Core G - The Clinical Investigation and Biostatistics (CB) Core supports and enables studies of the pathogenesis, treatment, and prevention of HIV disease and its complications. The Core functions as a central access point for basic, clinical, and translational investigators by providing expertise in clinical study design, study implementation, patient recruitment, clinical evaluations for research, and specimen and data collection. Importantly, the Core provides biostatistical consultation for study design, grant preparation, power considerations and statistical analysis of study results as well as assistance with manuscript preparation. The CFAR web portal allows users to submit requests to the CB Core in a uniform, easy-to-use, and readily available format that ensures rapid response to requested services. A key innovation of the CB Core is the availability of prospectively collected, high quality, real-time clinical data, from the 3000 patients in current clinical care at the Owen Clinic, which is linked to a specimen repository and patient-based outcome measures (i.e., quality of life, adherence). The data and specimens allow for identification of and access to subjects and specimens that meet specific criteria for interventional, epidemiologic, behavioral, or basic science projects. The Core interacts with other CFAR cores to enable research requiring laboratory and clinical expertise, fosters multidisciplinary research among basic, clinical, and behavioral scientists, and teaches and mentors junior investigators in the principles of clinical investigation. CFAR funding permits the CB Core to offer its services to new and junior investigators without charge in most cases. Quality-assured data sets, with key data elements that have been reviewed for consistent definitions and accuracy, are provided free to the CFAR academic community. The resources from the CB Core have been further expanded and leveraged by collaboration with seven additional CFARs across the country to form the CFAR Network of Integrated Clinical Systems (CNICS).
The specific aims of the CB Core are: to support clinical investigation and translational research;to encourage, mentor and train the next generation of HIV clinical investigators;and to provide education about and access to HIV-related research opportunities and CFAR research findings to all HIV-infected individuals, including women and underrepresented minorities in the CFAR community.

Public Health Relevance

The Clinical Investigation and Biostatistics (CB) Core promotes and enables research aimed at important questions concerning the pathogenesis, treatment, and prevention of HIV disease and its complications. The Core functions as a central access point for basic, clinical and translational investigators by providing key resources including expertise in study design and implementation, statistical analysis, patient recruitment, research clinical evaluation and specimen and data collection.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI036214-20
Application #
8648959
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
20
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Mills, Jon C; Harman, Jeffrey S; Cook, Robert L et al. (2017) Comparative effectiveness of dual vs. single-action antidepressants on HIV clinical outcomes in HIV-infected people with depression. AIDS 31:2515-2524
Hoenigl, Martin; Braun, Dominique L; Kouyos, Roger et al. (2017) Evaluation of the Predictive Potential of the Short Acute Retroviral Syndrome Severity Score for HIV-1 Disease Progression in Individuals With Acute HIV Infection. J Acquir Immune Defic Syndr 74:e114-e117
Morris, Sheldon R; Zhao, Mitchell; Smith, Davey M et al. (2017) Longitudinal Viral Dynamics in Semen During Early HIV Infection. Clin Infect Dis 64:428-434
Wagner, Gabriel A; Landais, Elise; Caballero, Gemma et al. (2017) Intrasubtype B HIV-1 Superinfection Correlates with Delayed Neutralizing Antibody Response. J Virol 91:
Monroe, Anne K; Fleishman, John A; Voss, Cindy C et al. (2017) Assessing Antiretroviral Use During Gaps in HIV Primary Care Using Multisite Medicaid Claims and Clinical Data. J Acquir Immune Defic Syndr 76:82-89
Chaillon, Antoine; Nakazawa, Masato; Wertheim, Joel O et al. (2017) No Substantial Evidence for Sexual Transmission of Minority HIV Drug Resistance Mutations in Men Who Have Sex with Men. J Virol 91:
Hartzler, Bryan; Carlini, Beatriz H; Newville, Howard et al. (2017) Identifying HIV care enrollees at-risk for cannabis use disorder. AIDS Care 29:846-850
Akrami, Kevan; Coletta, Joelle; Mehta, Sanjay et al. (2017) Gordonia sternal wound infection treated with ceftaroline: case report and literature review. JMM Case Rep 4:e005113
Gianella, Sara; Taylor, Jeff; Brown, Timothy R et al. (2017) Can research at the end of life be a useful tool to advance HIV cure? AIDS 31:1-4
Spies, Georgina; Fennema-Notestine, Christine; Cherner, Mariana et al. (2017) Changes in cognitive function in women with HIV infection and early life stress. AIDS Care 29:14-23

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