Overview. The overarching purpose of the UCLA Pilot Exploratory Studies Core (PESC) is to promote innovative basic, clinical and translational research, conducted by collaborating teams of junior and senior investigators, that falls within the UCLA's research theme and carries out the Center's goals. These studies will have one or more of the following objectives: a) provide preliminary studies on which subsequent, larger basic or clinical investigations will be based, b) develop new basic or clinical methodologies that surmount critical barriers to progress in a given discipline, thus opening new research avenues;c) develop novel multidisciplinary research approaches to address complex geriatrics research questions;d) accomplish bidirectional basic and clinical sciences translation;and e) identify diagnostic and/or treatment strategies that bring discoveries to the bedside in order to improve health and optimize function of geriatric patients. Leadership. Gail A. Greendale, MD, Professor of Medicine/Geriatrics, who conducts research in menopause, mammographic density, osteoporosis, &physical functioning, will lead the PESC multidisciplinary team. The co-leaders will be Rita Effros, PhD, Professor of Pathology/Laboratory Medicine, who studies immunosenescence and Peifeng Hu, PhD, MD, Assoc. Professor of Medicine/Geriatrics, who studies relations among biomarkers, psychosocial factors and health outcomes in older adults. Pilot Processes. There will be clear processes for selection of full pilots, monitoring progress of pilots, and developing pilots into independently funded research awards. Selection will consist of a staged process that includes a request for proposals;request for full applications from meritorious applicants;and a series of reviews culminating with final selection by the Executive Committee, External Advisory Board and External Selection Panel. Each pilot will be monitored by a PESC liaison;monitoring will include monthly reports;quarterly meetings with the liaison;annual presentation at the OAIC Seminar Series;and annual presentation to the External Advisors. There will also be a rapid pilot program for which we have set aside $25K to make awards during year 1. The rapid pilot program will make fast-turn-around grants of up to $10,000, to allow the research of junior investigators to advance expediently. Pilots. Three full pilots are proposed. These are: 1) Gene expression analysis of age-related, focal muscle mitochondrial defects;2) Mandibular vs. long bone marrow stromal cell based therapy for implant placement;3) How do new models of care for older adults spread into routine practice?

Public Health Relevance

The infrastructure provided by the PESC is an essential building block in the creation of a geriatrics-focused research environment. The PESC, by offering pilot funding and research mentorship, will foster the development and translation of emerging science, serve as a stepping stone for new researchers beginning a career in aging and attracting established researchers to geriatrics research. Thus, the PESC will play a critical role in the creation of new scientists and new science aimed at discoveries to help elders age better.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Los Angeles
Los Angeles
United States
Zip Code
Jennings, Lee A; Zingmond, David; Louie, Rachel et al. (2016) Use of the Physician Orders for Life-Sustaining Treatment among California Nursing Home Residents. J Gen Intern Med 31:1119-26
Fung, Constance H; Martin, Jennifer L; Josephson, Karen et al. (2016) Efficacy of Cognitive Behavioral Therapy for Insomnia in Older Adults With Occult Sleep-Disordered Breathing. Psychosom Med 78:629-39
Mosqueda, Laura; Burnight, Kerry; Gironda, Melanie W et al. (2016) The Abuse Intervention Model: A Pragmatic Approach to Intervention for Elder Mistreatment. J Am Geriatr Soc 64:1879-83
Lake, Jordan E; Popov, Mikhail; Post, Wendy S et al. (2016) Visceral fat is associated with brain structure independent of human immunodeficiency virus infection status. J Neurovirol :
Kwon, Ivy; Bharmal, Nazleen; Choi, Sarah et al. (2016) Older Ethnic Minority Women's Perceptions of Stroke Prevention and Walking. Womens Health Issues 26:80-6
Carroll, Judith E; Cole, Steven W; Seeman, Teresa E et al. (2016) Partial sleep deprivation activates the DNA damage response (DDR) and the senescence-associated secretory phenotype (SASP) in aged adult humans. Brain Behav Immun 51:223-9
Lee, Yvonne C; Karlamangla, Arun S; Yu, Zhi et al. (2016) Pain Severity in Relation to the Final Menstrual Period in a Prospective Multiethnic Observational Cohort: Results from the Study of Women's Health Across the Nation (SWAN). J Pain :
Bjurstrom, Martin F; Irwin, Michael R (2016) Polysomnographic characteristics in nonmalignant chronic pain populations: A review of controlled studies. Sleep Med Rev 26:74-86
Huynh, Virginia W; Guan, Shu-Sha Angie; Almeida, David M et al. (2016) Everyday discrimination and diurnal cortisol during adolescence. Horm Behav 80:76-81
Mendez-Luck, Carolyn A; Walker, Kara O; Luck, Jeff (2016) Preventive Services Use Among African American and Latino Adult Caregivers in South Los Angeles. Med Care 54:1098-1104

Showing the most recent 10 out of 340 publications