Studies in animal models of aging have suggested that there is a reduced potenfial for adipocyte maturation during the aging process. This could result in a defective capacity for storage of excess energy during overfeeding, and adipose fissue dysfunction. The resulfing abnormalifies in systemic lipid and glucose metabolism (including insulin resistance) are known contributors to risk for cardiovascular disease, a major cause of disability in the elderiy. We have recently found that when compared to Caucasian controls matched for age, gender and body composifion, young lean Asian Indians have much larger adipocytes and lower indices of new adipocyte formafion, which are associated with a significant reducfion in insulin sensifivity. Our hypothesis is that in older adults a reduced ability to form new adipocytes (whether through lack of proliferation or maturation arrest), in combinafion with adipocyte lepfin resistance, induces adipose fissue dysfuncfion and insulin resistance.
The specific aims that we will test are the following: 1. To determine in subcutaneous abdominal fat if there are age-related differences in the size of the adipocytes, expression of genes involved in new adipocyte formafion (such as pref-1, INSIG-1, PPARgamma), and leptin sensifivity (lepfin receptor, S0CS3, PTP1B, AMPK phosphorylafion). 2. To determine if there are age-related differences in adipose tissue triglycerides kinetics (triglyceride synthesis, net lipolysis, glyceroneogenesis) and adipocyte proliferafion using long-term ^H20 labeling. We will study non-diabefic young and older volunteers matched for gender, body fat content, and fat distribution. The results of this study will provide the necessary preliminary information to apply for larger grants to evaluate the role of adipose fissue dysfuncfion in the development of metabolic abnormalifies associated with aging.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Texas Medical Br Galveston
United States
Zip Code
Tan, Alai; Holmes, Holly M; Kuo, Yong-Fang et al. (2015) Coadministration of co-trimoxazole with sulfonylureas: hypoglycemia events and pattern of use. J Gerontol A Biol Sci Med Sci 70:247-54
Porter, Craig; Reidy, Paul T; Bhattarai, Nisha et al. (2015) Resistance Exercise Training Alters Mitochondrial Function in Human Skeletal Muscle. Med Sci Sports Exerc 47:1922-31
Bryant, Mon S; Rintala, Diana H; Hou, Jyh-Gong et al. (2015) Relationship of falls and fear of falling to activity limitations and physical inactivity in Parkinson's disease. J Aging Phys Act 23:187-93
Zgaljardic, Dennis J; Durham, William J; Mossberg, Kurt A et al. (2014) Neuropsychological and physiological correlates of fatigue following traumatic brain injury. Brain Inj 28:389-97
Ottenbacher, Allison J; Snih, Soham Al; Bindawas, Saad M et al. (2014) Role of physical activity in reducing cognitive decline in older Mexican-American adults. J Am Geriatr Soc 62:1786-91
Paddon-Jones, Douglas; Leidy, Heather (2014) Dietary protein and muscle in older persons. Curr Opin Clin Nutr Metab Care 17:5-11
Bindawas, Saad M; Graham, James E; Karmarkar, Amol M et al. (2014) Trajectories in functional recovery for patients receiving inpatient rehabilitation for unilateral hip or knee replacement. Arch Gerontol Geriatr 58:344-9
Padubidri, Anokha; Al Snih, Soham; Samper-Ternent, Rafael et al. (2014) Falls and cognitive decline in Mexican Americans 75 years and older. Clin Interv Aging 9:719-26
Porter, Craig; Herndon, David N; Børsheim, Elisabet et al. (2014) Uncoupled skeletal muscle mitochondria contribute to hypermetabolism in severely burned adults. Am J Physiol Endocrinol Metab 307:E462-7
Lin, Yi-Pin; Benoit, Vivian; Yang, Xiuli et al. (2014) Strain-specific variation of the decorin-binding adhesin DbpA influences the tissue tropism of the lyme disease spirochete. PLoS Pathog 10:e1004238

Showing the most recent 10 out of 138 publications