CORE L: Clinical Research Facilitation Core. The UCLA CFAR Clinical Research Facilitation Core (Core L) provides support for investigators and their staff who are engaged in research involving human subjects with an overall goal to reduce the time between project funding and the initiation and completion of the research. The core has 2 specific aims: 1) To assist investigators with the regulatory approval aspects of biomedical, behavioral and basic translational patient-oriented research in HIV;2) To establish and maintain a continually-updated research participants'registry that will assist investigators with identifying and enrolling subjects into patient-oriented HIV research at UCLA. This core has created a streamlined process for IRB and other regulatory filing and established a v/ay to identify and contact potential research subjects, which reduces costs and the time needed to receive various institutional regulatory approvals and to identify potential subjects for their research. In addition new clinical and translational faculty as well as fellows and postdoctoral students receive training from this core in human subjects regulatory requirements, in proper IRB and other required submissions and how best to recruit for subjects from the diverse and often hard-to-reach populations of HIV-infected and at-risk individuals in the greater LA community. The core provides UCLA investigators, research trainees and staff access to resources that would otherwise not be available or which may be unaffordable to help expedite their research. The UCLA CFAR Clinical Research Facilitation Core also provides valuable recruitment and enrollment tools which help both existing and new faculty expedite their research and which serves as an attractive value added resource for the recruitment and retention of faculty working in HIV at UCLA. To accomplish these aims the Clinical Research Facilitation Core maintains a Regulatory Support arm, and within the last year, has designed and initiated the Research Study Volunteer Project (RSVP) arm, each of which provides services to UCLA CFAR investigators and trainees involved in HIV research who choose to avail themselves of these services. The RSVP program, initiated in late 2011, is in its subject recruitment and implementation phase. We intend to expand and make it more widely available with this competitive renewal.

Public Health Relevance

The CORE L Regulatory Support provides a centralized resource for assisting investigators in meeting the complex regulatory requirements for conducting patient-oriented research. The Research Study Volunteer Project (RSVP) serves as a resource for CFAR investigators to improve the efficiency of their research efforts by creating and maintaining a database of HIV-infected and uninfected individuals in the Los Angeles area who are interested and willing to be contacted for HIV-related research studies and/or are willing to have their self-reported medical information mined for research

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
2P30AI028697-24
Application #
8520709
Study Section
Special Emphasis Panel (ZAI1-UKS-A (J1))
Project Start
Project End
Budget Start
2013-03-05
Budget End
2014-02-28
Support Year
24
Fiscal Year
2013
Total Cost
$338,999
Indirect Cost
$68,572
Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Qi, Hangfei; Chu, Virginia; Wu, Nicholas C et al. (2017) Systematic identification of anti-interferon function on hepatitis C virus genome reveals p7 as an immune evasion protein. Proc Natl Acad Sci U S A 114:2018-2023
Graham, Nicholas A; Minasyan, Aspram; Lomova, Anastasia et al. (2017) Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures. Mol Syst Biol 13:914
Castaneda, Julie T; Harui, Airi; Roth, Michael D (2017) Regulation of Cell Surface CB2 Receptor during Human B Cell Activation and Differentiation. J Neuroimmune Pharmacol 12:544-554
Harawa, Nina T; Holloway, Ian W; Leibowitz, Arleen et al. (2017) Serious concerns regarding a meta-analysis of preexposure prophylaxis use and STI acquisition. AIDS 31:739-740
Richardson-Harman, Nicola; Parody, Robert; Anton, Peter et al. (2017) Analytical Advances in the Ex Vivo Challenge Efficacy Assay. AIDS Res Hum Retroviruses 33:395-403
Foo, Suan-Sin; Chen, Weiqiang; Chan, Yen et al. (2017) Asian Zika virus strains target CD14+ blood monocytes and induce M2-skewed immunosuppression during pregnancy. Nat Microbiol 2:1558-1570
Bergstrom, K; Fu, J; Johansson, M E V et al. (2017) Core 1- and 3-derived O-glycans collectively maintain the colonic mucus barrier and protect against spontaneous colitis in mice. Mucosal Immunol 10:91-103
Farmer, Shu; Mindry, Deborah; Comulada, W Scott et al. (2017) Mobile Phone Ecological Momentary Assessment of Daily Stressors Among People Living With HIV: Elucidating Factors Underlying Health-Related Challenges in Daily Routines. J Assoc Nurses AIDS Care 28:737-751
Tan, Diane; Holloway, Ian W; Gildner, Jennifer et al. (2017) Alcohol Use and HIV Risk Within Social Networks of MSM Sex Workers in the Dominican Republic. AIDS Behav 21:216-227
Bristow, Claire C; Lee, Sung-Jae; Severe, Linda et al. (2017) Attributes of diagnostic tests to increase uptake of dual testing for syphilis and HIV in Port-au-Prince, Haiti. Int J STD AIDS 28:259-264

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