Data analysis in aging research poses distinctive challenges that require careful selection and tailoring of statistical methods, because of older adults'multiple comorbidities / medications, competing rtsks, and high drop out rates due to death or disability. In addition. In the current context of limited health care resources in the face of an Impending surge in the number of older Americans, consideration has to be given to the costeffectiveness of interventions to restore or maintain the independence of older adults. ACEC will provide important guidance to OAIC researchers and projects, as well as other UCLA aging researchers, in the selection and conduct of appropriate statistical and economic analyses. The Analysis/Cost-Effectiveness Core will provide analytic support in research study design (focusing on power considerations), statistical data analysis, and interpretation and accurate description of findings, for: ? OAIC Career Development Awardees, ? OAIC supported pilots and development projects, ? UCLA junior researchers conducting research that meet the UCLA OAIC mission, theme, and goals, ? Externally funded UCLA research projects that meet the UCLA OAIC mission, theme, and goals The core will also provide training workshops / tutorial seminars on state-of-the-art methods for statistical data analysis, comparative effectiveness studies, and cost effectiveness analysis. It will also assess the cost-effectiveness of successful clinical interventions studied in the OAIC Finally, the ACEC will disseminate new analytic approaches to comparative effectiveness studies, as they become available. In collaboration with the other OAIC resource cores, ACEC will support externally funded aging research projects, promote aging research aimed at maintaining the independence of older adults, ensure the quality of its products, hasten its translation into clinical practice, and nurture a new cohort of aging researchers and future leaders.

Public Health Relevance

The aging ofthe baby boomers and the surprising increase In disability rates in aging pre-boomer cohorts has increased the urgency for translating into clinical practice, research aimed at maintaining the independence of older Americans. The Analysis and Cost Effectiveness resource core will provide analysis support in biostatistical methods, comparative effectiveness methods, and cost effectiveness analysis to UCLA aging researchers to promote such research and hasten its translation into clinical practice.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
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Special Emphasis Panel (ZAG1-ZIJ-8 (M1))
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University of California Los Angeles
Los Angeles
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Hernandez, Rosalba; Cheung, Elaine; Liao, Minli et al. (2017) The Association Between Depressive Symptoms and Cognitive Functioning in Older Hispanic/Latino Adults Enrolled in an Exercise Intervention. J Aging Health :898264317696776
Lee, A D; Spiegel, B M; Hays, R D et al. (2017) Gastrointestinal symptom severity in irritable bowel syndrome, inflammatory bowel disease and the general population. Neurogastroenterol Motil 29:
Lee, Yvonne C; Karlamangla, Arun S; Yu, Zhi et al. (2017) Pain Severity in Relation to the Final Menstrual Period in a Prospective Multiethnic Observational Cohort: Results From the Study of Women's Health Across the Nation. J Pain 18:178-187
Cho, Hyong Jin; Savitz, Jonathan; Dantzer, Robert et al. (2017) Sleep disturbance and kynurenine metabolism in depression. J Psychosom Res 99:1-7
Lê-Scherban, Félice; Brenner, Allison B; Hicken, Margaret T et al. (2017) Child and adult socioeconomic status and the cortisol response to acute stress: Evidence from the Multi-Ethnic Study of Atherosclerosis. Psychosom Med :
Tsai, Kim M; Dahl, Ronald E; Irwin, Michael R et al. (2017) The Roles of Parental Support and Family Stress in Adolescent Sleep. Child Dev :
Chiang, Jessica J; Bower, Julienne E; Irwin, Michael R et al. (2017) Adiposity moderates links from early adversity and depressive symptoms to inflammatory reactivity to acute stress during late adolescence. Brain Behav Immun 66:146-155
Chiang, Jessica J; Kim, Joanna J; Almeida, David M et al. (2017) Sleep Efficiency Modulates Associations Between Family Stress and Adolescent Depressive Symptoms and Negative Affect. J Adolesc Health 61:501-507
Bates-Jensen, Barbara M; McCreath, Heather E; Patlan, Anabel (2017) Subepidermal moisture detection of pressure induced tissue damage on the trunk: The pressure ulcer detection study outcomes. Wound Repair Regen 25:502-511
Lake, Jordan E; Popov, Mikhail; Post, Wendy S et al. (2017) Visceral fat is associated with brain structure independent of human immunodeficiency virus infection status. J Neurovirol 23:385-393

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