The goal of the Pilot and Exploratory Studies Core (PESC) is to provide support for studies that will develop and test new research ideas of high relevance to the Center's overall theme, the predictors and modulators of the aging phenotype and the ways in which genetic, environmental, and social factors influence late life disease through effects on the aging process. The PESC will thus fund pilot research studies over a wide range of disciplines, ranging from basic genetics and physiology through behavioral and health services research. Each submitted proposal will first receive an evaluation for scientific merit by at least two external reviewers, and then be further evaluated by OAIC leaders for its relevance to Center objectives. The Pepper Center's former Research Development Core (REIC) has made 61 pilot grant awards since its inception in 1989, mostly to junior faculty members, many of whom have now established themselves as productive independent researchers in geriatric medicine and cognate disciplines. Four projects have been selected for funding in the 2004 - 2005 academic year, including studies of (a) the genetics of bone chemistry and fragility;(b) a new system for investigation of insulin sensitivity using muscle explants;(c) factors modifying risk of falls in frail and healthy elderly subjects;and (d) the influences of gender and ethnic group on trajectories of alcohol consumption. The PESC will be directed by Dr. Richard Miller, who has served as director of the OAIC's RDC since 1993, and will be co-directed by Dr. Jeffrey Halter. Drs. Miller and Halter will work closely with the Directors of the RCDC to assist RCDC junior faculty as they develop plans for competitive Pilot Grant applications for PESC consideration.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG024824-09
Application #
8380718
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8)
Project Start
Project End
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
9
Fiscal Year
2012
Total Cost
$187,200
Indirect Cost
$66,035
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Botoseneanu, Anda; Chen, Haiying; Ambrosius, Walter T et al. (2017) Effect of Metabolic Syndrome on the Mobility Benefit of a Structured Physical Activity Intervention-The Lifestyle Interventions and Independence for Elders Randomized Clinical Trial. J Am Geriatr Soc 65:1244-1250
Owens, Sherry L; Hunte, Haslyn E R; Sterkel, Amanda et al. (2017) Association Between Discrimination and Objective and Subjective Sleep Measures in the Midlife in the United States Study Adult Sample. Psychosom Med 79:469-478
Kotagal, Vikas; Bohnen, Nicolaas I; Müller, Martijn L T M et al. (2017) Cerebral Amyloid Burden and Hoehn and Yahr Stage 3 Scoring in Parkinson Disease. J Parkinsons Dis 7:143-147
Mau, Theresa; Yung, Raymond (2017) Adipose tissue inflammation in aging. Exp Gerontol :
Garratt, Michael; Bower, Brian; Garcia, Gonzalo G et al. (2017) Sex differences in lifespan extension with acarbose and 17-? estradiol: gonadal hormones underlie male-specific improvements in glucose tolerance and mTORC2 signaling. Aging Cell 16:1256-1266
Julius, Annabelle; Desai, Anjali; Yung, Raymond L (2017) Recombinant human erythropoietin stimulates melanoma tumor growth through activation of initiation factor eIF4E. Oncotarget 8:30317-30327
Ridder, A; Müller, M L T M; Kotagal, V et al. (2017) Impaired contrast sensitivity is associated with more severe cognitive impairment in Parkinson disease. Parkinsonism Relat Disord 34:15-19
Berkowitz, Bruce A; Miller, Richard A; Roberts, Robin (2017) Genetically heterogeneous mice show age-related vision deficits not related to increased rod cell L-type calcium channel function in vivo. Neurobiol Aging 49:198-203
Makris, Una E; Misra, Devyani; Yung, Raymond (2017) Gaps in Aging Research as it Applies to Rheumatologic Clinical Care. Clin Geriatr Med 33:119-133
Manu, Erika R; Mody, Lona; McNamara, Sara E et al. (2017) Advance Directives and Care Received by Older Nursing Home Residents. Am J Hosp Palliat Care 34:105-110

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