CORE L: Clinical Research Facilitation Core. The UCLA CFAR Clinical Research Facilitation Core (Core L) provides support for investigators and their staff who are engaged in research involving human subjects with an overall goal to reduce the time between project funding and the initiation and completion of the research. The core has 2 specific aims: 1) To assist investigators with the regulatory approval aspects of biomedical, behavioral and basic translational patient-oriented research in HIV;2) To establish and maintain a continually-updated research participants'registry that will assist investigators with identifying and enrolling subjects into patient-oriented HIV research at UCLA. This core has created a streamlined process for IRB and other regulatory filing and established a v/ay to identify and contact potential research subjects, which reduces costs and the time needed to receive various institutional regulatory approvals and to identify potential subjects for their research. In addition new clinical and translational faculty as well as fellows and postdoctoral students receive training from this core in human subjects regulatory requirements, in proper IRB and other required submissions and how best to recruit for subjects from the diverse and often hard-to-reach populations of HIV-infected and at-risk individuals in the greater LA community. The core provides UCLA investigators, research trainees and staff access to resources that would otherwise not be available or which may be unaffordable to help expedite their research. The UCLA CFAR Clinical Research Facilitation Core also provides valuable recruitment and enrollment tools which help both existing and new faculty expedite their research and which serves as an attractive value added resource for the recruitment and retention of faculty working in HIV at UCLA. To accomplish these aims the Clinical Research Facilitation Core maintains a Regulatory Support arm, and within the last year, has designed and initiated the Research Study Volunteer Project (RSVP) arm, each of which provides services to UCLA CFAR investigators and trainees involved in HIV research who choose to avail themselves of these services. The RSVP program, initiated in late 2011, is in its subject recruitment and implementation phase. We intend to expand and make it more widely available with this competitive renewal.

Public Health Relevance

The CORE L Regulatory Support provides a centralized resource for assisting investigators in meeting the complex regulatory requirements for conducting patient-oriented research. The Research Study Volunteer Project (RSVP) serves as a resource for CFAR investigators to improve the efficiency of their research efforts by creating and maintaining a database of HIV-infected and uninfected individuals in the Los Angeles area who are interested and willing to be contacted for HIV-related research studies and/or are willing to have their self-reported medical information mined for research

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
2P30AI028697-24
Application #
8520709
Study Section
Special Emphasis Panel (ZAI1-UKS-A (J1))
Project Start
Project End
Budget Start
2013-03-05
Budget End
2014-02-28
Support Year
24
Fiscal Year
2013
Total Cost
$338,999
Indirect Cost
$68,572
Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Lake, Jordan E; Popov, Mikhail; Post, Wendy S et al. (2016) Visceral fat is associated with brain structure independent of human immunodeficiency virus infection status. J Neurovirol :
Lowe, Emily; Truscott, Laurel C; De Oliveira, Satiro N (2016) In Vitro Generation of Human NK Cells Expressing Chimeric Antigen Receptor Through Differentiation of Gene-Modified Hematopoietic Stem Cells. Methods Mol Biol 1441:241-51
Epeldegui, Marta; Lee, Jeannette Y; Martínez, Anna C et al. (2016) Predictive Value of Cytokines and Immune Activation Biomarkers in AIDS-Related Non-Hodgkin Lymphoma Treated with Rituximab plus Infusional EPOCH (AMC-034 trial). Clin Cancer Res 22:328-36
Tsai, Alexander C; Tomlinson, Mark; Comulada, W Scott et al. (2016) Intimate Partner Violence and Depression Symptom Severity among South African Women during Pregnancy and Postpartum: Population-Based Prospective Cohort Study. PLoS Med 13:e1001943
Peckham-Gregory, Erin C; Thapa, Dharma R; Martinson, Jeremy et al. (2016) MicroRNA-related polymorphisms and non-Hodgkin lymphoma susceptibility in the Multicenter AIDS Cohort Study. Cancer Epidemiol 45:47-57
Tsai, Alexander C; Tomlinson, Mark; Comulada, W Scott et al. (2016) Food insufficiency, depression, and the modifying role of social support: Evidence from a population-based, prospective cohort of pregnant women in peri-urban South Africa. Soc Sci Med 151:69-77
Liu, Sandy; Cadaneanu, Radu M; Zhang, Baohui et al. (2016) Keratin 13 Is Enriched in Prostate Tubule-Initiating Cells and May Identify Primary Prostate Tumors that Metastasize to the Bone. PLoS One 11:e0163232
Shimizu, Saki; Yadav, Swati Seth; An, Dong Sung (2016) Stable Delivery of CCR5-Directed shRNA into Human Primary Peripheral Blood Mononuclear Cells and Hematopoietic Stem/Progenitor Cells via a Lentiviral Vector. Methods Mol Biol 1364:235-48
Deng, Yun; Zhao, Jian; Sakurai, Daisuke et al. (2016) Decreased SMG7 expression associates with lupus-risk variants and elevated antinuclear antibody production. Ann Rheum Dis 75:2007-2013
Dou, Diana R; Calvanese, Vincenzo; Sierra, Maria I et al. (2016) Medial HOXA genes demarcate haematopoietic stem cell fate during human development. Nat Cell Biol 18:595-606

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