PESC The objective ofthe Pilot/Exploratory Studies Core (PESC) ofthe Duke Pepper OAIC is to conduct pilot studies to acquire information needed to design more definitive, larger studies to understand and modify multiple pathways of functional decline.
The specific aims are to generate novel ideas for pilots studies;to solicit, select and provide research funding for the highest quality pilot studies;to facilitate successful completion of the pilot studies and their development into externally funded, larger grants;to attract promising junior investigators to aging research;to foster multi-disciplinary/translational research;to educate developing investigators about the logistics and science of pilot studies via an innovative Pilot Studies Workshop, to share our expertise with the Pilot Studies Workshop to other Pepper OAICs in collaboration with the OAIC Coordinating Center at Wake Forest University, to use small exploratory pilot monies as a rapid response mechanism to take advantage of cutting edge areas;and to contribute to other important NIA pilot mechanisms. The PESC solicits and selects high quality pilot studies from across Duke University Medical Center using rigorous external peer review. The PESC monitors study progress and assists in the development of larger grant proposals from pilot study findings. Three pilot studies are proposed in the first two years. PES-1 investigates the molecular basis of sarcopenia. PES-2 explores innovative methods to phenotype urge urinary incontinence and to predict response to therapy. PES-3 will validate novel measures of vlsual function and real-world independence in older macular disease patients as a necessary step toward planning the Memory or Reasoning Enhanced Low Vision Rehabilitation trial. The PESC impacts public health by performing studies! that develop knowledge to maintain or restore independence in older Americans.

Public Health Relevance

The pilot study research performed in the Duke Pepper OAIC PESC will generate the preliminary information needed to conduct the best studies of more effective ways to maintain or restore independence in older persons. The PESC supports research and training directed towards improving the health, independence, and quality of life |of older Americans.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG028716-09
Application #
8695269
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
9
Fiscal Year
2014
Total Cost
$77,103
Indirect Cost
$27,993
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
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