The AIDS Specimen Bank (ASB) Core provides expertly collected and cryopreserved biological specimens, linked to detailed clinical information to enable multidisciplinary research bridging laboratory-based basic science with clinical, behavioral and epidemiological investigations. Successful translational research depends on access to high quality specimens thus great attention much be given to how cells are frozen and whether they remain stable with full functionality during storage. The ASB Core has provided this expertise to the UCSF-GIVI CFAR research community since the Center its establishment in 1987. The ASB Core remains crucial to the CFAR translational research effort and has sought to expand the range of services it provides, keeping pace with the innovative new experimental directions initiated by CFAR investigators. In the current grant cycle, ASB has banked 135,414 biological samples and distributed 157,707 samples to interested investigators. ASB also offers consultation and training to early-career investigators, research staff and other trainees regarding specimen choice and biorepository procedures to ensure that sensitive biological samples are properly handled following distribution and that they are appropriate for the planned laboratory assays. ASB has an outstanding reputation for never having lost a specimen due to freezer malfunction, earthquakes, or power outages. ASB's state of the art inventory system can also quickly locate a single cryovial among the bank's 25 ultra-low and 13 liquid nitrogen freezers. ASB continues to seek new methods to improve specimen viability during cyostorage through changes in processing and freezing. Based on surveys of the needs of UCSF-GIVI-CFAR investigators ASB will expand the type of specimens its processes and stores for basic and translational research. ASB will provide also provide its services to support all CFAR members including those based at either domestic or international sites.

Public Health Relevance

The AIDS Specimen Bank Core is committed to supporting the multidisciplinary research mission of the UCSF-GIVI CFAR by providing expertise in the collection, processing, cryopreservation and distribution of well-characterized biological specimens to interested CFAR investigators. The Core closely monitors specimen quality and is constantly exploring new technologies to improve and extend its services. The Core also provides training to interested individuals including scientists located at international sites.

National Institute of Health (NIH)
Center Core Grants (P30)
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Special Emphasis Panel (ZAI1)
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University of California San Francisco
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Mmeje, Okeoma; van der Poel, Sheryl; Workneh, Meklit et al. (2015) Achieving pregnancy safely: perspectives on timed vaginal insemination among HIV-serodiscordant couples and health-care providers in Kisumu, Kenya. AIDS Care 27:6-Oct
Edwards, Jessie K; Cole, Stephen R; Adimora, Adaora et al. (2015) Illustration of a measure to combine viral suppression and viral rebound in studies of HIV therapy. J Acquir Immune Defic Syndr 68:241-4
Chan, Brian T; Weiser, Sheri D; Boum, Yap et al. (2015) Persistent HIV-related stigma in rural Uganda during a period of increasing HIV incidence despite treatment expansion. AIDS 29:83-90
Chan, Brian T; Weiser, Sheri D; Boum, Yap et al. (2015) Declining prevalence of probable depression among patients presenting for antiretroviral therapy in rural Uganda: the role of early treatment initiation. AIDS Behav 19:19-26
Psaros, Christina; Haberer, Jessica E; Boum 2nd, Yap et al. (2015) The factor structure and presentation of depression among HIV-positive adults in Uganda. AIDS Behav 19:27-33
Jagannathan, Prasanna; Eccles-James, Ijeoma; Bowen, Katherine et al. (2014) IFN?/IL-10 co-producing cells dominate the CD4 response to malaria in highly exposed children. PLoS Pathog 10:e1003864
Dworkin, Shari L; Lu, Tiffany; Grabe, Shelly et al. (2014) What community-level strategies are needed to secure women's property rights in Western Kenya? Laying the groundwork for a future structural HIV prevention intervention. AIDS Care 26:754-7
Liu, Albert Y; Yang, Qiyun; Huang, Yong et al. (2014) Strong relationship between oral dose and tenofovir hair levels in a randomized trial: hair as a potential adherence measure for pre-exposure prophylaxis (PrEP). PLoS One 9:e83736
Martinez, Priscilla; Tsai, Alexander C; Muzoora, Conrad et al. (2014) Reversal of the Kynurenine pathway of tryptophan catabolism may improve depression in ART-treated HIV-infected Ugandans. J Acquir Immune Defic Syndr 65:456-62
Rebeiro, Peter F; Horberg, Michael A; Gange, Stephen J et al. (2014) Strong agreement of nationally recommended retention measures from the Institute of Medicine and Department of Health and Human Services. PLoS One 9:e111772

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