The Clinical Core has been in operation for twenty years to provide services that foster the translational interface between basic science, clinical, behavioral, and epidemiologic investigators and HIV-infected patients.
The Specific Aims of the Clinical Core are: 1. To provide a Comprehensive Specimen Repository offering the efficient collection, processing, storage, quality assurance tracking, distribution, and shipping of clinical specimens obtained from wellcharacterized patients for collaborative investigations involving multiple research disciplines. 2. To provide an innovative Computerized Database and Informatics Service?the resources and equipment to store and access complex, interactive data and the expertise to assist with study design, identify subjects who meet entry criteria for research protocols, conduct appropriate data analyses and provide detailed and relevant interpretation of results. 3. To establish new methods and technologies to make clinical samples more readily accessible to CFAR members realizing that despite the numerous successes we have had in fostering innovative translational research, we must strive to improve this process. 4. To provide Research Training Services to support all levels (from students to research staff to seasoned faculty updating their skills) of domestic and international clinical research. While each of these services has been in operation since the beginning of our CFAR, each continues to grow and diversify substantially in response to investigator needs. Publications requiring Clinical Core services have continued to increase every year during the last funding period. Specimens are integrally linked with information in the Computerized Database, and this synergy has played an important role in new discoveries related to HIV pathogenesis, understanding immune responses and vaccine development. Recently, the medical record system and research database have become fully electronic, utilizing software completely designed and managed by CFAR investigators with expertise in informatics, statistics and computer technology. These advancements place CFAR investigators in a unique position to lead collaborative clinical database and outcomes-based national and international projects, and to contribute meaningfully to policy debates regarding health care access and cost-effectiveness. A variety of domestic research training services have been strengthened, while international research training efforts are best exemplified by Clinical Core support, in full collaboration with the International Core. These Clinical Core services are essential for the conduct of a vast array of HIV/AIDS research at DAB and around the world.
The DAB CFAR is completely dependant on the Clinical Core for providing a variety of samples from well characterized patients to investigators performing innovative translational research. In fact, the majority of published work (78%) derived from Clinical Core services were synthesized from local and international independent investigators. Our Clinical Research Training services ensures that a continuous stream of young, local and international investigators become proficient in this area enabling an ever increasing group of individuals who will further the field of HIV translational research throughout the world.
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|Elion, Richard A; Althoff, Keri N; Zhang, Jinbing et al. (2018) Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV. J Acquir Immune Defic Syndr 78:62-72|
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|Stoll, Matthew L; Weiss, Pamela F; Weiss, Jennifer E et al. (2018) Age and fecal microbial strain-specific differences in patients with spondyloarthritis. Arthritis Res Ther 20:14|
|Subramaniam, Akila; Van Der Pol, William J; Ptacek, Travis et al. (2018) Midtrimester microbial DNA variations in maternal serum of women who experience spontaneous preterm birth. J Matern Fetal Neonatal Med :1-9|
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|Xu, Wanli; Luo, Zhenwu; Alekseyenko, Alexander V et al. (2018) Distinct systemic microbiome and microbial translocation are associated with plasma level of anti-CD4 autoantibody in HIV infection. Sci Rep 8:12863|
|Smith, Samuel R; Schaaf, Kaitlyn; Rajabalee, Nusrah et al. (2018) The phosphatase PPM1A controls monocyte-to-macrophage differentiation. Sci Rep 8:902|
|Wang, Yong; Schafer, Cara C; Hough, Kenneth P et al. (2018) Myeloid-Derived Suppressor Cells Impair B Cell Responses in Lung Cancer through IL-7 and STAT5. J Immunol 201:278-295|
|Jones, Robert B; Dorsett, Kaitlyn A; Hjelmeland, Anita B et al. (2018) The ST6Gal-I sialyltransferase protects tumor cells against hypoxia by enhancing HIF-1? signaling. J Biol Chem 293:5659-5667|
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