Management/Informatics operations. During the past decade, separate Field and Data Management/Informatics (DMI) Coreis existed with a history of major accomplishments. We propose a more efficient structure with the merger of the Field and DMI Cores into a single Operations Core. This streamlined organization, which was endorsed by our External Advisory Committee, optimizes resources, increases efficiency and implementation of clinical and translational research, and facilitates integration of our data collection and data management efforts. The overall goal ofthe Yale OAIC Operations Core (OC) is to provide operational methods, staff, resources, and expertise necessary to ensure the efficient and successful completion ofthe full range of research projects (e.g., observational, interventional, basic/translational) focused on multifactorial geriatric health conditions. As a result, the OC will enhance the scientific productivity of OAIC research and facilitate its overall objectives. Collaborating with all Yale OAIC Cores, the specific aims to achieve its goal include:
AIM 1) Provide personnel for recruitment and retention of diverse research participants, and comprehensive data management systems, to support OAIC External Projects. Related Sub Aims include:
Sub Aim 1. a. Provide consulting support for operational aspects of proposal preparation;
Sub Aim 1 . b. Provide training of investigators and study staff regarding operational tasks;
Sub Aim 1 . c. Develop, test, and implement new OC methods.
AIM 2) Collaborate with RCDC, PESC, and Biostatistics Cores to facilitate coordinated strategies to develop, implement, and monitor the conduct of Yale OAlC-related studies.
AIM 3) Provide support for the design and conduct of a novel OC Development Project, "Adverse Event Monitoring and Reporting among Older Adults Participating in Multifactorial Intervention Trials" This Development Project relates to the integrated objectives ofthe OC and the overall mission ofthe Yale OAIC.

Public Health Relevance

Operational activities and innovations related to recruitment and retention, data collection and data management are critical to the conduct of research that addresses the multifactorial nature of geriatric health conditions. An integrated Operations Core ofthe Yale OAIC will facilitate the development, testing and implementation of innovative interventions to maintain and restore independence in older persons.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
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Special Emphasis Panel (ZAG1-ZIJ-8 (J1))
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Yale University
New Haven
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Mohanty, Subhasis; Joshi, Samit R; Ueda, Ikuyo et al. (2015) Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults. J Infect Dis 211:1174-84
Hartaigh, Bríain ó; Allore, Heather G; Trentalange, Mark et al. (2015) Elevations in time-varying resting heart rate predict subsequent all-cause mortality in older adults. Eur J Prev Cardiol 22:527-34
Erekson, Elisabeth A; Ciarleglio, Maria M; Hanissian, Paul D et al. (2015) Functional disability and compromised mobility among older women with urinary incontinence. Female Pelvic Med Reconstr Surg 21:170-5
Erekson, Elisabeth A; Ciarleglio, Maria M; Hanissian, Paul D et al. (2015) Functional disability among older women with fecal incontinence. Am J Obstet Gynecol 212:327.e1-7
Xu, Xiao; Liang, Jersey; Bennett, Joan M et al. (2015) Socioeconomic stratification and multidimensional health trajectories: evidence of convergence in later old age. J Gerontol B Psychol Sci Soc Sci 70:661-71
Bradley, Elizabeth H; Sipsma, Heather; Brewster, Amanda L et al. (2014) Strategies to reduce hospital 30-day risk-standardized mortality rates for patients with acute myocardial infarction: a cross-sectional and longitudinal survey. BMC Cardiovasc Disord 14:126
Lin, Haiqun; Han, Ling; Peduzzi, Peter N et al. (2014) A dynamic trajectory class model for intensive longitudinal categorical outcome. Stat Med 33:2645-64
Dodson, John A; Geda, Mary; Krumholz, Harlan M et al. (2014) Design and rationale of the comprehensive evaluation of risk factors in older patients with AMI (SILVER-AMI) study. BMC Health Serv Res 14:506
Greysen, S Ryan; Hoi-Cheung, Doug; Garcia, Veronica et al. (2014) "Missing pieces"--functional, social, and environmental barriers to recovery for vulnerable older adults transitioning from hospital to home. J Am Geriatr Soc 62:1556-61
Yao, Yi; Liu, Rebecca; Shin, Min Sun et al. (2014) CyTOF supports efficient detection of immune cell subsets from small samples. J Immunol Methods 415:1-5

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