Core H - The Protein Expression and Proteomics Core comprises two distinct, but highly interactive components at The Scripps Research Institute. Dr. John Elder, co-director, oversees the protein expression and purification component of the Core. Dr. Bruce Torbett, co-director, oversees the proteomics section, which provides state-of-the-art mass spectrometry, as well as other protein analytical methodology and instrumentation. The protein expression component facilitates the expression and purification of proteins required by the various CFAR-associated research programs. Moreover, the Core maintains in stock commonly used viral proteins, thus providing resources that may not otherwise be available to the community. The proteomic component of the Core provides state-of-the-art mass spectrometry instrumentation and bioinformatics, electrophoretic technologies, and additional bioanalytical instrumentation to analyze viral and cellular proteins important to ongoing studies by the members of the CFAR program. The Core also provides protein expression and proteomic advice, training, and consultation to the CFAR community. Access to such advice, reagents, methodologies, and technologies provides the CFAR community with unique resources not commonly found in research laboratories or cores.
The Protein Expression and Proteomics Core provides to CFAR-associated research programs services for the expression and purification of viral and cellular proteins as well as proteomic analyses of proteins from viruses and infected tissues and cells. The availability of advice, training, consultation, reagents, methodologies, and technologies offered by the Core is commonly beyond the reach of many research groups and, as such, is highly significant to the overall success ofthe CFAR research program.
|Chin, Bum Sik; Chaillon, Antoine; Mehta, Sanjay R et al. (2016) Molecular epidemiology identifies HIV transmission networks associated with younger age and heterosexual exposure among Korean individuals. J Med Virol 88:1832-5|
|Choi, Jun Yong; Chaillon, Antoine; Oh, Jin Ok et al. (2016) HIV migration between blood plasma and cellular subsets before and after HIV therapy. J Med Virol 88:606-13|
|Gianella, Sara; Kosakovsky Pond, Sergei L; Oliveira, Michelli F et al. (2016) Compartmentalized HIV rebound in the central nervous system after interruption of antiretroviral therapy. Virus Evol 2:vew020|
|Seifert, Marva; Georghiou, Sophia B; Catanzaro, Donald et al. (2016) MTBDRplus and MTBDRsl Assays: Absence of Wild-Type Probe Hybridization and Implications for Detection of Drug-Resistant Tuberculosis. J Clin Microbiol 54:912-8|
|Karris, Maile Y; Umlauf, Anya; Vaida, Florin et al. (2016) A randomized controlled clinical trial on the impact of CCR5 blockade with maraviroc in early infection on T-cell dynamics. Medicine (Baltimore) 95:e5315|
|Hoenigl, Martin; Chaillon, Antoine; Moore, David J et al. (2016) Clear Links Between Starting Methamphetamine and Increasing Sexual Risk Behavior: A Cohort Study Among Men Who Have Sex With Men. J Acquir Immune Defic Syndr 71:551-7|
|CÃ¡ceres, Carlos F; Borquez, Annick; Klausner, Jeffrey D et al. (2016) Implementation of pre-exposure prophylaxis for human immunodeficiency virus infection: progress and emerging issues in research and policy. J Int AIDS Soc 19:21108|
|Smith, Laramie R; Patterson, Thomas L; Magis-Rodriguez, Carlos et al. (2016) Engagement in the HIV Care Continuum among Key Populations in Tijuana, Mexico. AIDS Behav 20:1017-25|
|Freeman, Michael L; Lederman, Michael M; Gianella, Sara (2016) Partners in Crime: The Role of CMV in Immune Dysregulation and Clinical Outcome During HIV Infection. Curr HIV/AIDS Rep 13:10-9|
|Toth, Mate; Flandreau, Elizabeth I; Deslauriers, Jessica et al. (2016) Overexpression of Forebrain CRH During Early Life Increases Trauma Susceptibility in Adulthood. Neuropsychopharmacology 41:1681-90|
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