The overall goal of the Gene and Cellular Therapy Core (CoreG) is to provide support for HIV/AIDS-related research requiring stem cells, gene delivery vectors and technical expertise for efficient genetic modification of stem cells. Recent advancements in gene delivery vector systems and stem cell technologies have enabled genetic modification of human hematopoietic stem/progenitor cells (HSPC) to resist HIV infection. The Gene and Cellular Therapy Core is established to meet the increasing demand to promote and facilitate basic and translational research in this area by providing UCLA CFAR investigators and their domestic and international collaborators with highly purified and well characterized human CD34+ HSPC, embryonic stem cells (hESC), induced pluripotent stem cells (iPSC), human fetal tissues and lentiviral vector technologies that enable efficient genetic engineering of stem cells to resist HIV infection. The Core also provides consultation for researchers with limited experience in stem cell and viral vector technologies, in particular early stage investigators. As the use of stem cells and vector technology requires specialized expertise and resources for efficient genetic engineering of different types of stem cells, offering access to these technologies can significantly facilitate and expand the scope of UCLA CFAR research activities. Our services are more cost-effective than utilizing the limited commercial sources. Further value is added by customized technical support available from accessible and knowledgeable core staffs who can work closely with investigators to troubleshoot and optimize experiments, assist with institutional regulatory compliance documents and who are actively engaged in development and application of stem cell and vector technologies. These core services will facilitate translation of stem cell and gene therapy-related HIV research into therapeutic applications.

Public Health Relevance

The UCLA CFAR Gene and Cellular Therapy Core provides support for human stem cell-base3d gene therapy research. The core services and technical expertise can facilitate research efforts to make rapid progress towards providing a new therapy for HIV infected individuals to stably control HIV infection.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Center Core Grants (P30)
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Special Emphasis Panel (ZAI1-UKS-A (J1))
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University of California Los Angeles
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Das, Aritra; Li, Jianjun; Zhong, Fei et al. (2015) Factors associated with HIV and syphilis co-infection among men who have sex with men in seven Chinese cities. Int J STD AIDS 26:145-55
Shin, Sanghyuk S; Modongo, Chawangwa; Ncube, Ronald et al. (2015) Advanced immune suppression is associated with increased prevalence of mixed-strain Mycobacterium tuberculosis infections among persons at high risk for drug-resistant tuberculosis in Botswana. J Infect Dis 211:347-51
Lee, Sung-Jae; Li, Li; Lin, Chunqing et al. (2015) Challenges facing HIV-positive persons who use drugs and their families in Vietnam. AIDS Care 27:283-7
Holloway, Ian W; Padilla, Mark B; Willner, Lauren et al. (2015) Effects of minority stress processes on the mental health of Latino men who have sex with men and women: a qualitative study. Arch Sex Behav 44:2087-97
Epeldegui, Marta; Blom, Bianca; Uittenbogaart, Christel H (2015) BST2/Tetherin is constitutively expressed on human thymocytes with the phenotype and function of Treg cells. Eur J Immunol 45:728-37
le Roux, Ingrid M; Rotheram-Borus, Mary Jane; Stein, Judith et al. (2014) The impact of paraprofessional home visitors on infants' growth and health at 18 months. Vulnerable Child Youth Stud 9:291-304
Martin, N T; Nakamura, K; Paila, U et al. (2014) Homozygous mutation of MTPAP causes cellular radiosensitivity and persistent DNA double-strand breaks. Cell Death Dis 5:e1130
Preza, Gloria C; Tanner, Karen; Elliott, Julie et al. (2014) Antigen-presenting cell candidates for HIV-1 transmission in human distal colonic mucosa defined by CD207 dendritic cells and CD209 macrophages. AIDS Res Hum Retroviruses 30:241-9
Remenyi, Roland; Qi, Hangfei; Su, Sheng-Yao et al. (2014) A comprehensive functional map of the hepatitis C virus genome provides a resource for probing viral proteins. MBio 5:e01469-14
Sullivan, Sheena G; Wu, Zunyou; Cao, Xiaobin et al. (2014) Continued drug use during methadone treatment in China: a retrospective analysis of 19,026 service users. J Subst Abuse Treat 47:86-92

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