PESC The objective ofthe Pilot/Exploratory Studies Core (PESC) ofthe Duke Pepper OAIC is to conduct pilot studies to acquire information needed to design more definitive, larger studies to understand and modify multiple pathways of functional decline.
The specific aims are to generate novel ideas for pilots studies;to solicit, select and provide research funding for the highest quality pilot studies;to facilitate successful completion of the pilot studies and their development into externally funded, larger grants;to attract promising junior investigators to aging research;to foster multi-disciplinary/translational research;to educate developing investigators about the logistics and science of pilot studies via an innovative Pilot Studies Workshop, to share our expertise with the Pilot Studies Workshop to other Pepper OAICs in collaboration with the OAIC Coordinating Center at Wake Forest University, to use small exploratory pilot monies as a rapid response mechanism to take advantage of cutting edge areas;and to contribute to other important NIA pilot mechanisms. The PESC solicits and selects high quality pilot studies from across Duke University Medical Center using rigorous external peer review. The PESC monitors study progress and assists in the development of larger grant proposals from pilot study findings. Three pilot studies are proposed in the first two years. PES-1 investigates the molecular basis of sarcopenia. PES-2 explores innovative methods to phenotype urge urinary incontinence and to predict response to therapy. PES-3 will validate novel measures of vlsual function and real-world independence in older macular disease patients as a necessary step toward planning the Memory or Reasoning Enhanced Low Vision Rehabilitation trial. The PESC impacts public health by performing studies! that develop knowledge to maintain or restore independence in older Americans.

Public Health Relevance

The pilot study research performed in the Duke Pepper OAIC PESC will generate the preliminary information needed to conduct the best studies of more effective ways to maintain or restore independence in older persons. The PESC supports research and training directed towards improving the health, independence, and quality of life |of older Americans.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
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Special Emphasis Panel (ZAG1-ZIJ-8)
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Duke University
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Huffman, K M; Pieper, C F; Hall, K S et al. (2015) Self-efficacy for exercise, more than disease-related factors, is associated with objectively assessed exercise time and sedentary behaviour in rheumatoid arthritis. Scand J Rheumatol 44:106-10
Adams, Rebecca N; Mosher, Catherine E; Blair, Cindy K et al. (2015) Cancer survivors' uptake and adherence in diet and exercise intervention trials: an integrative data analysis. Cancer 121:77-83
Huffman, Kim M; Koves, Timothy R; Hubal, Monica J et al. (2014) Metabolite signatures of exercise training in human skeletal muscle relate to mitochondrial remodelling and cardiometabolic fitness. Diabetologia 57:2282-95
Orlowsky, Eric W; Stabler, Thomas V; Montell, Eulàlia et al. (2014) Monosodium urate crystal induced macrophage inflammation is attenuated by chondroitin sulphate: pre-clinical model for gout prophylaxis? BMC Musculoskelet Disord 15:318
Yin, Zhaoxue; Shi, Xiaoming; Kraus, Virginia B et al. (2014) Gender-dependent association of body mass index and waist circumference with disability in the Chinese oldest old. Obesity (Silver Spring) 22:1918-25
Hybels, Celia F; George, Linda K; Blazer, Dan G et al. (2014) Inflammation and Coagulation as Mediators in the Relationships Between Religious Attendance and Functional Limitations in Older Adults. J Aging Health 26:679-697
Nelson, Amanda E; Elstad, Emily; DeVellis, Robert F et al. (2014) Composite measures of multi-joint symptoms, but not of radiographic osteoarthritis, are associated with functional outcomes: the Johnston County Osteoarthritis Project. Disabil Rehabil 36:300-6
Whitson, Heather E; Arnold, Alice M; Yee, Laura M et al. (2014) Serum carboxymethyl-lysine, disability, and frailty in older persons: the Cardiovascular Health Study. J Gerontol A Biol Sci Med Sci 69:710-6
Hanlon, Joseph T; Semla, Todd P; Schmader, Kenneth E (2014) Medication misadventures in older adults: literature from 2013. J Am Geriatr Soc 62:1950-3
Peterson, Matthew J; Williams, Nanyamka; Caves, Kevin et al. (2014) A pilot study of partial unweighted treadmill training in mobility-impaired older adults. Biomed Res Int 2014:321048

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