The goal of the OAIC Pilot/Exploratory Studies Core is to support the planning of future independently funded studies with a high potential to advance our understanding of the underlying mechanisms of and preventive interventions for sarcopenia and physical disability in older Americans. This goal is achieved by soliciting and selecting promising innovative pilot and exploratory studies that address the overall OAIC research theme of 'sarcopenia and prevention of disability'. The core fosters pilot and exploratory studies by ensuring the availability of optimal infrastructure, environment, funding, expertise, and instrumentation. The core leaders monitor study progress, assist in the analysis and interpretation of results, and provide guidance in translating pilot data into high quality and original research study proposals that successfully compete for independent extramural funding. The provision of funds for pilot and exploratory studies supports Junior Scholars in their efforts to develop research careers in aging. The core also allows accomplished investigators in the area of aging to gather data which extend and broaden their focus. Finally, the core serves as a vehicle to encourage and facilitate experienced investigators traditionally working in other research fields, such as biomechanics, physiology or pulmonology, to expand their research focus on aging. This broadens the pool of talent contributing to advances in understanding and preventing sarcopenia and disability. We are highly successful in translating findings from our pilot and exploratory studies from the previous funding cycle. Of a total of 19 directly supported or jointly supported pilot studies, 13 have garnered additional funding through NIH, VA and foundation sources;and the remaining 6 are still in the data collection phase, or have grants pending and in preparation. One exploratory and two pilot studies, are proposed in this application. The resultant portfolio of pilot/exploratory study proposals provides a broad variety of interdisciplinary approaches in addressing the OAIC research theme.

Public Health Relevance

All pilot and exploratory studies test novel research hypotheses related to the common OAIC research theme 'sarcopenia and prevention of disability'. In addition, their findings will lead to new information that is necessary in developing interventions to avert sarcopenia, physical function decline and possibly disability in older people.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG028740-07
Application #
8459410
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
7
Fiscal Year
2013
Total Cost
$198,114
Indirect Cost
$62,882
Name
University of Florida
Department
Type
DUNS #
969663814
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Brakenridge, Scott C; Efron, Philip A; Stortz, Julie A et al. (2018) The impact of age on the innate immune response and outcomes after severe sepsis/septic shock in trauma and surgical intensive care unit patients. J Trauma Acute Care Surg 85:247-255
Shenkman, Elizabeth; Hurt, Myra; Hogan, William et al. (2018) OneFlorida Clinical Research Consortium: Linking a Clinical and Translational Science Institute With a Community-Based Distributive Medical Education Model. Acad Med 93:451-455
Hernandez, Abbi R; Hernandez, Caesar M; Campos, Keila et al. (2018) A Ketogenic Diet Improves Cognition and Has Biochemical Effects in Prefrontal Cortex That Are Dissociable From Hippocampus. Front Aging Neurosci 10:391
Liu, Xinyue; Carney, Paul R; Bussing, Regina et al. (2018) Stimulants Do Not Increase the Risk of Seizure-Related Hospitalizations in Children with Epilepsy. J Child Adolesc Psychopharmacol 28:111-116
Dahodwala, Nabila; Shah, Krunal; He, Ying et al. (2018) Sex disparities in access to caregiving in Parkinson disease. Neurology 90:e48-e54
Buford, Thomas W; Manini, Todd M; Kairalla, John A et al. (2018) Mitochondrial DNA Sequence Variants Associated With Blood Pressure Among 2 Cohorts of Older Adults. J Am Heart Assoc 7:e010009
Rillamas-Sun, Eileen; LaMonte, Michael J; Evenson, Kelly R et al. (2018) The Influence of Physical Activity and Sedentary Behavior on Living to Age 85 Years Without Disease and Disability in Older Women. J Gerontol A Biol Sci Med Sci 73:1525-1531
Chen, Haiying; Rejeski, W Jack; Gill, Thomas M et al. (2018) A Comparison of Self-report Indices of Major Mobility Disability to Failure on the 400-m Walk Test: The LIFE Study. J Gerontol A Biol Sci Med Sci 73:513-518
Bihorac, Azra; Ozrazgat-Baslanti, Tezcan; Ebadi, Ashkan et al. (2018) MySurgeryRisk: Development and Validation of a Machine-learning Risk Algorithm for Major Complications and Death After Surgery. Ann Surg :
Ravyts, Scott G; Dzierzewski, Joseph M; Grah, Stephanie C et al. (2018) Sleep and Pain in Mid- to Late-Life: An Exploration of Day-to-Day Pain Inconsistency. Clin Gerontol 41:123-129

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