The objective of the Pilot/Exploratory Studies Core (PESC) of the Duke Pepper OAIC is to conduct pilot studies to acquire information needed to design more definitive, larger studies to understand and modify multiple pathways of functional decline.
The specific aims are to generate novel ideas for pilots studies;to solicit, select and provide research funding for the highest quality pilot studies;to facilitate successful completion of the pilot studies and their development into externally funded, larger grants;to attract promising junior investigators to aging research;to foster multi-disciplinary/translational research;to educate developing investigators about the logistics and science of pilot studies via an innovative Pilot Studies Workshop, to share our expertise with the Pilot Studies Workshop to other Pepper OAlCs in collaboration with the OAIC Coordinating Center at Wake Forest University, to use small exploratory pilot monies as a rapid response mechanism to take advantage of cutting edge areas;and to contribute to other important NIA pilot mechanisms. The PESC solicits and selects high quality pilot studies from across Duke University Medical Center using rigorous external peer review. The PESC monitors study progress and assists in the development of larger grant proposals from pilot study findings. Three pilot studies are proposed in the first two years. PES-1 examines the role of skeletal muscle changes to different training regimens and evaluates the contribution of these changes to functional performance in the older adults. PES-2 addresses the problem of severe sepsis and multiple organ dysfunction syndrome by determining the effects of exercise on organ and immune cell mitochondrial biogenesis during sepsis. PES-3 addresses how the functional trajectory of patients with an index disease (diabetes for this study) is worsened by the presence of co-existing medical conditions (cognitive impairment). The PESC impacts public health by performing studies that develop knowledge to maintain or restore independence in older Americans.

Public Health Relevance

The pilot study research performed in the Duke Pepper OAIC PESC will generate the preliminary information needed to conduct the best studies of more effective ways to maintain or restore independence in older persons. The PESC supports research and training directed towards improving the health, independence, and quality of life of older Americans.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG028716-07
Application #
8381496
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8)
Project Start
Project End
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
7
Fiscal Year
2012
Total Cost
$22,242
Indirect Cost
$8,074
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Lee, Richard H; Pearson, Megan; Lyles, Kenneth W et al. (2016) Geographic scope and accessibility of a centralized, electronic consult program for patients with recent fracture. Rural Remote Health 16:3440
Cher, Wei Liang; Utturkar, Gangadhar M; Spritzer, Charles E et al. (2016) An analysis of changes in in vivo cartilage thickness of the healthy ankle following dynamic activity. J Biomech 49:3026-3030
Schaefer, Jonathan D; Caspi, Avshalom; Belsky, Daniel W et al. (2016) Enduring Mental Health: Prevalence and Prediction. J Abnorm Psychol :
Belsky, Daniel W; Moffitt, Terrie E; Corcoran, David L et al. (2016) The Genetics of Success: How Single-Nucleotide Polymorphisms Associated With Educational Attainment Relate to Life-Course Development. Psychol Sci 27:957-72
Zeng, Yi; Nie, Chao; Min, Junxia et al. (2016) Novel loci and pathways significantly associated with longevity. Sci Rep 6:21243
Bartlett, David B; Connelly, Margery A; AbouAssi, Hiba et al. (2016) A novel inflammatory biomarker, GlycA, associates with disease activity in rheumatoid arthritis and cardio-metabolic risk in BMI-matched controls. Arthritis Res Ther 18:86
Hsueh, Ming-Feng; Khabut, Areej; Kjellström, Sven et al. (2016) Elucidating the Molecular Composition of Cartilage by Proteomics. J Proteome Res 15:374-88
Dungan, Jennifer R; Qin, Xuejun; Horne, Benjamin D et al. (2016) Case-Only Survival Analysis Reveals Unique Effects of Genotype, Sex, and Coronary Disease Severity on Survivorship. PLoS One 11:e0154856
Whitson, Heather E; Duan-Porter, Wei; Schmader, Kenneth E et al. (2016) Physical Resilience in Older Adults: Systematic Review and Development of an Emerging Construct. J Gerontol A Biol Sci Med Sci 71:489-95
Porter Starr, Kathryn N; Pieper, Carl F; Orenduff, Melissa C et al. (2016) Improved Function With Enhanced Protein Intake per Meal: A Pilot Study of Weight Reduction in Frail, Obese Older Adults. J Gerontol A Biol Sci Med Sci 71:1369-75

Showing the most recent 10 out of 361 publications