Studies in animal models of aging have suggested that there is a reduced potenfial for adipocyte maturation during the aging process. This could result in a defective capacity for storage of excess energy during overfeeding, and adipose fissue dysfunction. The resulfing abnormalifies in systemic lipid and glucose metabolism (including insulin resistance) are known contributors to risk for cardiovascular disease, a major cause of disability in the elderiy. We have recently found that when compared to Caucasian controls matched for age, gender and body composifion, young lean Asian Indians have much larger adipocytes and lower indices of new adipocyte formafion, which are associated with a significant reducfion in insulin sensifivity. Our hypothesis is that in older adults a reduced ability to form new adipocytes (whether through lack of proliferation or maturation arrest), in combinafion with adipocyte lepfin resistance, induces adipose fissue dysfuncfion and insulin resistance.
The specific aims that we will test are the following: 1. To determine in subcutaneous abdominal fat if there are age-related differences in the size of the adipocytes, expression of genes involved in new adipocyte formafion (such as pref-1, INSIG-1, PPARgamma), and leptin sensifivity (lepfin receptor, S0CS3, PTP1B, AMPK phosphorylafion). 2. To determine if there are age-related differences in adipose tissue triglycerides kinetics (triglyceride synthesis, net lipolysis, glyceroneogenesis) and adipocyte proliferafion using long-term ^H20 labeling. We will study non-diabefic young and older volunteers matched for gender, body fat content, and fat distribution. The results of this study will provide the necessary preliminary information to apply for larger grants to evaluate the role of adipose fissue dysfuncfion in the development of metabolic abnormalifies associated with aging.
|Valderrama-Hinds, Luis M; Al Snih, Soham; Chen, Nai-Wei et al. (2018) Falls in Mexican older adults aged 60 years and older. Aging Clin Exp Res 30:1345-1351|
|Raji, Mukaila A; Kuo, Yong-Fang; Adhikari, Deepak et al. (2018) Decline in opioid prescribing after federal rescheduling of hydrocodone products. Pharmacoepidemiol Drug Saf 27:513-519|
|McNeil, John J; Nelson, Mark R; Woods, Robyn L et al. (2018) Effect of Aspirin on All-Cause Mortality in the Healthy Elderly. N Engl J Med 379:1519-1528|
|Middleton, Addie; Kuo, Yong-Fang; Graham, James E et al. (2018) Readmission Patterns Over 90-Day Episodes of Care Among Medicare Fee-for-Service Beneficiaries Discharged to Post-acute Care. J Am Med Dir Assoc 19:896-901|
|Bhasin, Shalender; Gill, Thomas M; Reuben, David B et al. (2018) Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE): A Cluster-Randomized Pragmatic Trial of a Multifactorial Fall Injury Prevention Strategy: Design and Methods. J Gerontol A Biol Sci Med Sci 73:1053-1061|
|Iqbal, Fatima; Durham, William J; Melhem, Ayyash et al. (2018) Sex-dependent difference in the relationship between adipose-tissue cholesterol efflux and estradiol concentrations in young healthy humans. Int J Dev Neurosci 64:59-62|
|Downer, Brian; González-González, Cesar; Goldman, Noreen et al. (2018) The effect of adult children living in the United States on the likelihood of cognitive impairment for older parents living in Mexico. Ethn Health 23:57-71|
|Baillargeon, Jacques; Kuo, Yong-Fang; Westra, Jordan R et al. (2018) Testosterone Prescribing in the United States, 2002-2016. JAMA 320:200-202|
|Housten, Ashley J; Pappadis, Monique R; Krishnan, Shilpa et al. (2018) Resistance to discontinuing breast cancer screening in older women: A qualitative study. Psychooncology 27:1635-1641|
|Kuo, Yong-Fang; Raji, Mukaila A; Liaw, Victor et al. (2018) Opioid Prescriptions in Older Medicare Beneficiaries After the 2014 Federal Rescheduling of Hydrocodone Products. J Am Geriatr Soc 66:945-953|
Showing the most recent 10 out of 408 publications