Although the prevalence of chronic disability in older individuals remains on the decline in the United States, the total number of individuals over the age of 65 with chronic disability is increasing (1, 2). Presently, limitations in mobility affect almost one in four individuals over age 65 and three quarters of those living in nursing homes (3). In non-disabled older individuals, limitations in mobility in such tasks as climbing stairs, and walking across a room have been defined as 'mobility disability' (4). To capture and assess mobility limitations in the elderly, performance tests of functional capacity have been developed and have been shown to be predictive of incident disability, institutionalization, and mortality (4, 5). In particular, walking ability alone, as measured by gait speed during a 4 M walk test, has been shown to be a strong predictor of subsequent ADL disability and mobility disability (6). In addition, validated highly reliable instruments to assess components of physical disability have also been developed and implemented in observational studies and clinical trials. More recently, testing protocols in selected animal models (rats, mice) have been developed to assess important endpoints related to impairments and functional limitations in these species.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG031679-04
Application #
8301621
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2011-07-15
Budget End
2012-05-31
Support Year
4
Fiscal Year
2011
Total Cost
$55,367
Indirect Cost
Name
Boston Medical Center
Department
Type
DUNS #
005492160
City
Boston
State
MA
Country
United States
Zip Code
02118
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Jang, Il-Young; Jung, Hee-Won; Park, Hyelim et al. (2018) A multicomponent frailty intervention for socioeconomically vulnerable older adults: a designed-delay study. Clin Interv Aging 13:1799-1814
Kim, Dae Hyun (2018) Incorporating Quality of Life Prediction in Shared Decision Making About Transcatheter Aortic Valve Replacement. Circ Cardiovasc Qual Outcomes 11:e005097
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Datta, Rupak; Trentalange, Mark; Van Ness, Peter H et al. (2018) Serious adverse events of older adults in nursing home and community intervention trials. Contemp Clin Trials Commun 9:77-80
Wang, Chenchen; Schmid, Christopher H; Fielding, Roger A et al. (2018) Effect of tai chi versus aerobic exercise for fibromyalgia: comparative effectiveness randomized controlled trial. BMJ 360:k851
Miller, Michael E; Magaziner, Jay; Marsh, Anthony P et al. (2018) Gait Speed and Mobility Disability: Revisiting Meaningful Levels in Diverse Clinical Populations. J Am Geriatr Soc 66:954-961
Trombetti, Andrea; Hars, Mélany; Hsu, Fang-Chi et al. (2018) Effect of Physical Activity on Frailty: Secondary Analysis of a Randomized Controlled Trial. Ann Intern Med 168:309-316
Wanigatunga, Amal A; Manini, Todd M; Cook, Delilah R et al. (2018) Community-Based Activity and Sedentary Patterns Are Associated With Cognitive Performance in Mobility-Limited Older Adults. Front Aging Neurosci 10:341
Gagliano-Jucá, T; Storer, T W; Pencina, K M et al. (2018) Testosterone does not affect agrin cleavage in mobility-limited older men despite improvement in physical function. Andrology 6:29-36

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