Our FHCRC/UW CFAR proposal focuses on three major themes: preventing HIV-1 infection, eradication and co-morbidities. Basic research in each of these areas will require sophisticated immunologic assessments, for example, target cell identification/quantification (HIV prevention), vaccine-induced immune responses (HIV prevention), immune activation status (pathogenesis) and latent cell identification/quantification (eradication). The Immunology Core will offer to all CFAR investigators innovative new and cutting-edge technologies (e.g., CyTOF, digital drop PCR and Cyntellect LEAP for single cell analyses) to assess molecular and cellular immune phenotypes and functions in diverse tissue types. The Core will dedicate its primary effort on training new/early investigators to apply these technologies to address fundamental research in the three areas. In addition, the core proposes to expand its scope to mucosal immunology, non-human primate immunology and the immunology of co-infections, and Seattle experts in these areas will join our core. The focus on new technologies and the addition of new experts place the Immunology Core in a very strong position to facilitate basic research in the new focus areas. In addition, the Core will continue to provide access to the humoral and cellular assays and expertise that currently comprise our Core.
The overarching goal of the Immunology Core is to facilitate cutting-edge immunologic assessments of diverse biologic specimen types to answer basic science questions related to HIV prevention, eradication and co-morbidities.
|Dombrowski, Julia C; Carey, James W; Pitts, Nicole et al. (2016) HIV provider and patient perspectives on the Development of a Health Department "Data to Care" Program: a qualitative study. BMC Public Health 16:491|
|Wang, Kerong; Chen, Wei-Ti; Zhang, Lin et al. (2016) Facilitators of and barriers to HIV self-management: Perspectives of HIV-positive women in China. Appl Nurs Res 32:91-97|
|Dross, Sandra E; Munson, Paul V; Kim, Se Eun et al. (2016) Kinetics of Myeloid-Derived Suppressor Cell Frequency and Function during Simian Immunodeficiency Virus Infection, Combination Antiretroviral Therapy, and Treatment Interruption. J Immunol :|
|Yang, Cui; Crane, Heidi M; Cropsey, Karen et al. (2016) Implementation of Computer-delivered Brief Alcohol Intervention in HIV Clinical Settings: Who Agrees to Participate? J Addict Res Ther 7:|
|Kohler, Pamela K; Tippett Barr, Beth A; KangÊ¼ombe, Anderson et al. (2016) Safety, Feasibility, and Acceptability of the PrePex Device for Adult Male Circumcision in Malawi. J Acquir Immune Defic Syndr 72 Suppl 1:S49-55|
|Hien, Ha Thuc Ai; Thanh, Tran Tan; Thu, Nguyen Thi Mai et al. (2016) Development and evaluation of a real-time polymerase chain reaction assay for the rapid detection of Talaromyces marneffei MP1 gene in human plasma. Mycoses :|
|Levine, Molly; Beck, Ingrid; Styrchak, Sheila et al. (2016) Comparison of Matrix-Based and Filter Paper-Based Systems for Transport of Plasma for HIV-1 RNA Quantification and Amplicon Preparation for Genotyping. J Clin Microbiol 54:1899-901|
|Kerani, Roxanne P; Herbeck, Joshua T; Buskin, Susan E et al. (2016) Evidence of Local HIV Transmission in the African Community of King County, Washington. J Immigr Minor Health :|
|Wilson, Kate S; Wanje, George; Yuhas, Krista et al. (2016) A Prospective Study of Intimate Partner Violence as a Risk Factor for Detectable Plasma Viral Load in HIV-Positive Women Engaged in Transactional Sex in Mombasa, Kenya. AIDS Behav 20:2065-77|
|Akullian, Adam N; Mukose, Aggrey; Levine, Gillian A et al. (2016) People living with HIV travel farther to access healthcare: a population-based geographic analysis from rural Uganda. J Int AIDS Soc 19:20171|
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