The purpose of the International Research Core is to promote and facilitate translational HIV/AIDS research by Baylor-UTHouston CFAR members in international settings. Over the past 10 years, the Baylor International Pediatric AIDS Initiative (BIPAI), supported in part by the International Research Core, has grown from a small, laboratory-based program focused in Romania to encompass the world's largest network of pediatric and family HIV treatment and research centers with over 30,000 HIV-infected patients in care. These centers are linked with one another, and together they serve as a resource capable of facilitating collaborative HIV/AIDS research across nine distinct international settings in Romania, Botswana, Lesotho, Malawi, Swaziland, Uganda, Tanzania, Burkina Faso, and Kenya. The International Research Core has been extraordinarily efficient and productive to date. The partnership with the Stefan Nicolau Institute of Virology in Bucharest has been a particular source of pride;our support for this relationship is reflected in our request for continued allocation of a substantial proportion of CFAR International Research Core funds to this partner. The CFAR International Research Core has contributed greatly to the success of the NIH-funded AIDS International Research and Training Program scholars. Other projects (such as the BANA 2 trial in Gaborone, Botswana) have been catalyzed by CFAR input and contributions. The CFAR International Research Core is now poised for exponential growth, as nearly limitless opportunities for epidemiological, operational, and clinical research can be realized through the newly implemented electronic medical records system. This electronic medical records system currently includes data on 30,000 patients in seven sites. This new tool has the potential to galvanize both retrospective and prospective research among existing core users and will attract additional new users to the core.

Public Health Relevance

The Center for AIDS Research (CFAR) at Baylor-UTHouston supports research on the pathogenesis, prevention, detection, and treatment of HIV infection and AIDS. The CFAR has been an essential catalyst for HIV/AIDS research in the Houston area. The State of Texas ranks fourth in the total number of AIDS cases in the United States. The International Research Core provides infrastructure and capacity for international research at a network of sites in Africa and Romania.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI036211-18
Application #
8382346
Study Section
Special Emphasis Panel (ZAI1-JBS-A)
Project Start
Project End
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
18
Fiscal Year
2012
Total Cost
$195,938
Indirect Cost
$54,004
Name
Baylor College of Medicine
Department
Type
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Chaboub, Lesley S; Manalo, Jeanne M; Lee, Hyun Kyoung et al. (2016) Temporal Profiling of Astrocyte Precursors Reveals Parallel Roles for Asef during Development and after Injury. J Neurosci 36:11904-11917
Bui, Thanh Cong; Tran, Ly Thi-Hai; Hor, Leng Bun et al. (2016) Intravaginal Practices in Female Sex Workers in Cambodia: A Qualitative Study. Arch Sex Behav 45:935-43
Shore, Amy N; Chang, Chi-Hsuan; Kwon, Oh-Joon et al. (2016) PTEN is required to maintain luminal epithelial homeostasis and integrity in the adult mammary gland. Dev Biol 409:202-17
Pethő, Zoltán; Tanner, Mark R; Tajhya, Rajeev B et al. (2016) Different expression of β subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes. Arthritis Res Ther 18:103
Kwon, Oh-Joon; Zhang, Li; Xin, Li (2016) Stem Cell Antigen-1 Identifies a Distinct Androgen-Independent Murine Prostatic Luminal Cell Lineage with Bipotent Potential. Stem Cells 34:191-202
Gundry, Michael C; Brunetti, Lorenzo; Lin, Angelique et al. (2016) Highly Efficient Genome Editing of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9. Cell Rep 17:1453-1461
Yang, Liubin; Rodriguez, Benjamin; Mayle, Allison et al. (2016) DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias. Cancer Cell 29:922-34
Arya, Monisha; Patel, Sajani; Kumar, Disha et al. (2016) Why Physicians Don't Ask: Interpersonal and Intrapersonal Barriers to HIV Testing-Making a Case for a Patient-Initiated Campaign. J Int Assoc Provid AIDS Care 15:306-12
Toneff, M J; Sreekumar, A; Tinnirello, A et al. (2016) The Z-cad dual fluorescent sensor detects dynamic changes between the epithelial and mesenchymal cellular states. BMC Biol 14:47
Feng, Zizhen; Yao, Yuan; Zhou, Chao et al. (2016) Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia. J Hematol Oncol 9:24

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