This application for an Einstein Nathan Shock Center (E-NSC) of excellence in the basic biology of aging is a natural step for enhancement of ongoing research, to strengthen the broad continuum of science and to address these biology of aging issues in its relation to human health. We have assembled a cohort of 48 Einstein investigators, 13 Regional members and 4 national members involved in ongoing research in Biology of Aging.
The aims of the NSC are:1) To enhance and expand the ongoing basic biology of aging enterprise at the Einstein Institute for Aging Research, we will establish 3 Research Resource Cores that are unique (do not exist in other NSCs) and novel (in their use of technology): a) Cellular and Tissue Aging Core (Cuervo), will provide measurements of cellular homeostasis as well as molecular modifications of protein, lipid, nucleic acids, and organelles;b) Healthy Aging Physiology Core (Barzilai), will perform sophisticated integrative metabolic studies in rodents to determine 'healthy aging'physiology such as in vivo whole body and organ- specific metabolism, body composition and energy balance, exercise, cardiac and cognitive/functional physiology analyses;and, c) Genomics and Epigenomics of Aging Core (Vijg), will provide investigators with whole genome association data from human centenarians and controls to assess their gene of interest in relationship to human aging and diseases as well as sequence enrichment for next generation re-sequencing of candidate gene regions, and genome-wide ONA methylation analysis using advanced high throughput technology. 2) To facilitate the planning and coordination of aging biology research activities at Einstein and other regional research institutions, and program enhancement through a lecture series and a yearly retreat (Administrative Core). 3) To provide support and a suitable environment for new investigators including pilot &feasibility awards, a designated-mentor system, and co-direction of a graduate course in Biology of Aging. 4) To develop potential regional and/or national resource Centers, by reaching out to regional investigators, and extending Core usage benefits to members of other NSCs.

Agency
National Institute of Health (NIH)
Type
Center Core Grants (P30)
Project #
5P30AG038072-05
Application #
8709959
Study Section
Special Emphasis Panel (ZAG1)
Program Officer
Sierra, Felipe
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Bronx
State
NY
Country
United States
Zip Code
10461
Milman, Sofiya; Huffman, Derek M; Barzilai, Nir (2016) The Somatotropic Axis in Human Aging: Framework for the Current State of Knowledge and Future Research. Cell Metab 23:980-9
Justice, Jamie; Miller, Jordan D; Newman, John C et al. (2016) Frameworks for Proof-of-Concept Clinical Trials of Interventions That Target Fundamental Aging Processes. J Gerontol A Biol Sci Med Sci 71:1415-1423
Barzilai, Nir; Crandall, Jill P; Kritchevsky, Stephen B et al. (2016) Metformin as a Tool to Target Aging. Cell Metab 23:1060-5
Huffman, Derek M; Schafer, Marissa J; LeBrasseur, Nathan K (2016) Energetic interventions for healthspan and resiliency with aging. Exp Gerontol 86:73-83
Tanase, Maya; Urbanska, Aleksandra M; Zolla, Valerio et al. (2016) Role of Carbonyl Modifications on Aging-Associated Protein Aggregation. Sci Rep 6:19311
Baskovich, Brett; Hiraki, Susan; Upadhyay, Kinnari et al. (2016) Expanded genetic screening panel for the Ashkenazi Jewish population. Genet Med 18:522-8
Roshandel, Delnaz; Klein, Ronald; Klein, Barbara E K et al. (2016) New Locus for Skin Intrinsic Fluorescence in Type 1 Diabetes Also Associated With Blood and Skin Glycated Proteins. Diabetes 65:2060-71
Kaushik, Susmita; Cuervo, Ana Maria (2016) AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA. Autophagy 12:432-8
Huffman, Derek M; Farias Quipildor, Gabriela; Mao, Kai et al. (2016) Central insulin-like growth factor-1 (IGF-1) restores whole-body insulin action in a model of age-related insulin resistance and IGF-1 decline. Aging Cell 15:181-6
Martinez-Lopez, Nuria; Garcia-Macia, Marina; Sahu, Srabani et al. (2016) Autophagy in the CNS and Periphery Coordinate Lipophagy and Lipolysis in the Brown Adipose Tissue and Liver. Cell Metab 23:113-27

Showing the most recent 10 out of 77 publications