The overall goal of the proposed Arkansas Older Americans Independence Center (OAIC) is to promote the translation of basic and physiological research on cardiac and skeletal muscle dysfunction in aging and disease to clinically relevant outcomes that ultimately have a positive influence on the standard of care. The role of the Biostatistics and Data Management Resource Core (RC1) in the OAIC is to facilitate the conduct of all research affiliated with the core by ensuring that each research protocol benefits from statistical and data management support. OAIC investigators will work collaboratively with the RC1 from the outset in planning a research study to ensure that RCl sen/ices are maximally beneficial and effective. Early statistical support ensures that studies have the statistical power to answer their research questions while minimizing resource utilization, animal numbers, and potential risk of harm to subjects. Eariy data management support ensures reuse of electronic case report forms (eCRFs) and common data elements (CDEs), thereby minimizing resources expended on data management while at the same time ensuring compliance with privacy and confidentiality. Our IRB already has familiarity with, and has approved, the use of eCRFs at UAMS. Coordinated statistical support, eCRFs, and CDEs will unify and bring coherence to OAIC research as well as improve its potential for rapid dissemination, as all investigators will share common approaches to analysis and common understandings of definitions and measures. The core will achieve its goals through the following specific aims:
Specific Aim 1. Assist investigators with designing research plans that are statistically sound and utilize efficient and secure data management procedures.
Specific Aim 2. Assist investigators with the conduct of research through data management services and appropriate statistical analyses.
Specific Aim 3. Educate investigators in relevant areas of biostatistics and biomedical informatics.

Public Health Relevance

Coordinated statistical support and data management efforts will unify and bring coherence to OAIC research as well as improve its potential for rapid dissemination as all investigators will share common approaches to analysis and common understandings of definitions and measures.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Arkansas for Medical Sciences
Little Rock
United States
Zip Code
Zhang, Xiaomin; Williams, Emmanuel D; Azhar, Gohar et al. (2016) Does p49/STRAP, a SRF-binding protein (SRFBP1), modulate cardiac mitochondrial function in aging? Exp Gerontol 82:150-9
Alagpulinsa, David A; Ayyadevara, Srinivas; Yaccoby, Shmuel et al. (2016) A Cyclin-Dependent Kinase Inhibitor, Dinaciclib, Impairs Homologous Recombination and Sensitizes Multiple Myeloma Cells to PARP Inhibition. Mol Cancer Ther 15:241-50
Kim, Il-Young; Schutzler, Scott; Schrader, Amy et al. (2016) The anabolic response to a meal containing different amounts of protein is not limited by the maximal stimulation of protein synthesis in healthy young adults. Am J Physiol Endocrinol Metab 310:E73-80
Carvalho, Eugenia; Lopaschuk, Gary D; Børsheim, Elisabet et al. (2016) Reply to Katlandur, Ozbek, and Keser. Am J Physiol Endocrinol Metab 310:E863
Baum, Jamie I; Kim, Il-Young; Wolfe, Robert R (2016) Protein Consumption and the Elderly: What Is the Optimal Level of Intake? Nutrients 8:
Deak, Ferenc; Freeman, Willard M; Ungvari, Zoltan et al. (2016) Recent Developments in Understanding Brain Aging: Implications for Alzheimer's Disease and Vascular Cognitive Impairment. J Gerontol A Biol Sci Med Sci 71:13-20
Tarantini, Stefano; Giles, Cory B; Wren, Jonathan D et al. (2016) IGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis. Age (Dordr) 38:239-258
Perry Jr, Richard A; Brown, Lemuel A; Lee, David E et al. (2016) Differential effects of leucine supplementation in young and aged mice at the onset of skeletal muscle regeneration. Mech Ageing Dev 157:7-16
Tarantini, Stefano; Tucsek, Zsuzsanna; Valcarcel-Ares, M Noa et al. (2016) Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging. Age (Dordr) 38:273-289
Penthala, Narsimha Reddy; Yadlapalli, Jaishankar K B; Parkin, Sean et al. (2016) Crystal structures of (Z)-5-[2-(benzo[b]thio-phen-2-yl)-1-(3,5-di-meth-oxy-phen-yl)ethen-yl]-1H-tetra-zole and (Z)-5-[2-(benzo[b]thio-phen-3-yl)-1-(3,4,5-tri-meth-oxy-phen-yl)ethen-yl]-1H-tetra-zole. Acta Crystallogr E Crystallogr Commun 72:652-5

Showing the most recent 10 out of 62 publications